| Full name: HERV-H LTR-associating 2 | Alias Symbol: B7H7|B7-H5|B7y | ||
| Type: protein-coding gene | Cytoband: 3q13.13 | ||
| Entrez ID: 11148 | HGNC ID: HGNC:4905 | Ensembl Gene: ENSG00000114455 | OMIM ID: 604371 |
| Drug and gene relationship at DGIdb | |||
Expression of HHLA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HHLA2 | 11148 | 220812_s_at | -0.0154 | 0.9588 | |
| GSE20347 | HHLA2 | 11148 | 220812_s_at | -0.0204 | 0.7202 | |
| GSE23400 | HHLA2 | 11148 | 220812_s_at | -0.0722 | 0.0000 | |
| GSE26886 | HHLA2 | 11148 | 220812_s_at | -0.0062 | 0.9528 | |
| GSE29001 | HHLA2 | 11148 | 220812_s_at | -0.0707 | 0.4416 | |
| GSE38129 | HHLA2 | 11148 | 220812_s_at | -0.0543 | 0.2254 | |
| GSE45670 | HHLA2 | 11148 | 220812_s_at | -0.0864 | 0.2037 | |
| GSE53622 | HHLA2 | 11148 | 108280 | 0.3938 | 0.0446 | |
| GSE53624 | HHLA2 | 11148 | 108280 | 0.1738 | 0.0788 | |
| GSE63941 | HHLA2 | 11148 | 220812_s_at | 0.1836 | 0.2569 | |
| GSE77861 | HHLA2 | 11148 | 234673_at | -0.0085 | 0.9315 | |
| SRP007169 | HHLA2 | 11148 | RNAseq | 0.3500 | 0.6570 | |
| SRP133303 | HHLA2 | 11148 | RNAseq | 0.3972 | 0.1543 | |
| SRP159526 | HHLA2 | 11148 | RNAseq | 0.9427 | 0.2339 | |
| TCGA | HHLA2 | 11148 | RNAseq | -2.5970 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HHLA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HHLA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HHLA2 | 11148 | 18 | 1 | 11 | |
| GSE20123 | HHLA2 | 11148 | 17 | 1 | 12 | |
| GSE43470 | HHLA2 | 11148 | 18 | 1 | 24 | |
| GSE46452 | HHLA2 | 11148 | 12 | 6 | 41 | |
| GSE47630 | HHLA2 | 11148 | 16 | 6 | 18 | |
| GSE54993 | HHLA2 | 11148 | 2 | 5 | 63 | |
| GSE54994 | HHLA2 | 11148 | 28 | 5 | 20 | |
| GSE60625 | HHLA2 | 11148 | 0 | 6 | 5 | |
| GSE74703 | HHLA2 | 11148 | 15 | 1 | 20 | |
| GSE74704 | HHLA2 | 11148 | 14 | 1 | 5 | |
| TCGA | HHLA2 | 11148 | 50 | 8 | 38 |
Total number of gains: 190; Total number of losses: 41; Total Number of normals: 257.
Somatic mutations of HHLA2:
Generating mutation plots.
Highly correlated genes for HHLA2:
Showing top 20/109 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HHLA2 | PLEKHH3 | 0.660476 | 4 | 0 | 3 |
| HHLA2 | ART1 | 0.635666 | 3 | 0 | 3 |
| HHLA2 | UPK2 | 0.62972 | 3 | 0 | 3 |
| HHLA2 | ANKRD53 | 0.623177 | 3 | 0 | 3 |
| HHLA2 | GDF3 | 0.621637 | 3 | 0 | 3 |
| HHLA2 | TAOK2 | 0.616337 | 4 | 0 | 3 |
| HHLA2 | ACBD4 | 0.609924 | 3 | 0 | 3 |
| HHLA2 | GIPC1 | 0.609812 | 4 | 0 | 4 |
| HHLA2 | ZBTB7B | 0.609136 | 4 | 0 | 3 |
| HHLA2 | CT62 | 0.603326 | 4 | 0 | 3 |
| HHLA2 | TREML2 | 0.603042 | 3 | 0 | 3 |
| HHLA2 | GBX2 | 0.601305 | 4 | 0 | 3 |
| HHLA2 | MYOG | 0.597178 | 4 | 0 | 3 |
| HHLA2 | ADRB1 | 0.596433 | 4 | 0 | 3 |
| HHLA2 | CST5 | 0.595626 | 3 | 0 | 3 |
| HHLA2 | DLX6 | 0.594146 | 4 | 0 | 4 |
| HHLA2 | AQP5 | 0.593211 | 3 | 0 | 3 |
| HHLA2 | SPIN2A | 0.592009 | 3 | 0 | 3 |
| HHLA2 | GHRH | 0.591544 | 3 | 0 | 3 |
| HHLA2 | CDHR5 | 0.590461 | 3 | 0 | 3 |
For details and further investigation, click here
