| Full name: fibulin 1 | Alias Symbol: FBLN | ||
| Type: protein-coding gene | Cytoband: 22q13.31 | ||
| Entrez ID: 2192 | HGNC ID: HGNC:3600 | Ensembl Gene: ENSG00000077942 | OMIM ID: 135820 |
| Drug and gene relationship at DGIdb | |||
Expression of FBLN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBLN1 | 2192 | 202994_s_at | -1.3141 | 0.0873 | |
| GSE20347 | FBLN1 | 2192 | 202994_s_at | -0.1868 | 0.4666 | |
| GSE23400 | FBLN1 | 2192 | 202995_s_at | -0.6717 | 0.0013 | |
| GSE26886 | FBLN1 | 2192 | 201787_at | 0.9238 | 0.0264 | |
| GSE29001 | FBLN1 | 2192 | 201787_at | 0.0765 | 0.8704 | |
| GSE38129 | FBLN1 | 2192 | 202994_s_at | -0.7663 | 0.0485 | |
| GSE45670 | FBLN1 | 2192 | 202994_s_at | -2.7962 | 0.0000 | |
| GSE53622 | FBLN1 | 2192 | 56081 | -1.1157 | 0.0000 | |
| GSE53624 | FBLN1 | 2192 | 76033 | -0.9510 | 0.0000 | |
| GSE63941 | FBLN1 | 2192 | 202994_s_at | -2.7294 | 0.0068 | |
| GSE77861 | FBLN1 | 2192 | 201787_at | 0.4239 | 0.2594 | |
| GSE97050 | FBLN1 | 2192 | A_23_P433016 | -0.4187 | 0.3655 | |
| SRP007169 | FBLN1 | 2192 | RNAseq | 1.2145 | 0.0208 | |
| SRP008496 | FBLN1 | 2192 | RNAseq | 1.2598 | 0.0006 | |
| SRP064894 | FBLN1 | 2192 | RNAseq | -0.2493 | 0.5706 | |
| SRP133303 | FBLN1 | 2192 | RNAseq | -1.3268 | 0.0000 | |
| SRP159526 | FBLN1 | 2192 | RNAseq | -0.6217 | 0.0468 | |
| SRP193095 | FBLN1 | 2192 | RNAseq | 0.1144 | 0.3951 | |
| SRP219564 | FBLN1 | 2192 | RNAseq | 0.3542 | 0.6867 | |
| TCGA | FBLN1 | 2192 | RNAseq | -0.3578 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 4.
Survival by FBLN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBLN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBLN1 | 2192 | 5 | 6 | 19 | |
| GSE20123 | FBLN1 | 2192 | 4 | 5 | 21 | |
| GSE43470 | FBLN1 | 2192 | 2 | 6 | 35 | |
| GSE46452 | FBLN1 | 2192 | 31 | 2 | 26 | |
| GSE47630 | FBLN1 | 2192 | 9 | 4 | 27 | |
| GSE54993 | FBLN1 | 2192 | 3 | 6 | 61 | |
| GSE54994 | FBLN1 | 2192 | 11 | 7 | 35 | |
| GSE60625 | FBLN1 | 2192 | 5 | 0 | 6 | |
| GSE74703 | FBLN1 | 2192 | 2 | 4 | 30 | |
| GSE74704 | FBLN1 | 2192 | 2 | 3 | 15 | |
| TCGA | FBLN1 | 2192 | 27 | 15 | 54 |
Total number of gains: 101; Total number of losses: 58; Total Number of normals: 329.
Somatic mutations of FBLN1:
Generating mutation plots.
Highly correlated genes for FBLN1:
Showing top 20/1098 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBLN1 | CYP21A2 | 0.809114 | 3 | 0 | 3 |
| FBLN1 | CLEC3B | 0.806548 | 3 | 0 | 3 |
| FBLN1 | CCDC3 | 0.787175 | 5 | 0 | 5 |
| FBLN1 | RUNX1T1 | 0.782582 | 7 | 0 | 7 |
| FBLN1 | CHRDL1 | 0.776922 | 8 | 0 | 7 |
| FBLN1 | ZMYM3 | 0.773348 | 3 | 0 | 3 |
| FBLN1 | RHOU | 0.772608 | 5 | 0 | 5 |
| FBLN1 | JAM2 | 0.767218 | 10 | 0 | 10 |
| FBLN1 | AQP1 | 0.765003 | 8 | 0 | 8 |
| FBLN1 | GFRA1 | 0.76333 | 7 | 0 | 6 |
| FBLN1 | CADM3 | 0.762787 | 4 | 0 | 4 |
| FBLN1 | COL14A1 | 0.761533 | 9 | 0 | 8 |
| FBLN1 | OGN | 0.753225 | 10 | 0 | 9 |
| FBLN1 | ITPR1 | 0.752684 | 8 | 0 | 7 |
| FBLN1 | DIXDC1 | 0.751128 | 9 | 0 | 9 |
| FBLN1 | CXCL12 | 0.746547 | 10 | 0 | 9 |
| FBLN1 | MFAP4 | 0.745724 | 13 | 0 | 11 |
| FBLN1 | LINC01279 | 0.743492 | 4 | 0 | 4 |
| FBLN1 | ASPA | 0.742918 | 9 | 0 | 8 |
| FBLN1 | FGF7 | 0.740882 | 8 | 0 | 7 |
For details and further investigation, click here
