| Full name: 6-phosphogluconolactonase | Alias Symbol: 6PGL | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 25796 | HGNC ID: HGNC:8903 | Ensembl Gene: ENSG00000130313 | OMIM ID: 604951 |
| Drug and gene relationship at DGIdb | |||
Expression of PGLS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PGLS | 25796 | 218388_at | -0.2406 | 0.7053 | |
| GSE20347 | PGLS | 25796 | 218388_at | -0.8368 | 0.0000 | |
| GSE23400 | PGLS | 25796 | 218388_at | -0.1642 | 0.0803 | |
| GSE26886 | PGLS | 25796 | 218387_s_at | 0.6730 | 0.0010 | |
| GSE29001 | PGLS | 25796 | 218387_s_at | -0.7056 | 0.0389 | |
| GSE38129 | PGLS | 25796 | 218388_at | -0.3478 | 0.0200 | |
| GSE45670 | PGLS | 25796 | 218388_at | -0.0823 | 0.6065 | |
| GSE63941 | PGLS | 25796 | 218388_at | 0.2982 | 0.4264 | |
| GSE77861 | PGLS | 25796 | 218388_at | -0.3601 | 0.1914 | |
| GSE97050 | PGLS | 25796 | A_33_P3357918 | -0.2283 | 0.5378 | |
| SRP007169 | PGLS | 25796 | RNAseq | -1.5997 | 0.0000 | |
| SRP008496 | PGLS | 25796 | RNAseq | -1.4589 | 0.0000 | |
| SRP064894 | PGLS | 25796 | RNAseq | 0.4255 | 0.2954 | |
| SRP133303 | PGLS | 25796 | RNAseq | -0.3845 | 0.0005 | |
| SRP159526 | PGLS | 25796 | RNAseq | -0.5459 | 0.0117 | |
| SRP193095 | PGLS | 25796 | RNAseq | -0.5837 | 0.0000 | |
| SRP219564 | PGLS | 25796 | RNAseq | 0.2365 | 0.5452 | |
| TCGA | PGLS | 25796 | RNAseq | 0.1347 | 0.0344 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PGLS expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PGLS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PGLS | 25796 | 4 | 4 | 22 | |
| GSE20123 | PGLS | 25796 | 3 | 2 | 25 | |
| GSE43470 | PGLS | 25796 | 2 | 6 | 35 | |
| GSE46452 | PGLS | 25796 | 47 | 1 | 11 | |
| GSE47630 | PGLS | 25796 | 4 | 8 | 28 | |
| GSE54993 | PGLS | 25796 | 15 | 4 | 51 | |
| GSE54994 | PGLS | 25796 | 6 | 14 | 33 | |
| GSE60625 | PGLS | 25796 | 9 | 0 | 2 | |
| GSE74703 | PGLS | 25796 | 2 | 4 | 30 | |
| GSE74704 | PGLS | 25796 | 0 | 2 | 18 | |
| TCGA | PGLS | 25796 | 17 | 9 | 70 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of PGLS:
Generating mutation plots.
Highly correlated genes for PGLS:
Showing top 20/350 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PGLS | ZNF700 | 0.787971 | 3 | 0 | 3 |
| PGLS | TMEM129 | 0.756407 | 3 | 0 | 3 |
| PGLS | SLC25A29 | 0.748614 | 3 | 0 | 3 |
| PGLS | PTDSS2 | 0.746074 | 3 | 0 | 3 |
| PGLS | ADCK1 | 0.738479 | 3 | 0 | 3 |
| PGLS | SIN3A | 0.732934 | 3 | 0 | 3 |
| PGLS | DUSP23 | 0.715531 | 3 | 0 | 3 |
| PGLS | CTBS | 0.712879 | 3 | 0 | 3 |
| PGLS | ACAD9 | 0.712333 | 3 | 0 | 3 |
| PGLS | MRPS31 | 0.709958 | 3 | 0 | 3 |
| PGLS | MSRB2 | 0.708333 | 3 | 0 | 3 |
| PGLS | ZNF513 | 0.707156 | 3 | 0 | 3 |
| PGLS | ARL4A | 0.706917 | 3 | 0 | 3 |
| PGLS | PROSER1 | 0.705031 | 3 | 0 | 3 |
| PGLS | LSM10 | 0.703723 | 3 | 0 | 3 |
| PGLS | KIAA0319L | 0.702571 | 3 | 0 | 3 |
| PGLS | AURKAIP1 | 0.701848 | 4 | 0 | 3 |
| PGLS | TSNARE1 | 0.701161 | 3 | 0 | 3 |
| PGLS | NUDT19 | 0.696404 | 3 | 0 | 3 |
| PGLS | ZNF837 | 0.694534 | 3 | 0 | 3 |
For details and further investigation, click here
