| Full name: tRNA methyltransferase 6 | Alias Symbol: GCD10|MGC5029|Gcd10p|CGI-09 | ||
| Type: protein-coding gene | Cytoband: 20p12.3 | ||
| Entrez ID: 51605 | HGNC ID: HGNC:20900 | Ensembl Gene: ENSG00000089195 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TRMT6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRMT6 | 51605 | 233970_s_at | 0.9415 | 0.0970 | |
| GSE26886 | TRMT6 | 51605 | 222768_s_at | 1.4214 | 0.0000 | |
| GSE45670 | TRMT6 | 51605 | 233970_s_at | 0.7039 | 0.0023 | |
| GSE53622 | TRMT6 | 51605 | 36221 | 0.6884 | 0.0000 | |
| GSE53624 | TRMT6 | 51605 | 36221 | 0.8636 | 0.0000 | |
| GSE63941 | TRMT6 | 51605 | 222768_s_at | 0.5221 | 0.2339 | |
| GSE77861 | TRMT6 | 51605 | 233970_s_at | 1.0994 | 0.0019 | |
| GSE97050 | TRMT6 | 51605 | A_23_P210747 | 0.6713 | 0.2151 | |
| SRP007169 | TRMT6 | 51605 | RNAseq | 0.0936 | 0.8281 | |
| SRP008496 | TRMT6 | 51605 | RNAseq | 0.6962 | 0.0311 | |
| SRP064894 | TRMT6 | 51605 | RNAseq | 0.6591 | 0.0043 | |
| SRP133303 | TRMT6 | 51605 | RNAseq | 0.8492 | 0.0000 | |
| SRP159526 | TRMT6 | 51605 | RNAseq | 0.8900 | 0.0241 | |
| SRP193095 | TRMT6 | 51605 | RNAseq | 0.5388 | 0.0000 | |
| SRP219564 | TRMT6 | 51605 | RNAseq | 1.0159 | 0.0219 | |
| TCGA | TRMT6 | 51605 | RNAseq | 0.3493 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by TRMT6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRMT6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRMT6 | 51605 | 11 | 2 | 17 | |
| GSE20123 | TRMT6 | 51605 | 11 | 2 | 17 | |
| GSE43470 | TRMT6 | 51605 | 12 | 1 | 30 | |
| GSE46452 | TRMT6 | 51605 | 26 | 1 | 32 | |
| GSE47630 | TRMT6 | 51605 | 18 | 4 | 18 | |
| GSE54993 | TRMT6 | 51605 | 1 | 14 | 55 | |
| GSE54994 | TRMT6 | 51605 | 25 | 2 | 26 | |
| GSE60625 | TRMT6 | 51605 | 0 | 0 | 11 | |
| GSE74703 | TRMT6 | 51605 | 9 | 1 | 26 | |
| GSE74704 | TRMT6 | 51605 | 5 | 1 | 14 | |
| TCGA | TRMT6 | 51605 | 40 | 11 | 45 |
Total number of gains: 158; Total number of losses: 39; Total Number of normals: 291.
Somatic mutations of TRMT6:
Generating mutation plots.
Highly correlated genes for TRMT6:
Showing top 20/1557 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRMT6 | MDM2 | 0.827312 | 3 | 0 | 3 |
| TRMT6 | NENF | 0.81873 | 3 | 0 | 3 |
| TRMT6 | UBA6 | 0.816699 | 3 | 0 | 3 |
| TRMT6 | CPT1A | 0.807164 | 3 | 0 | 3 |
| TRMT6 | ACACA | 0.796637 | 3 | 0 | 3 |
| TRMT6 | KIF2A | 0.793544 | 3 | 0 | 3 |
| TRMT6 | GINS1 | 0.792788 | 7 | 0 | 7 |
| TRMT6 | FEZ1 | 0.783577 | 3 | 0 | 3 |
| TRMT6 | PIK3R3 | 0.775001 | 3 | 0 | 3 |
| TRMT6 | CCT6A | 0.764024 | 4 | 0 | 3 |
| TRMT6 | TRADD | 0.7626 | 4 | 0 | 4 |
| TRMT6 | CTBP2 | 0.760795 | 3 | 0 | 3 |
| TRMT6 | PET117 | 0.760609 | 6 | 0 | 6 |
| TRMT6 | CIAO1 | 0.759148 | 4 | 0 | 4 |
| TRMT6 | CEP95 | 0.754194 | 3 | 0 | 3 |
| TRMT6 | SEL1L3 | 0.75321 | 3 | 0 | 3 |
| TRMT6 | TAF1C | 0.750624 | 3 | 0 | 3 |
| TRMT6 | SNRPB2 | 0.74979 | 8 | 0 | 8 |
| TRMT6 | SSRP1 | 0.743894 | 7 | 0 | 7 |
| TRMT6 | EME1 | 0.740563 | 5 | 0 | 5 |
For details and further investigation, click here
