LEMD2

 

Full name: LEM domain containing 2 Alias Symbol: dJ482C21.1|NET25|LEM2
Type: protein-coding gene Cytoband: 6p21.31
Entrez ID: 221496 HGNC ID: HGNC:21244 Ensembl Gene: ENSG00000161904 OMIM ID: 616312
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 51/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of LEMD2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LEMD2 221496 224980_at 0.6486 0.1253
GSE26886 LEMD2 221496 224980_at 0.0570 0.7209
GSE45670 LEMD2 221496 224980_at 0.3966 0.0017
GSE53622 LEMD2 221496 56457 0.0807 0.2350
GSE53624 LEMD2 221496 56457 0.2275 0.0022
GSE63941 LEMD2 221496 224980_at 0.7888 0.0101
GSE77861 LEMD2 221496 224980_at 0.2165 0.3122
GSE97050 LEMD2 221496 A_24_P305960 0.1545 0.4324
SRP007169 LEMD2 221496 RNAseq -0.9320 0.0078
SRP008496 LEMD2 221496 RNAseq -0.7727 0.0003
SRP064894 LEMD2 221496 RNAseq 0.3298 0.0188
SRP133303 LEMD2 221496 RNAseq 0.1600 0.1909
SRP159526 LEMD2 221496 RNAseq 0.2355 0.3941
SRP193095 LEMD2 221496 RNAseq 0.1159 0.1539
SRP219564 LEMD2 221496 RNAseq 0.2283 0.3983
TCGA LEMD2 221496 RNAseq 0.0603 0.1999

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by LEMD2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LEMD2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LEMD2 221496 5 0 25
GSE20123 LEMD2 221496 5 0 25
GSE43470 LEMD2 221496 4 1 38
GSE46452 LEMD2 221496 2 9 48
GSE47630 LEMD2 221496 8 4 28
GSE54993 LEMD2 221496 3 1 66
GSE54994 LEMD2 221496 11 4 38
GSE60625 LEMD2 221496 1 0 10
GSE74703 LEMD2 221496 4 0 32
GSE74704 LEMD2 221496 2 0 18
TCGA LEMD2 221496 16 15 65

Total number of gains: 61; Total number of losses: 34; Total Number of normals: 393.  

 

Somatic mutations of LEMD2:

 

Generating mutation plots.

 

Highly correlated genes for LEMD2:

 

Showing top 20/709 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LEMD2KCTD150.838266303
LEMD2INTS10.82122303
LEMD2MLLT10.819356303
LEMD2CSNK2B0.813265404
LEMD2C12orf730.793614303
LEMD2CSTF2T0.788698303
LEMD2RNFT20.78763303
LEMD2PIK3R30.78425303
LEMD2GORAB0.783638303
LEMD2MAGOHB0.772083303
LEMD2UNG0.771438303
LEMD2PCNT0.768921303
LEMD2ZNF7660.768865303
LEMD2RNF1380.765499303
LEMD2HMGB10.764725303
LEMD2TDG0.76303
LEMD2SLC28A30.759388303
LEMD2MCMBP0.757793404
LEMD2TAPBP0.749982404
LEMD2XRCC10.748805303

For details and further investigation, click here