| Full name: DNA polymerase lambda | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q24.32 | ||
| Entrez ID: 27343 | HGNC ID: HGNC:9184 | Ensembl Gene: ENSG00000166169 | OMIM ID: 606343 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of POLL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLL | 27343 | 221049_s_at | -0.0910 | 0.8368 | |
| GSE20347 | POLL | 27343 | 221049_s_at | 0.0156 | 0.8691 | |
| GSE23400 | POLL | 27343 | 221049_s_at | -0.1143 | 0.0013 | |
| GSE26886 | POLL | 27343 | 221049_s_at | -0.0097 | 0.9500 | |
| GSE29001 | POLL | 27343 | 221049_s_at | -0.0559 | 0.8051 | |
| GSE38129 | POLL | 27343 | 221049_s_at | -0.1122 | 0.1815 | |
| GSE45670 | POLL | 27343 | 221049_s_at | -0.0083 | 0.9398 | |
| GSE53622 | POLL | 27343 | 35457 | -0.0859 | 0.1435 | |
| GSE53624 | POLL | 27343 | 35457 | 0.0619 | 0.4356 | |
| GSE63941 | POLL | 27343 | 221049_s_at | 0.0003 | 0.9988 | |
| GSE77861 | POLL | 27343 | 221049_s_at | -0.0848 | 0.6335 | |
| GSE97050 | POLL | 27343 | A_33_P3282669 | -0.1376 | 0.5250 | |
| SRP007169 | POLL | 27343 | RNAseq | -0.2740 | 0.5730 | |
| SRP008496 | POLL | 27343 | RNAseq | -0.0354 | 0.9177 | |
| SRP064894 | POLL | 27343 | RNAseq | 0.2024 | 0.4073 | |
| SRP133303 | POLL | 27343 | RNAseq | -0.3262 | 0.0693 | |
| SRP159526 | POLL | 27343 | RNAseq | 0.0212 | 0.9081 | |
| SRP193095 | POLL | 27343 | RNAseq | -0.0160 | 0.8628 | |
| SRP219564 | POLL | 27343 | RNAseq | 0.0470 | 0.9176 | |
| TCGA | POLL | 27343 | RNAseq | -0.2435 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POLL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLL | 27343 | 2 | 9 | 19 | |
| GSE20123 | POLL | 27343 | 2 | 8 | 20 | |
| GSE43470 | POLL | 27343 | 0 | 8 | 35 | |
| GSE46452 | POLL | 27343 | 0 | 11 | 48 | |
| GSE47630 | POLL | 27343 | 2 | 14 | 24 | |
| GSE54993 | POLL | 27343 | 8 | 0 | 62 | |
| GSE54994 | POLL | 27343 | 1 | 12 | 40 | |
| GSE60625 | POLL | 27343 | 0 | 0 | 11 | |
| GSE74703 | POLL | 27343 | 0 | 5 | 31 | |
| GSE74704 | POLL | 27343 | 1 | 4 | 15 | |
| TCGA | POLL | 27343 | 5 | 28 | 63 |
Total number of gains: 21; Total number of losses: 99; Total Number of normals: 368.
Somatic mutations of POLL:
Generating mutation plots.
Highly correlated genes for POLL:
Showing top 20/398 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLL | SETD1B | 0.858 | 3 | 0 | 3 |
| POLL | SPATA2L | 0.770402 | 3 | 0 | 3 |
| POLL | SLC25A47 | 0.767759 | 4 | 0 | 4 |
| POLL | RLN3 | 0.75792 | 3 | 0 | 3 |
| POLL | FASTK | 0.755556 | 3 | 0 | 3 |
| POLL | RAB40B | 0.750457 | 3 | 0 | 3 |
| POLL | SLC22A31 | 0.749584 | 3 | 0 | 3 |
| POLL | TBX21 | 0.740144 | 3 | 0 | 3 |
| POLL | DNAL4 | 0.738242 | 3 | 0 | 3 |
| POLL | LENG1 | 0.727741 | 3 | 0 | 3 |
| POLL | SURF2 | 0.722581 | 3 | 0 | 3 |
| POLL | ABHD11 | 0.712327 | 3 | 0 | 3 |
| POLL | NTNG2 | 0.712156 | 3 | 0 | 3 |
| POLL | DUSP15 | 0.710445 | 3 | 0 | 3 |
| POLL | QRICH2 | 0.708491 | 4 | 0 | 4 |
| POLL | RNF215 | 0.704584 | 3 | 0 | 3 |
| POLL | ABCC6 | 0.70425 | 4 | 0 | 3 |
| POLL | EML2 | 0.70046 | 3 | 0 | 3 |
| POLL | CRYBB3 | 0.698169 | 4 | 0 | 3 |
| POLL | DCD | 0.697482 | 3 | 0 | 3 |
For details and further investigation, click here
