| Full name: pleckstrin homology and FYVE domain containing 1 | Alias Symbol: APPD|MGC4090|PHAFIN1|ZFYVE15 | ||
| Type: protein-coding gene | Cytoband: 19q12 | ||
| Entrez ID: 79156 | HGNC ID: HGNC:20764 | Ensembl Gene: ENSG00000166289 | OMIM ID: 615200 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHF1 | 79156 | 219566_at | -0.3048 | 0.2802 | |
| GSE20347 | PLEKHF1 | 79156 | 219566_at | -0.4712 | 0.0157 | |
| GSE23400 | PLEKHF1 | 79156 | 219566_at | -0.3080 | 0.0000 | |
| GSE26886 | PLEKHF1 | 79156 | 219566_at | -0.4195 | 0.0732 | |
| GSE29001 | PLEKHF1 | 79156 | 219566_at | -0.1207 | 0.5735 | |
| GSE38129 | PLEKHF1 | 79156 | 219566_at | -0.5872 | 0.0002 | |
| GSE45670 | PLEKHF1 | 79156 | 219566_at | -0.2735 | 0.1606 | |
| GSE53622 | PLEKHF1 | 79156 | 6406 | -0.3583 | 0.0001 | |
| GSE53624 | PLEKHF1 | 79156 | 6406 | -0.4240 | 0.0000 | |
| GSE63941 | PLEKHF1 | 79156 | 219566_at | 0.1812 | 0.7405 | |
| GSE77861 | PLEKHF1 | 79156 | 219566_at | -0.3544 | 0.2485 | |
| GSE97050 | PLEKHF1 | 79156 | A_23_P79134 | -0.0367 | 0.9371 | |
| SRP007169 | PLEKHF1 | 79156 | RNAseq | -2.6031 | 0.0004 | |
| SRP008496 | PLEKHF1 | 79156 | RNAseq | -2.8692 | 0.0000 | |
| SRP064894 | PLEKHF1 | 79156 | RNAseq | -0.8036 | 0.0163 | |
| SRP133303 | PLEKHF1 | 79156 | RNAseq | -0.5901 | 0.1201 | |
| SRP159526 | PLEKHF1 | 79156 | RNAseq | -1.5930 | 0.0000 | |
| SRP193095 | PLEKHF1 | 79156 | RNAseq | -0.2834 | 0.2872 | |
| SRP219564 | PLEKHF1 | 79156 | RNAseq | -1.0252 | 0.0294 | |
| TCGA | PLEKHF1 | 79156 | RNAseq | 0.2373 | 0.0544 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by PLEKHF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHF1 | 79156 | 6 | 7 | 17 | |
| GSE20123 | PLEKHF1 | 79156 | 6 | 6 | 18 | |
| GSE43470 | PLEKHF1 | 79156 | 6 | 6 | 31 | |
| GSE46452 | PLEKHF1 | 79156 | 47 | 1 | 11 | |
| GSE47630 | PLEKHF1 | 79156 | 8 | 6 | 26 | |
| GSE54993 | PLEKHF1 | 79156 | 17 | 3 | 50 | |
| GSE54994 | PLEKHF1 | 79156 | 7 | 11 | 35 | |
| GSE60625 | PLEKHF1 | 79156 | 9 | 0 | 2 | |
| GSE74703 | PLEKHF1 | 79156 | 6 | 4 | 26 | |
| GSE74704 | PLEKHF1 | 79156 | 5 | 4 | 11 | |
| TCGA | PLEKHF1 | 79156 | 17 | 14 | 65 |
Total number of gains: 134; Total number of losses: 62; Total Number of normals: 292.
Somatic mutations of PLEKHF1:
Generating mutation plots.
Highly correlated genes for PLEKHF1:
Showing top 20/134 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHF1 | SRCIN1 | 0.667049 | 3 | 0 | 3 |
| PLEKHF1 | EPO | 0.664079 | 3 | 0 | 3 |
| PLEKHF1 | PRSS8 | 0.627721 | 7 | 0 | 6 |
| PLEKHF1 | TMEM125 | 0.627643 | 3 | 0 | 3 |
| PLEKHF1 | TAS2R3 | 0.623259 | 4 | 0 | 4 |
| PLEKHF1 | ST8SIA3 | 0.621446 | 4 | 0 | 3 |
| PLEKHF1 | TAMM41 | 0.617334 | 3 | 0 | 3 |
| PLEKHF1 | BCKDHA | 0.610829 | 7 | 0 | 5 |
| PLEKHF1 | KCNJ13 | 0.609899 | 3 | 0 | 3 |
| PLEKHF1 | MYO5B | 0.609711 | 4 | 0 | 3 |
| PLEKHF1 | NR1I3 | 0.607828 | 6 | 0 | 4 |
| PLEKHF1 | MYO15B | 0.605782 | 5 | 0 | 5 |
| PLEKHF1 | CNTD2 | 0.605771 | 3 | 0 | 3 |
| PLEKHF1 | FRMPD1 | 0.602956 | 3 | 0 | 3 |
| PLEKHF1 | GPR50 | 0.602163 | 5 | 0 | 4 |
| PLEKHF1 | UPK3A | 0.602158 | 3 | 0 | 3 |
| PLEKHF1 | JMJD8 | 0.600735 | 4 | 0 | 3 |
| PLEKHF1 | TNNT3 | 0.596459 | 4 | 0 | 3 |
| PLEKHF1 | CCDC33 | 0.596087 | 3 | 0 | 3 |
| PLEKHF1 | EPOR | 0.595297 | 3 | 0 | 3 |
For details and further investigation, click here
