| Full name: pleckstrin homology, MyTH4 and FERM domain containing H3 | Alias Symbol: FLJ21019 | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 79990 | HGNC ID: HGNC:26105 | Ensembl Gene: ENSG00000068137 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHH3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHH3 | 79990 | 227248_at | -0.0015 | 0.9973 | |
| GSE20347 | PLEKHH3 | 79990 | 220259_at | -0.1492 | 0.0290 | |
| GSE23400 | PLEKHH3 | 79990 | 220259_at | -0.1474 | 0.0000 | |
| GSE26886 | PLEKHH3 | 79990 | 227248_at | -0.0264 | 0.8682 | |
| GSE29001 | PLEKHH3 | 79990 | 220259_at | -0.1205 | 0.4461 | |
| GSE38129 | PLEKHH3 | 79990 | 220259_at | -0.0603 | 0.4271 | |
| GSE45670 | PLEKHH3 | 79990 | 227248_at | 0.0341 | 0.8262 | |
| GSE53622 | PLEKHH3 | 79990 | 27642 | -0.3242 | 0.0000 | |
| GSE53624 | PLEKHH3 | 79990 | 27642 | -0.4540 | 0.0000 | |
| GSE63941 | PLEKHH3 | 79990 | 227248_at | 0.4228 | 0.0834 | |
| GSE77861 | PLEKHH3 | 79990 | 227248_at | 0.0302 | 0.7943 | |
| GSE97050 | PLEKHH3 | 79990 | A_33_P3254946 | 0.0355 | 0.9354 | |
| SRP007169 | PLEKHH3 | 79990 | RNAseq | -1.4415 | 0.0001 | |
| SRP008496 | PLEKHH3 | 79990 | RNAseq | -1.2342 | 0.0000 | |
| SRP064894 | PLEKHH3 | 79990 | RNAseq | -0.5523 | 0.0027 | |
| SRP133303 | PLEKHH3 | 79990 | RNAseq | -0.7834 | 0.0001 | |
| SRP159526 | PLEKHH3 | 79990 | RNAseq | -0.8686 | 0.0004 | |
| SRP193095 | PLEKHH3 | 79990 | RNAseq | -0.6214 | 0.0000 | |
| SRP219564 | PLEKHH3 | 79990 | RNAseq | -0.7656 | 0.0579 | |
| TCGA | PLEKHH3 | 79990 | RNAseq | -0.0917 | 0.1378 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PLEKHH3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHH3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHH3 | 79990 | 6 | 2 | 22 | |
| GSE20123 | PLEKHH3 | 79990 | 6 | 2 | 22 | |
| GSE43470 | PLEKHH3 | 79990 | 1 | 2 | 40 | |
| GSE46452 | PLEKHH3 | 79990 | 34 | 0 | 25 | |
| GSE47630 | PLEKHH3 | 79990 | 8 | 1 | 31 | |
| GSE54993 | PLEKHH3 | 79990 | 3 | 4 | 63 | |
| GSE54994 | PLEKHH3 | 79990 | 8 | 5 | 40 | |
| GSE60625 | PLEKHH3 | 79990 | 4 | 0 | 7 | |
| GSE74703 | PLEKHH3 | 79990 | 1 | 1 | 34 | |
| GSE74704 | PLEKHH3 | 79990 | 4 | 1 | 15 | |
| TCGA | PLEKHH3 | 79990 | 23 | 6 | 67 |
Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.
Somatic mutations of PLEKHH3:
Generating mutation plots.
Highly correlated genes for PLEKHH3:
Showing top 20/188 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHH3 | DHH | 0.671915 | 3 | 0 | 3 |
| PLEKHH3 | CC2D1B | 0.67112 | 3 | 0 | 3 |
| PLEKHH3 | BUD13 | 0.668516 | 3 | 0 | 3 |
| PLEKHH3 | MAT1A | 0.667432 | 4 | 0 | 4 |
| PLEKHH3 | RASSF6 | 0.665405 | 3 | 0 | 3 |
| PLEKHH3 | HHLA2 | 0.660476 | 4 | 0 | 3 |
| PLEKHH3 | CABP7 | 0.656172 | 3 | 0 | 3 |
| PLEKHH3 | USHBP1 | 0.651984 | 4 | 0 | 3 |
| PLEKHH3 | SPATA19 | 0.648121 | 3 | 0 | 3 |
| PLEKHH3 | ASB10 | 0.643831 | 4 | 0 | 3 |
| PLEKHH3 | CNTD2 | 0.638813 | 4 | 0 | 3 |
| PLEKHH3 | TEX13B | 0.637898 | 4 | 0 | 3 |
| PLEKHH3 | CBR3-AS1 | 0.636293 | 4 | 0 | 4 |
| PLEKHH3 | CBLN4 | 0.636217 | 4 | 0 | 3 |
| PLEKHH3 | C20orf141 | 0.626318 | 4 | 0 | 3 |
| PLEKHH3 | SPAG4 | 0.620375 | 3 | 0 | 3 |
| PLEKHH3 | RAB11FIP4 | 0.620215 | 5 | 0 | 5 |
| PLEKHH3 | PYY | 0.61956 | 4 | 0 | 3 |
| PLEKHH3 | LGI4 | 0.613739 | 3 | 0 | 3 |
| PLEKHH3 | GRIK5 | 0.611429 | 5 | 0 | 3 |
For details and further investigation, click here
