| Full name: SIN3 transcription regulator family member A | Alias Symbol: KIAA0700|DKFZP434K2235 | ||
| Type: protein-coding gene | Cytoband: 15q24.2 | ||
| Entrez ID: 25942 | HGNC ID: HGNC:19353 | Ensembl Gene: ENSG00000169375 | OMIM ID: 607776 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SIN3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIN3A | 25942 | 238005_s_at | -0.2908 | 0.6068 | |
| GSE26886 | SIN3A | 25942 | 238005_s_at | 1.0812 | 0.0001 | |
| GSE45670 | SIN3A | 25942 | 238005_s_at | -0.8755 | 0.0000 | |
| GSE53622 | SIN3A | 25942 | 67653 | 0.3171 | 0.0000 | |
| GSE53624 | SIN3A | 25942 | 67653 | 0.3532 | 0.0000 | |
| GSE63941 | SIN3A | 25942 | 225135_at | 1.0431 | 0.0066 | |
| GSE77861 | SIN3A | 25942 | 238006_at | -0.0752 | 0.6478 | |
| GSE97050 | SIN3A | 25942 | A_23_P367676 | -0.5569 | 0.0906 | |
| SRP007169 | SIN3A | 25942 | RNAseq | 0.9762 | 0.0060 | |
| SRP008496 | SIN3A | 25942 | RNAseq | 0.6193 | 0.0061 | |
| SRP064894 | SIN3A | 25942 | RNAseq | -0.0356 | 0.8341 | |
| SRP133303 | SIN3A | 25942 | RNAseq | 0.1017 | 0.5611 | |
| SRP159526 | SIN3A | 25942 | RNAseq | 0.2719 | 0.1545 | |
| SRP193095 | SIN3A | 25942 | RNAseq | 0.2980 | 0.0008 | |
| SRP219564 | SIN3A | 25942 | RNAseq | -0.0573 | 0.7909 | |
| TCGA | SIN3A | 25942 | RNAseq | 0.0595 | 0.1747 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SIN3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIN3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIN3A | 25942 | 8 | 1 | 21 | |
| GSE20123 | SIN3A | 25942 | 8 | 1 | 21 | |
| GSE43470 | SIN3A | 25942 | 4 | 6 | 33 | |
| GSE46452 | SIN3A | 25942 | 3 | 7 | 49 | |
| GSE47630 | SIN3A | 25942 | 8 | 10 | 22 | |
| GSE54993 | SIN3A | 25942 | 5 | 6 | 59 | |
| GSE54994 | SIN3A | 25942 | 5 | 6 | 42 | |
| GSE60625 | SIN3A | 25942 | 4 | 0 | 7 | |
| GSE74703 | SIN3A | 25942 | 4 | 3 | 29 | |
| GSE74704 | SIN3A | 25942 | 4 | 1 | 15 | |
| TCGA | SIN3A | 25942 | 15 | 15 | 66 |
Total number of gains: 68; Total number of losses: 56; Total Number of normals: 364.
Somatic mutations of SIN3A:
Generating mutation plots.
Highly correlated genes for SIN3A:
Showing top 20/235 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIN3A | INPP5B | 0.786059 | 3 | 0 | 3 |
| SIN3A | LRRC40 | 0.784225 | 3 | 0 | 3 |
| SIN3A | MRPS31 | 0.783125 | 3 | 0 | 3 |
| SIN3A | PLCG1 | 0.776438 | 3 | 0 | 3 |
| SIN3A | CDKN1C | 0.773201 | 3 | 0 | 3 |
| SIN3A | SGCA | 0.770264 | 3 | 0 | 3 |
| SIN3A | DMPK | 0.755622 | 3 | 0 | 3 |
| SIN3A | SH2B1 | 0.749366 | 3 | 0 | 3 |
| SIN3A | EIF3L | 0.74687 | 3 | 0 | 3 |
| SIN3A | DOCK5 | 0.745537 | 3 | 0 | 3 |
| SIN3A | APOLD1 | 0.745012 | 3 | 0 | 3 |
| SIN3A | SIK1 | 0.73969 | 3 | 0 | 3 |
| SIN3A | ITGA8 | 0.73372 | 5 | 0 | 5 |
| SIN3A | PGLS | 0.732934 | 3 | 0 | 3 |
| SIN3A | ZNF570 | 0.730016 | 3 | 0 | 3 |
| SIN3A | FAHD1 | 0.729173 | 3 | 0 | 3 |
| SIN3A | A4GALT | 0.722857 | 3 | 0 | 3 |
| SIN3A | BNIP2 | 0.711849 | 4 | 0 | 4 |
| SIN3A | SMU1 | 0.710822 | 3 | 0 | 3 |
| SIN3A | ERCC2 | 0.7105 | 3 | 0 | 3 |
For details and further investigation, click here
