| Full name: deoxyribonuclease 1 like 2 | Alias Symbol: DNAS1L2 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 1775 | HGNC ID: HGNC:2958 | Ensembl Gene: ENSG00000167968 | OMIM ID: 602622 |
| Drug and gene relationship at DGIdb | |||
Expression of DNASE1L2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNASE1L2 | 1775 | 207192_at | -0.0316 | 0.9307 | |
| GSE20347 | DNASE1L2 | 1775 | 207192_at | 0.0449 | 0.6069 | |
| GSE23400 | DNASE1L2 | 1775 | 207192_at | 0.0182 | 0.6385 | |
| GSE26886 | DNASE1L2 | 1775 | 207192_at | 0.5427 | 0.0022 | |
| GSE29001 | DNASE1L2 | 1775 | 207192_at | -0.0743 | 0.6487 | |
| GSE38129 | DNASE1L2 | 1775 | 207192_at | -0.0494 | 0.6193 | |
| GSE45670 | DNASE1L2 | 1775 | 207192_at | 0.0289 | 0.8250 | |
| GSE53622 | DNASE1L2 | 1775 | 75791 | 0.0696 | 0.5930 | |
| GSE53624 | DNASE1L2 | 1775 | 75791 | 0.0924 | 0.4004 | |
| GSE63941 | DNASE1L2 | 1775 | 207192_at | 0.1234 | 0.5956 | |
| GSE77861 | DNASE1L2 | 1775 | 207192_at | 0.0502 | 0.6935 | |
| SRP219564 | DNASE1L2 | 1775 | RNAseq | -0.3368 | 0.5072 | |
| TCGA | DNASE1L2 | 1775 | RNAseq | 0.4091 | 0.3458 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DNASE1L2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNASE1L2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNASE1L2 | 1775 | 5 | 5 | 20 | |
| GSE20123 | DNASE1L2 | 1775 | 5 | 4 | 21 | |
| GSE43470 | DNASE1L2 | 1775 | 4 | 7 | 32 | |
| GSE46452 | DNASE1L2 | 1775 | 38 | 1 | 20 | |
| GSE47630 | DNASE1L2 | 1775 | 13 | 6 | 21 | |
| GSE54993 | DNASE1L2 | 1775 | 3 | 5 | 62 | |
| GSE54994 | DNASE1L2 | 1775 | 5 | 9 | 39 | |
| GSE60625 | DNASE1L2 | 1775 | 4 | 0 | 7 | |
| GSE74703 | DNASE1L2 | 1775 | 4 | 5 | 27 | |
| GSE74704 | DNASE1L2 | 1775 | 3 | 2 | 15 | |
| TCGA | DNASE1L2 | 1775 | 19 | 14 | 63 |
Total number of gains: 103; Total number of losses: 58; Total Number of normals: 327.
Somatic mutations of DNASE1L2:
Generating mutation plots.
Highly correlated genes for DNASE1L2:
Showing top 20/481 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNASE1L2 | POU3F1 | 0.710141 | 3 | 0 | 3 |
| DNASE1L2 | GPR162 | 0.710011 | 4 | 0 | 4 |
| DNASE1L2 | CNGB3 | 0.706788 | 3 | 0 | 3 |
| DNASE1L2 | SAMD4B | 0.705559 | 3 | 0 | 3 |
| DNASE1L2 | NSMF | 0.698372 | 3 | 0 | 3 |
| DNASE1L2 | CNR1 | 0.691399 | 3 | 0 | 3 |
| DNASE1L2 | MEIS3 | 0.688155 | 3 | 0 | 3 |
| DNASE1L2 | MRM1 | 0.682638 | 3 | 0 | 3 |
| DNASE1L2 | GRASP | 0.682256 | 3 | 0 | 3 |
| DNASE1L2 | LINC01348 | 0.676977 | 3 | 0 | 3 |
| DNASE1L2 | TSPYL2 | 0.675782 | 4 | 0 | 3 |
| DNASE1L2 | MC2R | 0.674402 | 4 | 0 | 4 |
| DNASE1L2 | LUZP4 | 0.672463 | 4 | 0 | 4 |
| DNASE1L2 | KCNS1 | 0.672159 | 5 | 0 | 4 |
| DNASE1L2 | FFAR1 | 0.668398 | 3 | 0 | 3 |
| DNASE1L2 | HMX1 | 0.667489 | 5 | 0 | 5 |
| DNASE1L2 | C19orf44 | 0.66615 | 3 | 0 | 3 |
| DNASE1L2 | CCL25 | 0.66517 | 3 | 0 | 3 |
| DNASE1L2 | SNAPC2 | 0.664953 | 5 | 0 | 4 |
| DNASE1L2 | SIGLEC8 | 0.663439 | 5 | 0 | 4 |
For details and further investigation, click here
