| Full name: methionine sulfoxide reductase B2 | Alias Symbol: PILB|CGI-131|CBS1|CBS-1 | ||
| Type: protein-coding gene | Cytoband: 10p12.2 | ||
| Entrez ID: 22921 | HGNC ID: HGNC:17061 | Ensembl Gene: ENSG00000148450 | OMIM ID: 613782 |
| Drug and gene relationship at DGIdb | |||
Expression of MSRB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MSRB2 | 22921 | 218773_s_at | -0.3680 | 0.4361 | |
| GSE20347 | MSRB2 | 22921 | 218773_s_at | -0.7268 | 0.0007 | |
| GSE23400 | MSRB2 | 22921 | 218773_s_at | -0.4349 | 0.0008 | |
| GSE26886 | MSRB2 | 22921 | 218773_s_at | -0.0148 | 0.9725 | |
| GSE29001 | MSRB2 | 22921 | 218773_s_at | -0.5807 | 0.0885 | |
| GSE38129 | MSRB2 | 22921 | 218773_s_at | -0.7012 | 0.0047 | |
| GSE45670 | MSRB2 | 22921 | 218773_s_at | -0.5117 | 0.0049 | |
| GSE53622 | MSRB2 | 22921 | 10231 | -0.5815 | 0.0000 | |
| GSE53624 | MSRB2 | 22921 | 10231 | -0.4606 | 0.0000 | |
| GSE63941 | MSRB2 | 22921 | 218773_s_at | -1.1162 | 0.0131 | |
| GSE77861 | MSRB2 | 22921 | 218773_s_at | -0.6921 | 0.0195 | |
| GSE97050 | MSRB2 | 22921 | A_23_P97932 | -0.5794 | 0.1204 | |
| SRP007169 | MSRB2 | 22921 | RNAseq | -1.0276 | 0.0558 | |
| SRP008496 | MSRB2 | 22921 | RNAseq | -0.7577 | 0.0141 | |
| SRP064894 | MSRB2 | 22921 | RNAseq | -0.3983 | 0.2406 | |
| SRP133303 | MSRB2 | 22921 | RNAseq | -0.3806 | 0.0497 | |
| SRP159526 | MSRB2 | 22921 | RNAseq | -0.7858 | 0.0007 | |
| SRP193095 | MSRB2 | 22921 | RNAseq | -0.3326 | 0.0029 | |
| SRP219564 | MSRB2 | 22921 | RNAseq | -0.7651 | 0.2400 | |
| TCGA | MSRB2 | 22921 | RNAseq | -0.1533 | 0.0542 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MSRB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MSRB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MSRB2 | 22921 | 4 | 8 | 18 | |
| GSE20123 | MSRB2 | 22921 | 4 | 7 | 19 | |
| GSE43470 | MSRB2 | 22921 | 4 | 4 | 35 | |
| GSE46452 | MSRB2 | 22921 | 1 | 14 | 44 | |
| GSE47630 | MSRB2 | 22921 | 5 | 15 | 20 | |
| GSE54993 | MSRB2 | 22921 | 9 | 0 | 61 | |
| GSE54994 | MSRB2 | 22921 | 3 | 9 | 41 | |
| GSE60625 | MSRB2 | 22921 | 0 | 0 | 11 | |
| GSE74703 | MSRB2 | 22921 | 3 | 2 | 31 | |
| GSE74704 | MSRB2 | 22921 | 0 | 6 | 14 | |
| TCGA | MSRB2 | 22921 | 18 | 26 | 52 |
Total number of gains: 51; Total number of losses: 91; Total Number of normals: 346.
Somatic mutations of MSRB2:
Generating mutation plots.
Highly correlated genes for MSRB2:
Showing top 20/938 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MSRB2 | ICA1L | 0.764564 | 4 | 0 | 3 |
| MSRB2 | TCF7L1 | 0.764056 | 3 | 0 | 3 |
| MSRB2 | AKAP6 | 0.7475 | 3 | 0 | 3 |
| MSRB2 | AFAP1 | 0.724937 | 3 | 0 | 3 |
| MSRB2 | AKT3 | 0.722039 | 3 | 0 | 3 |
| MSRB2 | CWF19L2 | 0.713863 | 3 | 0 | 3 |
| MSRB2 | PGLS | 0.708333 | 3 | 0 | 3 |
| MSRB2 | TNFRSF19 | 0.70817 | 3 | 0 | 3 |
| MSRB2 | RRAS | 0.707946 | 6 | 0 | 5 |
| MSRB2 | AFF3 | 0.70616 | 4 | 0 | 4 |
| MSRB2 | HSD11B1 | 0.700435 | 3 | 0 | 3 |
| MSRB2 | SNX25 | 0.699383 | 3 | 0 | 3 |
| MSRB2 | ZNF334 | 0.695888 | 3 | 0 | 3 |
| MSRB2 | ICK | 0.695188 | 3 | 0 | 3 |
| MSRB2 | PRKAG2 | 0.69286 | 4 | 0 | 4 |
| MSRB2 | FYCO1 | 0.692289 | 9 | 0 | 9 |
| MSRB2 | TSPAN3 | 0.692059 | 3 | 0 | 3 |
| MSRB2 | LSM11 | 0.691444 | 5 | 0 | 5 |
| MSRB2 | CD34 | 0.690223 | 5 | 0 | 4 |
| MSRB2 | SNAPIN | 0.6892 | 3 | 0 | 3 |
For details and further investigation, click here
