| Full name: ADP ribosylation factor like GTPase 4A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7p21.3 | ||
| Entrez ID: 10124 | HGNC ID: HGNC:695 | Ensembl Gene: ENSG00000122644 | OMIM ID: 604786 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ARL4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARL4A | 10124 | 205020_s_at | -1.0525 | 0.0900 | |
| GSE20347 | ARL4A | 10124 | 205020_s_at | -0.5955 | 0.0005 | |
| GSE23400 | ARL4A | 10124 | 205020_s_at | -0.1681 | 0.1392 | |
| GSE26886 | ARL4A | 10124 | 205020_s_at | -0.2264 | 0.4885 | |
| GSE29001 | ARL4A | 10124 | 205020_s_at | -0.6586 | 0.0551 | |
| GSE38129 | ARL4A | 10124 | 205020_s_at | -0.2861 | 0.1180 | |
| GSE45670 | ARL4A | 10124 | 205020_s_at | -0.6745 | 0.0021 | |
| GSE53622 | ARL4A | 10124 | 94629 | -0.9284 | 0.0000 | |
| GSE53624 | ARL4A | 10124 | 94629 | -0.6966 | 0.0000 | |
| GSE63941 | ARL4A | 10124 | 205020_s_at | 0.8087 | 0.0524 | |
| GSE77861 | ARL4A | 10124 | 205020_s_at | -0.4186 | 0.3444 | |
| GSE97050 | ARL4A | 10124 | A_23_P145761 | -0.5345 | 0.2332 | |
| SRP007169 | ARL4A | 10124 | RNAseq | -1.9974 | 0.0002 | |
| SRP008496 | ARL4A | 10124 | RNAseq | -1.3116 | 0.0006 | |
| SRP064894 | ARL4A | 10124 | RNAseq | -0.9333 | 0.0000 | |
| SRP133303 | ARL4A | 10124 | RNAseq | -0.5085 | 0.0481 | |
| SRP159526 | ARL4A | 10124 | RNAseq | -0.6072 | 0.0244 | |
| SRP193095 | ARL4A | 10124 | RNAseq | -1.1762 | 0.0000 | |
| SRP219564 | ARL4A | 10124 | RNAseq | -0.5060 | 0.3403 | |
| TCGA | ARL4A | 10124 | RNAseq | -0.0283 | 0.7558 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ARL4A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARL4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARL4A | 10124 | 14 | 2 | 14 | |
| GSE20123 | ARL4A | 10124 | 14 | 2 | 14 | |
| GSE43470 | ARL4A | 10124 | 5 | 0 | 38 | |
| GSE46452 | ARL4A | 10124 | 11 | 1 | 47 | |
| GSE47630 | ARL4A | 10124 | 9 | 1 | 30 | |
| GSE54993 | ARL4A | 10124 | 0 | 6 | 64 | |
| GSE54994 | ARL4A | 10124 | 22 | 1 | 30 | |
| GSE60625 | ARL4A | 10124 | 0 | 0 | 11 | |
| GSE74703 | ARL4A | 10124 | 5 | 0 | 31 | |
| GSE74704 | ARL4A | 10124 | 8 | 2 | 10 | |
| TCGA | ARL4A | 10124 | 54 | 7 | 35 |
Total number of gains: 142; Total number of losses: 22; Total Number of normals: 324.
Somatic mutations of ARL4A:
Generating mutation plots.
Highly correlated genes for ARL4A:
Showing top 20/760 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARL4A | YAP1 | 0.747801 | 4 | 0 | 3 |
| ARL4A | USP8 | 0.739209 | 4 | 0 | 4 |
| ARL4A | NAA20 | 0.727901 | 3 | 0 | 3 |
| ARL4A | COMMD10 | 0.727819 | 3 | 0 | 3 |
| ARL4A | TIFA | 0.72461 | 3 | 0 | 3 |
| ARL4A | DIP2B | 0.722192 | 3 | 0 | 3 |
| ARL4A | WDR13 | 0.720038 | 3 | 0 | 3 |
| ARL4A | TMEM132C | 0.713934 | 3 | 0 | 3 |
| ARL4A | BDP1 | 0.712557 | 3 | 0 | 3 |
| ARL4A | CD59 | 0.709658 | 3 | 0 | 3 |
| ARL4A | PGLS | 0.706917 | 3 | 0 | 3 |
| ARL4A | ZNF564 | 0.70489 | 3 | 0 | 3 |
| ARL4A | CA13 | 0.693581 | 3 | 0 | 3 |
| ARL4A | C11orf54 | 0.689637 | 4 | 0 | 3 |
| ARL4A | C15orf41 | 0.686061 | 4 | 0 | 4 |
| ARL4A | RBM20 | 0.681894 | 3 | 0 | 3 |
| ARL4A | CSTA | 0.68102 | 4 | 0 | 4 |
| ARL4A | IQGAP1 | 0.680998 | 4 | 0 | 3 |
| ARL4A | PINK1 | 0.680777 | 5 | 0 | 4 |
| ARL4A | RHOT1 | 0.676873 | 4 | 0 | 3 |
For details and further investigation, click here
