| Full name: gamma-aminobutyric acid type A receptor rho2 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q15 | ||
| Entrez ID: 2570 | HGNC ID: HGNC:4091 | Ensembl Gene: ENSG00000111886 | OMIM ID: 137162 |
| Drug and gene relationship at DGIdb | |||
GABRR2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa05032 | Morphine addiction |
Expression of GABRR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRR2 | 2570 | 208217_at | 0.0856 | 0.6508 | |
| GSE20347 | GABRR2 | 2570 | 208217_at | -0.0472 | 0.6708 | |
| GSE23400 | GABRR2 | 2570 | 208217_at | -0.1558 | 0.0000 | |
| GSE26886 | GABRR2 | 2570 | 208217_at | 0.2284 | 0.0626 | |
| GSE29001 | GABRR2 | 2570 | 208217_at | -0.1813 | 0.1670 | |
| GSE38129 | GABRR2 | 2570 | 208217_at | -0.1348 | 0.1665 | |
| GSE45670 | GABRR2 | 2570 | 208217_at | 0.0529 | 0.6114 | |
| GSE63941 | GABRR2 | 2570 | 208217_at | 0.1471 | 0.2484 | |
| GSE77861 | GABRR2 | 2570 | 208217_at | -0.0925 | 0.4624 | |
| GSE97050 | GABRR2 | 2570 | A_23_P93105 | -0.0103 | 0.9758 | |
| SRP064894 | GABRR2 | 2570 | RNAseq | 0.9048 | 0.0005 | |
| SRP133303 | GABRR2 | 2570 | RNAseq | 1.0795 | 0.0001 | |
| SRP159526 | GABRR2 | 2570 | RNAseq | 0.6588 | 0.1644 | |
| SRP193095 | GABRR2 | 2570 | RNAseq | 1.3721 | 0.0000 | |
| SRP219564 | GABRR2 | 2570 | RNAseq | 0.6216 | 0.1243 | |
| TCGA | GABRR2 | 2570 | RNAseq | 0.4579 | 0.2932 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by GABRR2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GABRR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRR2 | 2570 | 1 | 4 | 25 | |
| GSE20123 | GABRR2 | 2570 | 1 | 3 | 26 | |
| GSE43470 | GABRR2 | 2570 | 3 | 1 | 39 | |
| GSE46452 | GABRR2 | 2570 | 2 | 11 | 46 | |
| GSE47630 | GABRR2 | 2570 | 8 | 6 | 26 | |
| GSE54993 | GABRR2 | 2570 | 3 | 2 | 65 | |
| GSE54994 | GABRR2 | 2570 | 8 | 8 | 37 | |
| GSE60625 | GABRR2 | 2570 | 0 | 1 | 10 | |
| GSE74703 | GABRR2 | 2570 | 3 | 1 | 32 | |
| GSE74704 | GABRR2 | 2570 | 0 | 2 | 18 | |
| TCGA | GABRR2 | 2570 | 7 | 21 | 68 |
Total number of gains: 36; Total number of losses: 60; Total Number of normals: 392.
Somatic mutations of GABRR2:
Generating mutation plots.
Highly correlated genes for GABRR2:
Showing top 20/826 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRR2 | EPN1 | 0.794677 | 4 | 0 | 4 |
| GABRR2 | EDA2R | 0.792883 | 5 | 0 | 5 |
| GABRR2 | NOTCH4 | 0.788438 | 3 | 0 | 3 |
| GABRR2 | TNFRSF4 | 0.785435 | 3 | 0 | 3 |
| GABRR2 | E2F4 | 0.783026 | 5 | 0 | 5 |
| GABRR2 | ZNF358 | 0.767982 | 3 | 0 | 3 |
| GABRR2 | GRIN2D | 0.76505 | 4 | 0 | 4 |
| GABRR2 | FAM167B | 0.76282 | 3 | 0 | 3 |
| GABRR2 | GDF5 | 0.755928 | 5 | 0 | 5 |
| GABRR2 | PKNOX2 | 0.746218 | 5 | 0 | 5 |
| GABRR2 | G6PC2 | 0.741388 | 4 | 0 | 4 |
| GABRR2 | SYT13 | 0.741174 | 3 | 0 | 3 |
| GABRR2 | CISH | 0.73271 | 4 | 0 | 4 |
| GABRR2 | CAMK1G | 0.730352 | 4 | 0 | 4 |
| GABRR2 | C9orf16 | 0.728512 | 3 | 0 | 3 |
| GABRR2 | PAPPA2 | 0.727289 | 5 | 0 | 5 |
| GABRR2 | OTOR | 0.727236 | 5 | 0 | 5 |
| GABRR2 | NMNAT2 | 0.723759 | 4 | 0 | 4 |
| GABRR2 | OR10H3 | 0.721353 | 4 | 0 | 4 |
| GABRR2 | UBE2D4 | 0.719809 | 4 | 0 | 4 |
For details and further investigation, click here
