SHC3

 

Full name: SHC adaptor protein 3 Alias Symbol: N-Shc|NSHC|SHCC
Type: protein-coding gene Cytoband: 9q22.1
Entrez ID: 53358 HGNC ID: HGNC:18181 Ensembl Gene: ENSG00000148082 OMIM ID: 605263
Drug and gene relationship at DGIdb

 

SHC3 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04510Focal adhesion
hsa04650Natural killer cell mediated cytotoxicity
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa05214Glioma
hsa05220Chronic myeloid leukemia

 

Expression of SHC3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SHC3 53358 206330_s_at -0.1021 0.8268
GSE20347 SHC3 53358 206330_s_at -0.0976 0.2665
GSE23400 SHC3 53358 206330_s_at -0.1744 0.0000
GSE26886 SHC3 53358 243881_at 0.1307 0.1940
GSE29001 SHC3 53358 206330_s_at -0.1344 0.2949
GSE38129 SHC3 53358 206330_s_at -0.2147 0.0160
GSE45670 SHC3 53358 229824_at -0.4623 0.2058
GSE53622 SHC3 53358 41327 -0.3644 0.0000
GSE53624 SHC3 53358 41327 -0.2189 0.0492
GSE63941 SHC3 53358 229824_at -6.1066 0.0000
GSE77861 SHC3 53358 206330_s_at -0.0832 0.3889
GSE97050 SHC3 53358 A_33_P3216090 -0.1224 0.5607
SRP064894 SHC3 53358 RNAseq 0.3608 0.2756
SRP133303 SHC3 53358 RNAseq -1.0360 0.0052
SRP159526 SHC3 53358 RNAseq 0.0269 0.9600
SRP193095 SHC3 53358 RNAseq 1.4191 0.0000
SRP219564 SHC3 53358 RNAseq 0.2625 0.5579
TCGA SHC3 53358 RNAseq -0.2657 0.4323

Upregulated datasets: 1; Downregulated datasets: 2.  

 

Survival by SHC3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SHC3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SHC3 53358 5 10 15
GSE20123 SHC3 53358 5 10 15
GSE43470 SHC3 53358 6 3 34
GSE46452 SHC3 53358 6 14 39
GSE47630 SHC3 53358 1 18 21
GSE54993 SHC3 53358 4 2 64
GSE54994 SHC3 53358 6 11 36
GSE60625 SHC3 53358 0 0 11
GSE74703 SHC3 53358 5 3 28
GSE74704 SHC3 53358 3 7 10
TCGA SHC3 53358 21 24 51

Total number of gains: 62; Total number of losses: 102; Total Number of normals: 324.  

 

Somatic mutations of SHC3:

 

Generating mutation plots.

 

Highly correlated genes for SHC3:

 

Showing top 20/414 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SHC3GUCY2C0.750596303
SHC3CELF40.750074303
SHC3FBLN70.748498303
SHC3ENTPD10.747456403
SHC3SCN3A0.741496403
SHC3ATOH80.739358504
SHC3PKDCC0.733116303
SHC3VCAM10.720118303
SHC3ZNF5000.718439303
SHC3SIL10.708821303
SHC3TSKS0.707063404
SHC3MAGEL20.704128403
SHC3LRTM10.698247505
SHC3CLDN140.696406403
SHC3LRRN40.694623303
SHC3KATNAL20.693883303
SHC3PGC0.692967303
SHC3AK50.684972404
SHC3KRT850.681337303
SHC3TRO0.68124403

For details and further investigation, click here