| Full name: notch receptor 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 4855 | HGNC ID: HGNC:7884 | Ensembl Gene: ENSG00000204301 | OMIM ID: 164951 |
| Drug and gene relationship at DGIdb | |||
NOTCH4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway | |
| hsa04919 | Thyroid hormone signaling pathway |
Expression of NOTCH4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NOTCH4 | 4855 | 205247_at | -0.1498 | 0.6556 | |
| GSE20347 | NOTCH4 | 4855 | 205247_at | -0.0757 | 0.3925 | |
| GSE23400 | NOTCH4 | 4855 | 205247_at | -0.1955 | 0.0000 | |
| GSE26886 | NOTCH4 | 4855 | 240786_at | 0.2950 | 0.0210 | |
| GSE29001 | NOTCH4 | 4855 | 205247_at | -0.2783 | 0.1212 | |
| GSE38129 | NOTCH4 | 4855 | 205247_at | -0.2490 | 0.0467 | |
| GSE45670 | NOTCH4 | 4855 | 205247_at | -0.1937 | 0.1452 | |
| GSE53622 | NOTCH4 | 4855 | 7878 | 0.0865 | 0.4587 | |
| GSE53624 | NOTCH4 | 4855 | 78809 | 0.1608 | 0.0646 | |
| GSE63941 | NOTCH4 | 4855 | 240786_at | 0.1384 | 0.3043 | |
| GSE77861 | NOTCH4 | 4855 | 240786_at | -0.0762 | 0.6259 | |
| GSE97050 | NOTCH4 | 4855 | A_23_P365614 | 0.2261 | 0.3379 | |
| SRP007169 | NOTCH4 | 4855 | RNAseq | 0.6913 | 0.1704 | |
| SRP064894 | NOTCH4 | 4855 | RNAseq | 0.6491 | 0.0105 | |
| SRP133303 | NOTCH4 | 4855 | RNAseq | 0.1439 | 0.6505 | |
| SRP159526 | NOTCH4 | 4855 | RNAseq | -0.3830 | 0.3485 | |
| SRP193095 | NOTCH4 | 4855 | RNAseq | 0.3317 | 0.0562 | |
| SRP219564 | NOTCH4 | 4855 | RNAseq | 0.0303 | 0.9448 | |
| TCGA | NOTCH4 | 4855 | RNAseq | -0.4105 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NOTCH4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NOTCH4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NOTCH4 | 4855 | 5 | 1 | 24 | |
| GSE20123 | NOTCH4 | 4855 | 5 | 1 | 24 | |
| GSE43470 | NOTCH4 | 4855 | 5 | 1 | 37 | |
| GSE46452 | NOTCH4 | 4855 | 1 | 10 | 48 | |
| GSE47630 | NOTCH4 | 4855 | 7 | 4 | 29 | |
| GSE54993 | NOTCH4 | 4855 | 2 | 1 | 67 | |
| GSE54994 | NOTCH4 | 4855 | 11 | 4 | 38 | |
| GSE60625 | NOTCH4 | 4855 | 0 | 1 | 10 | |
| GSE74703 | NOTCH4 | 4855 | 5 | 0 | 31 | |
| GSE74704 | NOTCH4 | 4855 | 2 | 0 | 18 | |
| TCGA | NOTCH4 | 4855 | 16 | 16 | 64 |
Total number of gains: 59; Total number of losses: 39; Total Number of normals: 390.
Somatic mutations of NOTCH4:
Generating mutation plots.
Highly correlated genes for NOTCH4:
Showing top 20/346 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NOTCH4 | GABRR2 | 0.788438 | 3 | 0 | 3 |
| NOTCH4 | TGFB2 | 0.752539 | 3 | 0 | 3 |
| NOTCH4 | TCF25 | 0.744269 | 3 | 0 | 3 |
| NOTCH4 | KLRG1 | 0.736778 | 4 | 0 | 3 |
| NOTCH4 | PKNOX2 | 0.71123 | 3 | 0 | 3 |
| NOTCH4 | BSN | 0.708073 | 3 | 0 | 3 |
| NOTCH4 | C6orf223 | 0.70533 | 3 | 0 | 3 |
| NOTCH4 | ZBTB10 | 0.703758 | 3 | 0 | 3 |
| NOTCH4 | EXOC3L1 | 0.695595 | 4 | 0 | 4 |
| NOTCH4 | CCDC150 | 0.69489 | 3 | 0 | 3 |
| NOTCH4 | PLD6 | 0.691172 | 3 | 0 | 3 |
| NOTCH4 | RNF31 | 0.689237 | 4 | 0 | 3 |
| NOTCH4 | GPR132 | 0.688494 | 4 | 0 | 4 |
| NOTCH4 | G0S2 | 0.68561 | 3 | 0 | 3 |
| NOTCH4 | TMEM255B | 0.679331 | 3 | 0 | 3 |
| NOTCH4 | PPP6R1 | 0.679263 | 3 | 0 | 3 |
| NOTCH4 | PNMT | 0.679031 | 3 | 0 | 3 |
| NOTCH4 | GPR183 | 0.678318 | 3 | 0 | 3 |
| NOTCH4 | ITGB3 | 0.676787 | 4 | 0 | 3 |
| NOTCH4 | CLDND2 | 0.674851 | 4 | 0 | 3 |
For details and further investigation, click here
