| Full name: pleckstrin homology like domain family B member 3 | Alias Symbol: FLJ40193 | ||
| Type: protein-coding gene | Cytoband: 19q13.31 | ||
| Entrez ID: 653583 | HGNC ID: HGNC:30499 | Ensembl Gene: ENSG00000176531 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PHLDB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHLDB3 | 653583 | 1557948_at | -0.4504 | 0.5495 | |
| GSE26886 | PHLDB3 | 653583 | 1557948_at | -1.3432 | 0.0000 | |
| GSE45670 | PHLDB3 | 653583 | 1557948_at | -0.1374 | 0.6874 | |
| GSE53622 | PHLDB3 | 653583 | 4351 | -0.7665 | 0.0000 | |
| GSE53624 | PHLDB3 | 653583 | 4351 | -1.2109 | 0.0000 | |
| GSE63941 | PHLDB3 | 653583 | 1557948_at | 0.0590 | 0.9223 | |
| GSE77861 | PHLDB3 | 653583 | 1557948_at | -0.6171 | 0.1127 | |
| GSE97050 | PHLDB3 | 653583 | A_32_P184488 | -0.1327 | 0.6554 | |
| SRP007169 | PHLDB3 | 653583 | RNAseq | -2.1326 | 0.0000 | |
| SRP008496 | PHLDB3 | 653583 | RNAseq | -2.1075 | 0.0000 | |
| SRP064894 | PHLDB3 | 653583 | RNAseq | -1.5937 | 0.0000 | |
| SRP133303 | PHLDB3 | 653583 | RNAseq | -1.7442 | 0.0000 | |
| SRP159526 | PHLDB3 | 653583 | RNAseq | -1.4874 | 0.0002 | |
| SRP193095 | PHLDB3 | 653583 | RNAseq | -1.2923 | 0.0000 | |
| SRP219564 | PHLDB3 | 653583 | RNAseq | -1.8915 | 0.0057 | |
| TCGA | PHLDB3 | 653583 | RNAseq | 0.2080 | 0.0820 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by PHLDB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHLDB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHLDB3 | 653583 | 6 | 5 | 19 | |
| GSE20123 | PHLDB3 | 653583 | 5 | 4 | 21 | |
| GSE43470 | PHLDB3 | 653583 | 4 | 11 | 28 | |
| GSE46452 | PHLDB3 | 653583 | 45 | 1 | 13 | |
| GSE47630 | PHLDB3 | 653583 | 8 | 6 | 26 | |
| GSE54993 | PHLDB3 | 653583 | 17 | 4 | 49 | |
| GSE54994 | PHLDB3 | 653583 | 6 | 12 | 35 | |
| GSE60625 | PHLDB3 | 653583 | 9 | 0 | 2 | |
| GSE74703 | PHLDB3 | 653583 | 4 | 7 | 25 | |
| GSE74704 | PHLDB3 | 653583 | 4 | 2 | 14 | |
| TCGA | PHLDB3 | 653583 | 14 | 15 | 67 |
Total number of gains: 122; Total number of losses: 67; Total Number of normals: 299.
Somatic mutations of PHLDB3:
Generating mutation plots.
Highly correlated genes for PHLDB3:
Showing top 20/729 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHLDB3 | FAM163B | 0.83099 | 3 | 0 | 3 |
| PHLDB3 | RNF222 | 0.795496 | 3 | 0 | 3 |
| PHLDB3 | NOTO | 0.794687 | 3 | 0 | 3 |
| PHLDB3 | OTOP3 | 0.793669 | 3 | 0 | 3 |
| PHLDB3 | TEN1 | 0.786283 | 3 | 0 | 3 |
| PHLDB3 | KRTAP20-1 | 0.783042 | 3 | 0 | 3 |
| PHLDB3 | MUC22 | 0.780986 | 3 | 0 | 3 |
| PHLDB3 | NHLRC4 | 0.777082 | 4 | 0 | 4 |
| PHLDB3 | KPRP | 0.775028 | 3 | 0 | 3 |
| PHLDB3 | CLEC18C | 0.769508 | 3 | 0 | 3 |
| PHLDB3 | OR2Z1 | 0.766634 | 3 | 0 | 3 |
| PHLDB3 | SLC6A18 | 0.765182 | 3 | 0 | 3 |
| PHLDB3 | DCD | 0.756331 | 4 | 0 | 3 |
| PHLDB3 | BARHL2 | 0.753756 | 3 | 0 | 3 |
| PHLDB3 | ATP2B3 | 0.752624 | 3 | 0 | 3 |
| PHLDB3 | CD164L2 | 0.751993 | 3 | 0 | 3 |
| PHLDB3 | VSIG10L | 0.73923 | 7 | 0 | 7 |
| PHLDB3 | NCCRP1 | 0.738285 | 4 | 0 | 3 |
| PHLDB3 | CPNE6 | 0.736858 | 4 | 0 | 4 |
| PHLDB3 | OR10G8 | 0.735253 | 3 | 0 | 3 |
For details and further investigation, click here
