PLCB4

 

Full name: phospholipase C beta 4 Alias Symbol: 
Type: protein-coding gene Cytoband: 20p12.3-p12.2
Entrez ID: 5332 HGNC ID: HGNC:9059 Ensembl Gene: ENSG00000101333 OMIM ID: 600810
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PLCB4 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04062Chemokine signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
hsa05016Huntington's disease
hsa05142Chagas disease (American trypanosomiasis)

 

Expression of PLCB4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLCB4 5332 203895_at -2.4754 0.0435
GSE20347 PLCB4 5332 203895_at 0.2015 0.6630
GSE23400 PLCB4 5332 203895_at -0.3079 0.0089
GSE26886 PLCB4 5332 203895_at 1.6091 0.0119
GSE29001 PLCB4 5332 203895_at 0.0575 0.9246
GSE38129 PLCB4 5332 203895_at -0.6227 0.2426
GSE45670 PLCB4 5332 203896_s_at -3.0339 0.0000
GSE53622 PLCB4 5332 94279 -1.5883 0.0000
GSE53624 PLCB4 5332 94279 -1.5265 0.0000
GSE63941 PLCB4 5332 203895_at -2.1142 0.1496
GSE77861 PLCB4 5332 203895_at 0.4778 0.1604
GSE97050 PLCB4 5332 A_33_P3353502 -1.8943 0.0695
SRP064894 PLCB4 5332 RNAseq -1.6608 0.0000
SRP133303 PLCB4 5332 RNAseq -1.4425 0.0114
SRP159526 PLCB4 5332 RNAseq 1.7127 0.0152
SRP219564 PLCB4 5332 RNAseq -0.9355 0.2650
TCGA PLCB4 5332 RNAseq -0.9929 0.0001

Upregulated datasets: 2; Downregulated datasets: 6.  

 

Survival by PLCB4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLCB4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLCB4 5332 9 1 20
GSE20123 PLCB4 5332 9 1 20
GSE43470 PLCB4 5332 11 1 31
GSE46452 PLCB4 5332 26 1 32
GSE47630 PLCB4 5332 18 4 18
GSE54993 PLCB4 5332 1 14 55
GSE54994 PLCB4 5332 25 1 27
GSE60625 PLCB4 5332 0 0 11
GSE74703 PLCB4 5332 8 1 27
GSE74704 PLCB4 5332 4 1 15
TCGA PLCB4 5332 42 11 43

Total number of gains: 153; Total number of losses: 36; Total Number of normals: 299.  

 

Somatic mutations of PLCB4:

 

Generating mutation plots.

 

Highly correlated genes for PLCB4:

 

Showing top 20/976 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLCB4SMOC20.802212707
PLCB4LONRF20.785866505
PLCB4CHRDL10.766222707
PLCB4CNN10.761703707
PLCB4MICU30.755255606
PLCB4CASQ20.754943707
PLCB4PDK20.754914303
PLCB4KCND30.751865303
PLCB4AOC30.74679808
PLCB4FGF14-AS20.745164505
PLCB4EPDR10.743251404
PLCB4ADAMTS9-AS20.742947404
PLCB4CBX70.74165808
PLCB4ABCA80.739513807
PLCB4RNF1500.736595707
PLCB4MSRB30.730939606
PLCB4UTRN0.730878606
PLCB4C70.730694807
PLCB4TCEAL30.729461303
PLCB4SORCS10.727068404

For details and further investigation, click here