| Full name: serine protease 8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 5652 | HGNC ID: HGNC:9491 | Ensembl Gene: ENSG00000052344 | OMIM ID: 600823 |
| Drug and gene relationship at DGIdb | |||
Expression of PRSS8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRSS8 | 5652 | 202525_at | -0.5853 | 0.2743 | |
| GSE20347 | PRSS8 | 5652 | 202525_at | -1.4986 | 0.0000 | |
| GSE23400 | PRSS8 | 5652 | 202525_at | -1.0758 | 0.0000 | |
| GSE26886 | PRSS8 | 5652 | 202525_at | -2.2625 | 0.0000 | |
| GSE29001 | PRSS8 | 5652 | 202525_at | -1.2371 | 0.0001 | |
| GSE38129 | PRSS8 | 5652 | 202525_at | -0.7910 | 0.0376 | |
| GSE45670 | PRSS8 | 5652 | 202525_at | -0.2829 | 0.2746 | |
| GSE63941 | PRSS8 | 5652 | 202525_at | 3.4585 | 0.0040 | |
| GSE77861 | PRSS8 | 5652 | 202525_at | -1.1515 | 0.0226 | |
| GSE97050 | PRSS8 | 5652 | A_33_P3329088 | 0.2108 | 0.7479 | |
| SRP007169 | PRSS8 | 5652 | RNAseq | -3.2436 | 0.0000 | |
| SRP008496 | PRSS8 | 5652 | RNAseq | -3.1919 | 0.0000 | |
| SRP064894 | PRSS8 | 5652 | RNAseq | -2.1654 | 0.0000 | |
| SRP133303 | PRSS8 | 5652 | RNAseq | -1.5798 | 0.0000 | |
| SRP159526 | PRSS8 | 5652 | RNAseq | -1.7717 | 0.0003 | |
| SRP193095 | PRSS8 | 5652 | RNAseq | -1.8213 | 0.0000 | |
| SRP219564 | PRSS8 | 5652 | RNAseq | -1.2606 | 0.2265 | |
| TCGA | PRSS8 | 5652 | RNAseq | -0.2955 | 0.1159 |
Upregulated datasets: 1; Downregulated datasets: 11.
Survival by PRSS8 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PRSS8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRSS8 | 5652 | 4 | 5 | 21 | |
| GSE20123 | PRSS8 | 5652 | 4 | 4 | 22 | |
| GSE43470 | PRSS8 | 5652 | 3 | 3 | 37 | |
| GSE46452 | PRSS8 | 5652 | 38 | 1 | 20 | |
| GSE47630 | PRSS8 | 5652 | 11 | 7 | 22 | |
| GSE54993 | PRSS8 | 5652 | 2 | 5 | 63 | |
| GSE54994 | PRSS8 | 5652 | 5 | 9 | 39 | |
| GSE60625 | PRSS8 | 5652 | 4 | 0 | 7 | |
| GSE74703 | PRSS8 | 5652 | 3 | 2 | 31 | |
| GSE74704 | PRSS8 | 5652 | 3 | 2 | 15 | |
| TCGA | PRSS8 | 5652 | 20 | 10 | 66 |
Total number of gains: 97; Total number of losses: 48; Total Number of normals: 343.
Somatic mutations of PRSS8:
Generating mutation plots.
Highly correlated genes for PRSS8:
Showing top 20/903 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRSS8 | EPS8L2 | 0.808048 | 9 | 0 | 9 |
| PRSS8 | SPINT1 | 0.797377 | 9 | 0 | 9 |
| PRSS8 | SCNN1B | 0.792106 | 9 | 0 | 9 |
| PRSS8 | EVPL | 0.78184 | 11 | 0 | 10 |
| PRSS8 | TMEM154 | 0.781285 | 5 | 0 | 5 |
| PRSS8 | C6orf132 | 0.779768 | 6 | 0 | 6 |
| PRSS8 | RAB25 | 0.776233 | 9 | 0 | 9 |
| PRSS8 | TRIP10 | 0.775421 | 9 | 0 | 9 |
| PRSS8 | PIM1 | 0.770894 | 8 | 0 | 8 |
| PRSS8 | MYO5B | 0.770683 | 6 | 0 | 6 |
| PRSS8 | CRCT1 | 0.764788 | 10 | 0 | 10 |
| PRSS8 | MXD1 | 0.764076 | 10 | 0 | 9 |
| PRSS8 | SNX24 | 0.762415 | 9 | 0 | 9 |
| PRSS8 | SLC35C1 | 0.7622 | 9 | 0 | 9 |
| PRSS8 | PTK6 | 0.759206 | 11 | 0 | 11 |
| PRSS8 | TECR | 0.751778 | 10 | 0 | 10 |
| PRSS8 | IL1RN | 0.751303 | 10 | 0 | 10 |
| PRSS8 | SH3GL1 | 0.749729 | 9 | 0 | 8 |
| PRSS8 | TMEM40 | 0.748821 | 10 | 0 | 10 |
| PRSS8 | EPS8L1 | 0.748032 | 11 | 0 | 11 |
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