| Full name: peptidyl arginine deiminase 1 | Alias Symbol: HPAD10|PDI1|PDI|PAD1 | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 29943 | HGNC ID: HGNC:18367 | Ensembl Gene: ENSG00000142623 | OMIM ID: 607934 |
| Drug and gene relationship at DGIdb | |||
Expression of PADI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PADI1 | 29943 | 223739_at | -3.8265 | 0.0409 | |
| GSE20347 | PADI1 | 29943 | 220962_s_at | -0.7419 | 0.0000 | |
| GSE23400 | PADI1 | 29943 | 220962_s_at | -1.4014 | 0.0000 | |
| GSE26886 | PADI1 | 29943 | 223739_at | -5.0611 | 0.0000 | |
| GSE29001 | PADI1 | 29943 | 220962_s_at | -0.9771 | 0.0001 | |
| GSE38129 | PADI1 | 29943 | 220962_s_at | -0.7905 | 0.0000 | |
| GSE45670 | PADI1 | 29943 | 223739_at | -1.9520 | 0.0153 | |
| GSE63941 | PADI1 | 29943 | 220962_s_at | 0.5793 | 0.0003 | |
| GSE77861 | PADI1 | 29943 | 220962_s_at | -0.5508 | 0.0023 | |
| SRP007169 | PADI1 | 29943 | RNAseq | -7.3327 | 0.0000 | |
| SRP008496 | PADI1 | 29943 | RNAseq | -7.2489 | 0.0000 | |
| SRP064894 | PADI1 | 29943 | RNAseq | -5.8361 | 0.0000 | |
| SRP133303 | PADI1 | 29943 | RNAseq | -6.0733 | 0.0000 | |
| SRP159526 | PADI1 | 29943 | RNAseq | -5.8965 | 0.0000 | |
| SRP219564 | PADI1 | 29943 | RNAseq | -5.4034 | 0.0000 | |
| TCGA | PADI1 | 29943 | RNAseq | 0.1685 | 0.7600 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by PADI1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PADI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PADI1 | 29943 | 0 | 5 | 25 | |
| GSE20123 | PADI1 | 29943 | 0 | 4 | 26 | |
| GSE43470 | PADI1 | 29943 | 0 | 8 | 35 | |
| GSE46452 | PADI1 | 29943 | 5 | 1 | 53 | |
| GSE47630 | PADI1 | 29943 | 8 | 3 | 29 | |
| GSE54993 | PADI1 | 29943 | 3 | 1 | 66 | |
| GSE54994 | PADI1 | 29943 | 10 | 4 | 39 | |
| GSE60625 | PADI1 | 29943 | 0 | 0 | 11 | |
| GSE74703 | PADI1 | 29943 | 0 | 5 | 31 | |
| GSE74704 | PADI1 | 29943 | 0 | 0 | 20 | |
| TCGA | PADI1 | 29943 | 9 | 22 | 65 |
Total number of gains: 35; Total number of losses: 53; Total Number of normals: 400.
Somatic mutations of PADI1:
Generating mutation plots.
Highly correlated genes for PADI1:
Showing top 20/1441 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PADI1 | ATG9B | 0.90079 | 4 | 0 | 4 |
| PADI1 | FAM3D | 0.900093 | 4 | 0 | 4 |
| PADI1 | SFTA2 | 0.896614 | 4 | 0 | 4 |
| PADI1 | CYSRT1 | 0.891893 | 4 | 0 | 4 |
| PADI1 | GDPD3 | 0.889816 | 8 | 0 | 8 |
| PADI1 | FCHO2 | 0.881564 | 4 | 0 | 4 |
| PADI1 | ULK3 | 0.881536 | 4 | 0 | 4 |
| PADI1 | EPS8L2 | 0.877568 | 8 | 0 | 8 |
| PADI1 | FUT6 | 0.875598 | 9 | 0 | 9 |
| PADI1 | CRISP3 | 0.872449 | 8 | 0 | 8 |
| PADI1 | UPK1A | 0.872117 | 8 | 0 | 8 |
| PADI1 | GYS2 | 0.868356 | 8 | 0 | 8 |
| PADI1 | EPS8L1 | 0.867589 | 9 | 0 | 9 |
| PADI1 | IL36A | 0.866259 | 8 | 0 | 8 |
| PADI1 | SPINK7 | 0.866087 | 4 | 0 | 4 |
| PADI1 | CLIC3 | 0.865809 | 8 | 0 | 8 |
| PADI1 | BNIPL | 0.863646 | 4 | 0 | 4 |
| PADI1 | FUT3 | 0.862136 | 8 | 0 | 8 |
| PADI1 | MXD1 | 0.861352 | 8 | 0 | 8 |
| PADI1 | VSIG10L | 0.860452 | 4 | 0 | 4 |
For details and further investigation, click here
