| Full name: lin-7 homolog A, crumbs cell polarity complex component | Alias Symbol: MALS-1|TIP-33|LIN-7A|VELI1 | ||
| Type: protein-coding gene | Cytoband: 12q21.31 | ||
| Entrez ID: 8825 | HGNC ID: HGNC:17787 | Ensembl Gene: ENSG00000111052 | OMIM ID: 603380 |
| Drug and gene relationship at DGIdb | |||
Expression of LIN7A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIN7A | 8825 | 227929_at | -0.4385 | 0.5958 | |
| GSE20347 | LIN7A | 8825 | 206440_at | -0.0420 | 0.6157 | |
| GSE23400 | LIN7A | 8825 | 206440_at | -0.0686 | 0.0212 | |
| GSE26886 | LIN7A | 8825 | 206440_at | 0.8569 | 0.0179 | |
| GSE29001 | LIN7A | 8825 | 206440_at | 0.0465 | 0.7843 | |
| GSE38129 | LIN7A | 8825 | 206440_at | -0.1599 | 0.1495 | |
| GSE45670 | LIN7A | 8825 | 227929_at | -0.5206 | 0.0502 | |
| GSE53622 | LIN7A | 8825 | 129848 | 0.0795 | 0.5994 | |
| GSE53624 | LIN7A | 8825 | 129848 | 0.4285 | 0.0037 | |
| GSE63941 | LIN7A | 8825 | 206440_at | -1.3625 | 0.0335 | |
| GSE77861 | LIN7A | 8825 | 206440_at | -0.0220 | 0.8393 | |
| GSE97050 | LIN7A | 8825 | A_23_P99253 | -0.2455 | 0.5932 | |
| SRP007169 | LIN7A | 8825 | RNAseq | 2.5374 | 0.0024 | |
| SRP008496 | LIN7A | 8825 | RNAseq | 2.8664 | 0.0001 | |
| SRP064894 | LIN7A | 8825 | RNAseq | 0.8872 | 0.0156 | |
| SRP133303 | LIN7A | 8825 | RNAseq | 0.5065 | 0.0805 | |
| SRP159526 | LIN7A | 8825 | RNAseq | 1.5017 | 0.0157 | |
| SRP193095 | LIN7A | 8825 | RNAseq | 1.8381 | 0.0000 | |
| SRP219564 | LIN7A | 8825 | RNAseq | -0.1369 | 0.8193 | |
| TCGA | LIN7A | 8825 | RNAseq | -0.5932 | 0.1888 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by LIN7A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LIN7A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIN7A | 8825 | 2 | 4 | 24 | |
| GSE20123 | LIN7A | 8825 | 2 | 4 | 24 | |
| GSE43470 | LIN7A | 8825 | 3 | 1 | 39 | |
| GSE46452 | LIN7A | 8825 | 9 | 1 | 49 | |
| GSE47630 | LIN7A | 8825 | 10 | 1 | 29 | |
| GSE54993 | LIN7A | 8825 | 0 | 5 | 65 | |
| GSE54994 | LIN7A | 8825 | 7 | 1 | 45 | |
| GSE60625 | LIN7A | 8825 | 0 | 0 | 11 | |
| GSE74703 | LIN7A | 8825 | 3 | 1 | 32 | |
| GSE74704 | LIN7A | 8825 | 1 | 3 | 16 | |
| TCGA | LIN7A | 8825 | 15 | 13 | 68 |
Total number of gains: 52; Total number of losses: 34; Total Number of normals: 402.
Somatic mutations of LIN7A:
Generating mutation plots.
Highly correlated genes for LIN7A:
Showing top 20/887 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIN7A | KAT7 | 0.799214 | 3 | 0 | 3 |
| LIN7A | FIBIN | 0.795386 | 4 | 0 | 4 |
| LIN7A | KLF11 | 0.789706 | 3 | 0 | 3 |
| LIN7A | SPATA9 | 0.758166 | 3 | 0 | 3 |
| LIN7A | IDS | 0.755065 | 3 | 0 | 3 |
| LIN7A | LNP1 | 0.743262 | 3 | 0 | 3 |
| LIN7A | KLF2 | 0.741291 | 5 | 0 | 4 |
| LIN7A | CNRIP1 | 0.738722 | 6 | 0 | 6 |
| LIN7A | MCAM | 0.738519 | 5 | 0 | 4 |
| LIN7A | TYW3 | 0.728617 | 3 | 0 | 3 |
| LIN7A | KCNJ8 | 0.721896 | 7 | 0 | 6 |
| LIN7A | CNTLN | 0.717835 | 5 | 0 | 5 |
| LIN7A | FAM49A | 0.715799 | 3 | 0 | 3 |
| LIN7A | GRIN3A | 0.710908 | 3 | 0 | 3 |
| LIN7A | FUNDC2 | 0.709901 | 4 | 0 | 3 |
| LIN7A | CNTN3 | 0.708088 | 3 | 0 | 3 |
| LIN7A | ZNF334 | 0.707084 | 4 | 0 | 3 |
| LIN7A | TTC33 | 0.704569 | 3 | 0 | 3 |
| LIN7A | KIAA2013 | 0.704522 | 3 | 0 | 3 |
| LIN7A | PWAR5 | 0.704296 | 3 | 0 | 3 |
For details and further investigation, click here
