| Full name: tubulin folding cofactor C | Alias Symbol: CFC | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 6903 | HGNC ID: HGNC:11580 | Ensembl Gene: ENSG00000124659 | OMIM ID: 602971 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TBCC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBCC | 6903 | 202495_at | 0.3693 | 0.3903 | |
| GSE20347 | TBCC | 6903 | 202495_at | -0.1117 | 0.3583 | |
| GSE23400 | TBCC | 6903 | 202495_at | 0.1455 | 0.0030 | |
| GSE26886 | TBCC | 6903 | 202495_at | 0.1254 | 0.4466 | |
| GSE29001 | TBCC | 6903 | 202495_at | -0.1697 | 0.2950 | |
| GSE38129 | TBCC | 6903 | 202495_at | 0.0399 | 0.7281 | |
| GSE45670 | TBCC | 6903 | 202495_at | 0.1672 | 0.0906 | |
| GSE53622 | TBCC | 6903 | 16322 | -0.1555 | 0.0641 | |
| GSE53624 | TBCC | 6903 | 16322 | -0.1033 | 0.2719 | |
| GSE63941 | TBCC | 6903 | 202495_at | -0.1961 | 0.5772 | |
| GSE77861 | TBCC | 6903 | 202495_at | 0.0466 | 0.8650 | |
| GSE97050 | TBCC | 6903 | A_24_P397584 | 0.0584 | 0.8369 | |
| SRP007169 | TBCC | 6903 | RNAseq | 0.3443 | 0.5621 | |
| SRP064894 | TBCC | 6903 | RNAseq | -0.1280 | 0.4815 | |
| SRP133303 | TBCC | 6903 | RNAseq | -0.0890 | 0.4726 | |
| SRP159526 | TBCC | 6903 | RNAseq | -0.1586 | 0.3782 | |
| SRP193095 | TBCC | 6903 | RNAseq | -0.1119 | 0.3134 | |
| SRP219564 | TBCC | 6903 | RNAseq | 0.3215 | 0.3840 | |
| TCGA | TBCC | 6903 | RNAseq | 0.0184 | 0.7715 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TBCC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBCC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBCC | 6903 | 7 | 0 | 23 | |
| GSE20123 | TBCC | 6903 | 7 | 0 | 23 | |
| GSE43470 | TBCC | 6903 | 6 | 0 | 37 | |
| GSE46452 | TBCC | 6903 | 2 | 9 | 48 | |
| GSE47630 | TBCC | 6903 | 8 | 4 | 28 | |
| GSE54993 | TBCC | 6903 | 3 | 2 | 65 | |
| GSE54994 | TBCC | 6903 | 11 | 4 | 38 | |
| GSE60625 | TBCC | 6903 | 0 | 1 | 10 | |
| GSE74703 | TBCC | 6903 | 6 | 0 | 30 | |
| GSE74704 | TBCC | 6903 | 3 | 0 | 17 | |
| TCGA | TBCC | 6903 | 20 | 13 | 63 |
Total number of gains: 73; Total number of losses: 33; Total Number of normals: 382.
Somatic mutations of TBCC:
Generating mutation plots.
Highly correlated genes for TBCC:
Showing top 20/363 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBCC | RPL7L1 | 0.804 | 3 | 0 | 3 |
| TBCC | SLC29A3 | 0.801973 | 3 | 0 | 3 |
| TBCC | MBOAT1 | 0.790243 | 3 | 0 | 3 |
| TBCC | SIDT2 | 0.788243 | 3 | 0 | 3 |
| TBCC | FAM53B | 0.785537 | 3 | 0 | 3 |
| TBCC | EEFSEC | 0.772371 | 3 | 0 | 3 |
| TBCC | PIK3R3 | 0.766658 | 3 | 0 | 3 |
| TBCC | BTN3A2 | 0.755121 | 3 | 0 | 3 |
| TBCC | MAU2 | 0.752247 | 3 | 0 | 3 |
| TBCC | NUB1 | 0.75164 | 3 | 0 | 3 |
| TBCC | HMGA1 | 0.749219 | 4 | 0 | 4 |
| TBCC | NAIF1 | 0.743687 | 3 | 0 | 3 |
| TBCC | GMCL1 | 0.734258 | 3 | 0 | 3 |
| TBCC | UHMK1 | 0.73161 | 3 | 0 | 3 |
| TBCC | RUNDC1 | 0.730855 | 3 | 0 | 3 |
| TBCC | MRPL44 | 0.725636 | 3 | 0 | 3 |
| TBCC | NR2F6 | 0.724939 | 4 | 0 | 4 |
| TBCC | HPS3 | 0.722242 | 3 | 0 | 3 |
| TBCC | ARMCX6 | 0.716616 | 3 | 0 | 3 |
| TBCC | ENPP5 | 0.715962 | 3 | 0 | 3 |
For details and further investigation, click here
