| Full name: PTPRF interacting protein alpha 3 | Alias Symbol: KIAA0654|LPNA3|MGC126567|MGC126569 | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 8541 | HGNC ID: HGNC:9247 | Ensembl Gene: ENSG00000177380 | OMIM ID: 603144 |
| Drug and gene relationship at DGIdb | |||
Expression of PPFIA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPFIA3 | 8541 | 213368_x_at | 0.4202 | 0.2886 | |
| GSE20347 | PPFIA3 | 8541 | 213368_x_at | -0.0547 | 0.5466 | |
| GSE23400 | PPFIA3 | 8541 | 213368_x_at | -0.0463 | 0.2365 | |
| GSE26886 | PPFIA3 | 8541 | 215280_s_at | -0.3954 | 0.0086 | |
| GSE29001 | PPFIA3 | 8541 | 215280_s_at | -0.1012 | 0.8677 | |
| GSE38129 | PPFIA3 | 8541 | 213368_x_at | 0.1003 | 0.3531 | |
| GSE45670 | PPFIA3 | 8541 | 213368_x_at | 0.0394 | 0.7525 | |
| GSE53622 | PPFIA3 | 8541 | 18372 | 0.9579 | 0.0000 | |
| GSE53624 | PPFIA3 | 8541 | 18372 | 1.4020 | 0.0000 | |
| GSE63941 | PPFIA3 | 8541 | 213368_x_at | 0.1894 | 0.4152 | |
| GSE77861 | PPFIA3 | 8541 | 213368_x_at | 0.1543 | 0.4111 | |
| GSE97050 | PPFIA3 | 8541 | A_23_P320553 | -0.0223 | 0.9259 | |
| SRP007169 | PPFIA3 | 8541 | RNAseq | 0.3233 | 0.6630 | |
| SRP064894 | PPFIA3 | 8541 | RNAseq | 0.4719 | 0.0941 | |
| SRP133303 | PPFIA3 | 8541 | RNAseq | -0.4418 | 0.1190 | |
| SRP159526 | PPFIA3 | 8541 | RNAseq | 0.0547 | 0.8610 | |
| SRP193095 | PPFIA3 | 8541 | RNAseq | 0.0455 | 0.7952 | |
| SRP219564 | PPFIA3 | 8541 | RNAseq | -0.4061 | 0.2813 | |
| TCGA | PPFIA3 | 8541 | RNAseq | 0.4873 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PPFIA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPFIA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPFIA3 | 8541 | 4 | 4 | 22 | |
| GSE20123 | PPFIA3 | 8541 | 4 | 3 | 23 | |
| GSE43470 | PPFIA3 | 8541 | 4 | 10 | 29 | |
| GSE46452 | PPFIA3 | 8541 | 45 | 1 | 13 | |
| GSE47630 | PPFIA3 | 8541 | 10 | 6 | 24 | |
| GSE54993 | PPFIA3 | 8541 | 17 | 4 | 49 | |
| GSE54994 | PPFIA3 | 8541 | 4 | 14 | 35 | |
| GSE60625 | PPFIA3 | 8541 | 9 | 0 | 2 | |
| GSE74703 | PPFIA3 | 8541 | 4 | 7 | 25 | |
| GSE74704 | PPFIA3 | 8541 | 4 | 1 | 15 | |
| TCGA | PPFIA3 | 8541 | 14 | 18 | 64 |
Total number of gains: 119; Total number of losses: 68; Total Number of normals: 301.
Somatic mutations of PPFIA3:
Generating mutation plots.
Highly correlated genes for PPFIA3:
Showing top 20/106 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPFIA3 | BCAP31 | 0.720778 | 3 | 0 | 3 |
| PPFIA3 | ZNF385C | 0.697281 | 3 | 0 | 3 |
| PPFIA3 | UBALD1 | 0.660773 | 3 | 0 | 3 |
| PPFIA3 | LAS1L | 0.657229 | 3 | 0 | 3 |
| PPFIA3 | KLHDC4 | 0.65378 | 3 | 0 | 3 |
| PPFIA3 | C6orf47 | 0.640904 | 4 | 0 | 3 |
| PPFIA3 | FASN | 0.638555 | 4 | 0 | 3 |
| PPFIA3 | G6PD | 0.638184 | 4 | 0 | 3 |
| PPFIA3 | MICALL1 | 0.630837 | 4 | 0 | 3 |
| PPFIA3 | ZC3H8 | 0.620068 | 4 | 0 | 3 |
| PPFIA3 | ZNF316 | 0.619211 | 4 | 0 | 3 |
| PPFIA3 | HIP1R | 0.61402 | 4 | 0 | 3 |
| PPFIA3 | ANO9 | 0.613539 | 3 | 0 | 3 |
| PPFIA3 | GNG4 | 0.612077 | 5 | 0 | 3 |
| PPFIA3 | FAAH | 0.610901 | 4 | 0 | 3 |
| PPFIA3 | CDC42BPB | 0.609619 | 6 | 0 | 5 |
| PPFIA3 | STK11 | 0.606489 | 4 | 0 | 4 |
| PPFIA3 | RBM42 | 0.60231 | 5 | 0 | 4 |
| PPFIA3 | HCN3 | 0.59841 | 5 | 0 | 4 |
| PPFIA3 | CHMP6 | 0.596025 | 3 | 0 | 3 |
For details and further investigation, click here
