| Full name: dynein axonemal light chain 4 | Alias Symbol: dJ327J16|PIG27 | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 10126 | HGNC ID: HGNC:2955 | Ensembl Gene: ENSG00000100246 | OMIM ID: 610565 |
| Drug and gene relationship at DGIdb | |||
Expression of DNAL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNAL4 | 10126 | 204008_at | 0.3269 | 0.3700 | |
| GSE20347 | DNAL4 | 10126 | 204008_at | -0.0340 | 0.8815 | |
| GSE23400 | DNAL4 | 10126 | 204008_at | 0.0355 | 0.4498 | |
| GSE26886 | DNAL4 | 10126 | 204008_at | 0.1123 | 0.4914 | |
| GSE29001 | DNAL4 | 10126 | 204008_at | -0.0994 | 0.6851 | |
| GSE38129 | DNAL4 | 10126 | 204008_at | 0.1401 | 0.2833 | |
| GSE45670 | DNAL4 | 10126 | 204008_at | 0.1081 | 0.3830 | |
| GSE53622 | DNAL4 | 10126 | 133918 | 0.1990 | 0.0606 | |
| GSE53624 | DNAL4 | 10126 | 133918 | 0.1136 | 0.2458 | |
| GSE63941 | DNAL4 | 10126 | 204008_at | 0.3576 | 0.4381 | |
| GSE77861 | DNAL4 | 10126 | 204008_at | 0.0795 | 0.6669 | |
| GSE97050 | DNAL4 | 10126 | A_33_P3348625 | -0.2529 | 0.3113 | |
| SRP007169 | DNAL4 | 10126 | RNAseq | -0.9589 | 0.0223 | |
| SRP008496 | DNAL4 | 10126 | RNAseq | -0.6627 | 0.0233 | |
| SRP064894 | DNAL4 | 10126 | RNAseq | 0.3501 | 0.1947 | |
| SRP133303 | DNAL4 | 10126 | RNAseq | 0.0297 | 0.8963 | |
| SRP159526 | DNAL4 | 10126 | RNAseq | 0.6266 | 0.0270 | |
| SRP193095 | DNAL4 | 10126 | RNAseq | -0.1196 | 0.3665 | |
| SRP219564 | DNAL4 | 10126 | RNAseq | 0.2594 | 0.3704 | |
| TCGA | DNAL4 | 10126 | RNAseq | 0.1118 | 0.1144 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DNAL4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNAL4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNAL4 | 10126 | 6 | 5 | 19 | |
| GSE20123 | DNAL4 | 10126 | 6 | 4 | 20 | |
| GSE43470 | DNAL4 | 10126 | 5 | 5 | 33 | |
| GSE46452 | DNAL4 | 10126 | 32 | 2 | 25 | |
| GSE47630 | DNAL4 | 10126 | 9 | 4 | 27 | |
| GSE54993 | DNAL4 | 10126 | 3 | 6 | 61 | |
| GSE54994 | DNAL4 | 10126 | 9 | 7 | 37 | |
| GSE60625 | DNAL4 | 10126 | 5 | 0 | 6 | |
| GSE74703 | DNAL4 | 10126 | 5 | 4 | 27 | |
| GSE74704 | DNAL4 | 10126 | 3 | 2 | 15 | |
| TCGA | DNAL4 | 10126 | 27 | 15 | 54 |
Total number of gains: 110; Total number of losses: 54; Total Number of normals: 324.
Somatic mutations of DNAL4:
Generating mutation plots.
Highly correlated genes for DNAL4:
Showing top 20/93 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNAL4 | TMUB1 | 0.802373 | 3 | 0 | 3 |
| DNAL4 | ZSWIM3 | 0.791689 | 3 | 0 | 3 |
| DNAL4 | ABCA2 | 0.79049 | 3 | 0 | 3 |
| DNAL4 | POMT2 | 0.750034 | 4 | 0 | 4 |
| DNAL4 | PMPCA | 0.746312 | 3 | 0 | 3 |
| DNAL4 | PPP2R5D | 0.74523 | 3 | 0 | 3 |
| DNAL4 | CHMP6 | 0.739844 | 4 | 0 | 4 |
| DNAL4 | ITGA2B | 0.739654 | 3 | 0 | 3 |
| DNAL4 | POLL | 0.738242 | 3 | 0 | 3 |
| DNAL4 | TBC1D10B | 0.714625 | 4 | 0 | 4 |
| DNAL4 | RNF123 | 0.70987 | 3 | 0 | 3 |
| DNAL4 | HSD17B14 | 0.708197 | 3 | 0 | 3 |
| DNAL4 | TMEM102 | 0.703148 | 3 | 0 | 3 |
| DNAL4 | TFE3 | 0.702082 | 3 | 0 | 3 |
| DNAL4 | SLC27A5 | 0.699427 | 3 | 0 | 3 |
| DNAL4 | SCN9A | 0.695481 | 3 | 0 | 3 |
| DNAL4 | RUSC1 | 0.694238 | 3 | 0 | 3 |
| DNAL4 | ADCK5 | 0.690584 | 3 | 0 | 3 |
| DNAL4 | SLC6A13 | 0.687206 | 3 | 0 | 3 |
| DNAL4 | TRIM41 | 0.685738 | 3 | 0 | 3 |
For details and further investigation, click here
