| Full name: inorganic pyrophosphatase 2 | Alias Symbol: FLJ20459 | ||
| Type: protein-coding gene | Cytoband: 4q24 | ||
| Entrez ID: 27068 | HGNC ID: HGNC:28883 | Ensembl Gene: ENSG00000138777 | OMIM ID: 609988 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PPA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPA2 | 27068 | 220741_s_at | 0.0479 | 0.9291 | |
| GSE20347 | PPA2 | 27068 | 220741_s_at | -0.3509 | 0.0018 | |
| GSE23400 | PPA2 | 27068 | 220741_s_at | -0.2344 | 0.0019 | |
| GSE26886 | PPA2 | 27068 | 220741_s_at | 0.4390 | 0.0508 | |
| GSE29001 | PPA2 | 27068 | 220741_s_at | -0.6124 | 0.3196 | |
| GSE38129 | PPA2 | 27068 | 220741_s_at | -0.2609 | 0.0229 | |
| GSE45670 | PPA2 | 27068 | 220741_s_at | -0.2862 | 0.0444 | |
| GSE53622 | PPA2 | 27068 | 6161 | -0.0126 | 0.8529 | |
| GSE53624 | PPA2 | 27068 | 6161 | -0.1156 | 0.1597 | |
| GSE63941 | PPA2 | 27068 | 220741_s_at | 0.0471 | 0.9011 | |
| GSE77861 | PPA2 | 27068 | 220741_s_at | -0.7421 | 0.0496 | |
| GSE97050 | PPA2 | 27068 | A_33_P3219010 | 0.0703 | 0.8105 | |
| SRP007169 | PPA2 | 27068 | RNAseq | -0.8571 | 0.0429 | |
| SRP008496 | PPA2 | 27068 | RNAseq | -0.8254 | 0.0014 | |
| SRP064894 | PPA2 | 27068 | RNAseq | -0.3917 | 0.0376 | |
| SRP133303 | PPA2 | 27068 | RNAseq | 0.0511 | 0.7891 | |
| SRP159526 | PPA2 | 27068 | RNAseq | -0.5411 | 0.0381 | |
| SRP193095 | PPA2 | 27068 | RNAseq | -0.8361 | 0.0000 | |
| SRP219564 | PPA2 | 27068 | RNAseq | -0.6060 | 0.0100 | |
| TCGA | PPA2 | 27068 | RNAseq | -0.1410 | 0.0039 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPA2 | 27068 | 0 | 12 | 18 | |
| GSE20123 | PPA2 | 27068 | 0 | 12 | 18 | |
| GSE43470 | PPA2 | 27068 | 0 | 13 | 30 | |
| GSE46452 | PPA2 | 27068 | 1 | 36 | 22 | |
| GSE47630 | PPA2 | 27068 | 0 | 20 | 20 | |
| GSE54993 | PPA2 | 27068 | 9 | 0 | 61 | |
| GSE54994 | PPA2 | 27068 | 1 | 10 | 42 | |
| GSE60625 | PPA2 | 27068 | 0 | 3 | 8 | |
| GSE74703 | PPA2 | 27068 | 0 | 11 | 25 | |
| GSE74704 | PPA2 | 27068 | 0 | 6 | 14 | |
| TCGA | PPA2 | 27068 | 7 | 39 | 50 |
Total number of gains: 18; Total number of losses: 162; Total Number of normals: 308.
Somatic mutations of PPA2:
Generating mutation plots.
Highly correlated genes for PPA2:
Showing top 20/107 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPA2 | MAFA | 0.815166 | 3 | 0 | 3 |
| PPA2 | SPN | 0.732552 | 4 | 0 | 3 |
| PPA2 | GPN2 | 0.730169 | 3 | 0 | 3 |
| PPA2 | RMDN1 | 0.714514 | 4 | 0 | 4 |
| PPA2 | CELF5 | 0.712058 | 3 | 0 | 3 |
| PPA2 | ZNRF2 | 0.706112 | 3 | 0 | 3 |
| PPA2 | ZBTB3 | 0.700523 | 3 | 0 | 3 |
| PPA2 | SLC37A1 | 0.697157 | 4 | 0 | 4 |
| PPA2 | YY2 | 0.688652 | 3 | 0 | 3 |
| PPA2 | ZNF682 | 0.685348 | 6 | 0 | 5 |
| PPA2 | KLRG2 | 0.682229 | 3 | 0 | 3 |
| PPA2 | C1QL2 | 0.678255 | 3 | 0 | 3 |
| PPA2 | ARHGAP30 | 0.669815 | 3 | 0 | 3 |
| PPA2 | OR2C3 | 0.668891 | 4 | 0 | 3 |
| PPA2 | ZNF329 | 0.668464 | 4 | 0 | 4 |
| PPA2 | RNF180 | 0.668087 | 3 | 0 | 3 |
| PPA2 | BCKDHA | 0.663584 | 4 | 0 | 4 |
| PPA2 | FAAH2 | 0.651543 | 3 | 0 | 3 |
| PPA2 | LBX2 | 0.648707 | 3 | 0 | 3 |
| PPA2 | ZNF738 | 0.636721 | 4 | 0 | 3 |
For details and further investigation, click here
