| Full name: sperm associated antigen 4 | Alias Symbol: SUN4|CT127 | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 6676 | HGNC ID: HGNC:11214 | Ensembl Gene: ENSG00000061656 | OMIM ID: 603038 |
| Drug and gene relationship at DGIdb | |||
Expression of SPAG4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPAG4 | 6676 | 219888_at | 0.3063 | 0.7241 | |
| GSE20347 | SPAG4 | 6676 | 219888_at | 0.1161 | 0.4387 | |
| GSE23400 | SPAG4 | 6676 | 219888_at | 0.0279 | 0.6710 | |
| GSE26886 | SPAG4 | 6676 | 219888_at | -0.4056 | 0.0123 | |
| GSE29001 | SPAG4 | 6676 | 219888_at | -0.1993 | 0.5336 | |
| GSE38129 | SPAG4 | 6676 | 219888_at | 0.2712 | 0.1899 | |
| GSE45670 | SPAG4 | 6676 | 219888_at | 0.3937 | 0.1490 | |
| GSE53622 | SPAG4 | 6676 | 17897 | -0.0978 | 0.6192 | |
| GSE53624 | SPAG4 | 6676 | 17897 | -0.1873 | 0.0960 | |
| GSE63941 | SPAG4 | 6676 | 219888_at | 0.3858 | 0.7449 | |
| GSE77861 | SPAG4 | 6676 | 219888_at | -0.0238 | 0.8868 | |
| GSE97050 | SPAG4 | 6676 | A_23_P132027 | 0.1779 | 0.5675 | |
| SRP064894 | SPAG4 | 6676 | RNAseq | 0.7377 | 0.0292 | |
| SRP133303 | SPAG4 | 6676 | RNAseq | 0.3358 | 0.1622 | |
| SRP159526 | SPAG4 | 6676 | RNAseq | 1.0915 | 0.0487 | |
| SRP193095 | SPAG4 | 6676 | RNAseq | 0.1420 | 0.6097 | |
| SRP219564 | SPAG4 | 6676 | RNAseq | 0.2568 | 0.5431 | |
| TCGA | SPAG4 | 6676 | RNAseq | 0.0010 | 0.9968 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SPAG4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPAG4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPAG4 | 6676 | 15 | 1 | 14 | |
| GSE20123 | SPAG4 | 6676 | 15 | 1 | 14 | |
| GSE43470 | SPAG4 | 6676 | 12 | 0 | 31 | |
| GSE46452 | SPAG4 | 6676 | 29 | 0 | 30 | |
| GSE47630 | SPAG4 | 6676 | 25 | 0 | 15 | |
| GSE54993 | SPAG4 | 6676 | 0 | 17 | 53 | |
| GSE54994 | SPAG4 | 6676 | 24 | 0 | 29 | |
| GSE60625 | SPAG4 | 6676 | 0 | 0 | 11 | |
| GSE74703 | SPAG4 | 6676 | 11 | 0 | 25 | |
| GSE74704 | SPAG4 | 6676 | 11 | 0 | 9 | |
| TCGA | SPAG4 | 6676 | 49 | 3 | 44 |
Total number of gains: 191; Total number of losses: 22; Total Number of normals: 275.
Somatic mutations of SPAG4:
Generating mutation plots.
Highly correlated genes for SPAG4:
Showing top 20/46 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPAG4 | ARHGAP30 | 0.731581 | 3 | 0 | 3 |
| SPAG4 | ADCK5 | 0.706903 | 3 | 0 | 3 |
| SPAG4 | CYTH1 | 0.688388 | 4 | 0 | 3 |
| SPAG4 | CD247 | 0.670041 | 3 | 0 | 3 |
| SPAG4 | MOCOS | 0.660819 | 5 | 0 | 4 |
| SPAG4 | PPIL2 | 0.655372 | 3 | 0 | 3 |
| SPAG4 | CDH26 | 0.640716 | 3 | 0 | 3 |
| SPAG4 | SP6 | 0.637495 | 3 | 0 | 3 |
| SPAG4 | FCHSD1 | 0.633909 | 6 | 0 | 5 |
| SPAG4 | GPSM3 | 0.632678 | 4 | 0 | 3 |
| SPAG4 | SEMA3F | 0.626443 | 4 | 0 | 3 |
| SPAG4 | SIGLEC10 | 0.622309 | 4 | 0 | 3 |
| SPAG4 | PLEKHH3 | 0.620375 | 3 | 0 | 3 |
| SPAG4 | MFNG | 0.614639 | 5 | 0 | 3 |
| SPAG4 | SHD | 0.613962 | 4 | 0 | 3 |
| SPAG4 | GALK1 | 0.612049 | 5 | 0 | 3 |
| SPAG4 | ABCA4 | 0.600687 | 4 | 0 | 3 |
| SPAG4 | CHI3L2 | 0.598683 | 5 | 0 | 3 |
| SPAG4 | ERMP1 | 0.596034 | 5 | 0 | 4 |
| SPAG4 | SCNN1B | 0.593888 | 3 | 0 | 3 |
For details and further investigation, click here
