| Full name: CXXC finger protein 1 | Alias Symbol: HsT2645|PCCX1|hCGBP|PHF18|CGBP|SPP1|CFP1|ZCGPC1 | ||
| Type: protein-coding gene | Cytoband: 18q21.1 | ||
| Entrez ID: 30827 | HGNC ID: HGNC:24343 | Ensembl Gene: ENSG00000154832 | OMIM ID: 609150 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CXXC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CXXC1 | 30827 | 48580_at | 0.2614 | 0.2584 | |
| GSE20347 | CXXC1 | 30827 | 48580_at | 0.1571 | 0.1765 | |
| GSE23400 | CXXC1 | 30827 | 48580_at | 0.0511 | 0.2095 | |
| GSE26886 | CXXC1 | 30827 | 48580_at | -0.0561 | 0.6394 | |
| GSE29001 | CXXC1 | 30827 | 48580_at | 0.0843 | 0.7563 | |
| GSE38129 | CXXC1 | 30827 | 48580_at | 0.0744 | 0.4451 | |
| GSE45670 | CXXC1 | 30827 | 48580_at | 0.2779 | 0.0068 | |
| GSE53622 | CXXC1 | 30827 | 169843 | -0.0853 | 0.2909 | |
| GSE53624 | CXXC1 | 30827 | 169843 | 0.0985 | 0.2169 | |
| GSE63941 | CXXC1 | 30827 | 48580_at | 0.4845 | 0.1271 | |
| GSE77861 | CXXC1 | 30827 | 48580_at | 0.4280 | 0.0192 | |
| GSE97050 | CXXC1 | 30827 | A_23_P141779 | 0.1529 | 0.5391 | |
| SRP007169 | CXXC1 | 30827 | RNAseq | -0.7015 | 0.0783 | |
| SRP008496 | CXXC1 | 30827 | RNAseq | -0.0300 | 0.9439 | |
| SRP064894 | CXXC1 | 30827 | RNAseq | 0.2804 | 0.1210 | |
| SRP133303 | CXXC1 | 30827 | RNAseq | -0.3053 | 0.0364 | |
| SRP159526 | CXXC1 | 30827 | RNAseq | 0.0805 | 0.7827 | |
| SRP193095 | CXXC1 | 30827 | RNAseq | 0.1370 | 0.3396 | |
| SRP219564 | CXXC1 | 30827 | RNAseq | -0.0561 | 0.8512 | |
| TCGA | CXXC1 | 30827 | RNAseq | -0.0860 | 0.1120 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CXXC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CXXC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CXXC1 | 30827 | 1 | 9 | 20 | |
| GSE20123 | CXXC1 | 30827 | 1 | 9 | 20 | |
| GSE43470 | CXXC1 | 30827 | 0 | 4 | 39 | |
| GSE46452 | CXXC1 | 30827 | 1 | 26 | 32 | |
| GSE47630 | CXXC1 | 30827 | 5 | 20 | 15 | |
| GSE54993 | CXXC1 | 30827 | 9 | 0 | 61 | |
| GSE54994 | CXXC1 | 30827 | 1 | 17 | 35 | |
| GSE60625 | CXXC1 | 30827 | 0 | 4 | 7 | |
| GSE74703 | CXXC1 | 30827 | 0 | 4 | 32 | |
| GSE74704 | CXXC1 | 30827 | 1 | 6 | 13 | |
| TCGA | CXXC1 | 30827 | 9 | 44 | 43 |
Total number of gains: 28; Total number of losses: 143; Total Number of normals: 317.
Somatic mutations of CXXC1:
Generating mutation plots.
Highly correlated genes for CXXC1:
Showing top 20/667 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CXXC1 | C18orf54 | 0.840182 | 3 | 0 | 3 |
| CXXC1 | DNAH14 | 0.803688 | 3 | 0 | 3 |
| CXXC1 | WDR81 | 0.800548 | 3 | 0 | 3 |
| CXXC1 | IQCE | 0.784347 | 3 | 0 | 3 |
| CXXC1 | PCYT1A | 0.783911 | 3 | 0 | 3 |
| CXXC1 | MRPS14 | 0.772255 | 3 | 0 | 3 |
| CXXC1 | PIK3R3 | 0.769121 | 3 | 0 | 3 |
| CXXC1 | SCARA3 | 0.766259 | 3 | 0 | 3 |
| CXXC1 | CLPTM1L | 0.762129 | 3 | 0 | 3 |
| CXXC1 | RIOK1 | 0.752675 | 3 | 0 | 3 |
| CXXC1 | C12orf45 | 0.747924 | 3 | 0 | 3 |
| CXXC1 | ZBED1 | 0.743748 | 3 | 0 | 3 |
| CXXC1 | SLC12A4 | 0.741609 | 3 | 0 | 3 |
| CXXC1 | CSNK1D | 0.740938 | 3 | 0 | 3 |
| CXXC1 | TP53I11 | 0.738589 | 4 | 0 | 4 |
| CXXC1 | INPP5E | 0.737898 | 4 | 0 | 4 |
| CXXC1 | IL18BP | 0.729481 | 4 | 0 | 4 |
| CXXC1 | CYHR1 | 0.725143 | 4 | 0 | 3 |
| CXXC1 | CCT5 | 0.724391 | 3 | 0 | 3 |
| CXXC1 | ABCF1 | 0.722519 | 3 | 0 | 3 |
For details and further investigation, click here
