| Full name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta | Alias Symbol: C2-PI3K|PI3K-C2beta | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 5287 | HGNC ID: HGNC:8972 | Ensembl Gene: ENSG00000133056 | OMIM ID: 602838 |
| Drug and gene relationship at DGIdb | |||
Expression of PIK3C2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PIK3C2B | 5287 | 204484_at | -0.1329 | 0.8800 | |
| GSE20347 | PIK3C2B | 5287 | 204484_at | -0.6476 | 0.0001 | |
| GSE23400 | PIK3C2B | 5287 | 204484_at | -0.3801 | 0.0000 | |
| GSE26886 | PIK3C2B | 5287 | 204484_at | -0.7877 | 0.0006 | |
| GSE29001 | PIK3C2B | 5287 | 204484_at | -0.6955 | 0.0029 | |
| GSE38129 | PIK3C2B | 5287 | 204484_at | -0.5957 | 0.0001 | |
| GSE45670 | PIK3C2B | 5287 | 204484_at | -0.3976 | 0.0385 | |
| GSE53622 | PIK3C2B | 5287 | 52143 | 0.1023 | 0.1688 | |
| GSE53624 | PIK3C2B | 5287 | 52143 | -0.3559 | 0.0000 | |
| GSE63941 | PIK3C2B | 5287 | 204484_at | 1.6225 | 0.0111 | |
| GSE77861 | PIK3C2B | 5287 | 204484_at | -0.1664 | 0.2538 | |
| GSE97050 | PIK3C2B | 5287 | A_33_P3419419 | -0.0180 | 0.9410 | |
| SRP007169 | PIK3C2B | 5287 | RNAseq | -1.3340 | 0.0003 | |
| SRP008496 | PIK3C2B | 5287 | RNAseq | -1.4113 | 0.0000 | |
| SRP064894 | PIK3C2B | 5287 | RNAseq | -0.9003 | 0.0000 | |
| SRP133303 | PIK3C2B | 5287 | RNAseq | -0.9350 | 0.0000 | |
| SRP159526 | PIK3C2B | 5287 | RNAseq | -0.7333 | 0.0312 | |
| SRP193095 | PIK3C2B | 5287 | RNAseq | -0.7516 | 0.0003 | |
| SRP219564 | PIK3C2B | 5287 | RNAseq | -0.4893 | 0.2933 | |
| TCGA | PIK3C2B | 5287 | RNAseq | -0.3021 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by PIK3C2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PIK3C2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PIK3C2B | 5287 | 11 | 0 | 19 | |
| GSE20123 | PIK3C2B | 5287 | 11 | 0 | 19 | |
| GSE43470 | PIK3C2B | 5287 | 6 | 0 | 37 | |
| GSE46452 | PIK3C2B | 5287 | 3 | 1 | 55 | |
| GSE47630 | PIK3C2B | 5287 | 14 | 0 | 26 | |
| GSE54993 | PIK3C2B | 5287 | 0 | 6 | 64 | |
| GSE54994 | PIK3C2B | 5287 | 15 | 0 | 38 | |
| GSE60625 | PIK3C2B | 5287 | 0 | 0 | 11 | |
| GSE74703 | PIK3C2B | 5287 | 6 | 0 | 30 | |
| GSE74704 | PIK3C2B | 5287 | 5 | 0 | 15 | |
| TCGA | PIK3C2B | 5287 | 44 | 4 | 48 |
Total number of gains: 115; Total number of losses: 11; Total Number of normals: 362.
Somatic mutations of PIK3C2B:
Generating mutation plots.
Highly correlated genes for PIK3C2B:
Showing top 20/496 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PIK3C2B | KRTAP9-1 | 0.781226 | 3 | 0 | 3 |
| PIK3C2B | BEST3 | 0.741948 | 3 | 0 | 3 |
| PIK3C2B | POM121L12 | 0.73983 | 3 | 0 | 3 |
| PIK3C2B | TTC34 | 0.723093 | 3 | 0 | 3 |
| PIK3C2B | GLI4 | 0.710759 | 3 | 0 | 3 |
| PIK3C2B | VSIG10 | 0.706003 | 3 | 0 | 3 |
| PIK3C2B | GRIK4 | 0.68499 | 3 | 0 | 3 |
| PIK3C2B | RBAKDN | 0.67858 | 3 | 0 | 3 |
| PIK3C2B | LLGL2 | 0.678431 | 8 | 0 | 8 |
| PIK3C2B | SLC35A4 | 0.674318 | 3 | 0 | 3 |
| PIK3C2B | KRT80 | 0.670497 | 3 | 0 | 3 |
| PIK3C2B | CYP4F12 | 0.669792 | 8 | 0 | 8 |
| PIK3C2B | LHX9 | 0.658538 | 3 | 0 | 3 |
| PIK3C2B | CLRN2 | 0.656806 | 3 | 0 | 3 |
| PIK3C2B | S100A16 | 0.647139 | 4 | 0 | 4 |
| PIK3C2B | IQCF2 | 0.642495 | 3 | 0 | 3 |
| PIK3C2B | PADI1 | 0.641359 | 8 | 0 | 8 |
| PIK3C2B | CNDP2 | 0.637884 | 4 | 0 | 4 |
| PIK3C2B | PGLYRP2 | 0.637317 | 3 | 0 | 3 |
| PIK3C2B | DUOXA1 | 0.633693 | 4 | 0 | 3 |
For details and further investigation, click here
