| Full name: fatty acid synthase | Alias Symbol: FAS|SDR27X1 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 2194 | HGNC ID: HGNC:3594 | Ensembl Gene: ENSG00000169710 | OMIM ID: 600212 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FASN involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway | |
| hsa04910 | Insulin signaling pathway |
Expression of FASN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FASN | 2194 | 212218_s_at | 1.4221 | 0.0983 | |
| GSE20347 | FASN | 2194 | 212218_s_at | 0.2003 | 0.2035 | |
| GSE23400 | FASN | 2194 | 212218_s_at | 0.1820 | 0.0607 | |
| GSE26886 | FASN | 2194 | 212218_s_at | 0.1991 | 0.2781 | |
| GSE29001 | FASN | 2194 | 212218_s_at | 0.0403 | 0.8330 | |
| GSE38129 | FASN | 2194 | 212218_s_at | 0.4068 | 0.0129 | |
| GSE45670 | FASN | 2194 | 212218_s_at | 0.2784 | 0.0837 | |
| GSE53622 | FASN | 2194 | 5996 | 0.1101 | 0.2674 | |
| GSE53624 | FASN | 2194 | 5996 | 0.2265 | 0.0007 | |
| GSE63941 | FASN | 2194 | 212218_s_at | 1.3171 | 0.0159 | |
| GSE77861 | FASN | 2194 | 212218_s_at | 0.0454 | 0.8848 | |
| GSE97050 | FASN | 2194 | A_33_P3329344 | 0.3795 | 0.2232 | |
| SRP007169 | FASN | 2194 | RNAseq | 0.6697 | 0.0835 | |
| SRP008496 | FASN | 2194 | RNAseq | -0.0374 | 0.9114 | |
| SRP064894 | FASN | 2194 | RNAseq | -0.2828 | 0.2774 | |
| SRP133303 | FASN | 2194 | RNAseq | 0.0065 | 0.9757 | |
| SRP159526 | FASN | 2194 | RNAseq | 0.6931 | 0.0412 | |
| SRP193095 | FASN | 2194 | RNAseq | 0.1421 | 0.3570 | |
| SRP219564 | FASN | 2194 | RNAseq | 0.5392 | 0.3024 | |
| TCGA | FASN | 2194 | RNAseq | 0.0188 | 0.7184 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by FASN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FASN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FASN | 2194 | 4 | 4 | 22 | |
| GSE20123 | FASN | 2194 | 4 | 4 | 22 | |
| GSE43470 | FASN | 2194 | 3 | 5 | 35 | |
| GSE46452 | FASN | 2194 | 34 | 0 | 25 | |
| GSE47630 | FASN | 2194 | 9 | 2 | 29 | |
| GSE54993 | FASN | 2194 | 2 | 5 | 63 | |
| GSE54994 | FASN | 2194 | 10 | 6 | 37 | |
| GSE60625 | FASN | 2194 | 6 | 0 | 5 | |
| GSE74703 | FASN | 2194 | 3 | 3 | 30 | |
| GSE74704 | FASN | 2194 | 4 | 3 | 13 | |
| TCGA | FASN | 2194 | 24 | 13 | 59 |
Total number of gains: 103; Total number of losses: 45; Total Number of normals: 340.
Somatic mutations of FASN:
Generating mutation plots.
Highly correlated genes for FASN:
Showing top 20/725 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FASN | SDF4 | 0.788796 | 3 | 0 | 3 |
| FASN | RNF2 | 0.779942 | 3 | 0 | 3 |
| FASN | PACS1 | 0.771632 | 3 | 0 | 3 |
| FASN | DUSP23 | 0.770848 | 3 | 0 | 3 |
| FASN | TRAPPC10 | 0.748738 | 3 | 0 | 3 |
| FASN | C21orf58 | 0.748027 | 3 | 0 | 3 |
| FASN | OCIAD2 | 0.743145 | 3 | 0 | 3 |
| FASN | UBR4 | 0.738362 | 3 | 0 | 3 |
| FASN | RAD18 | 0.736015 | 3 | 0 | 3 |
| FASN | DIAPH1 | 0.731976 | 3 | 0 | 3 |
| FASN | TCEANC2 | 0.718614 | 3 | 0 | 3 |
| FASN | ARL6IP1 | 0.714758 | 4 | 0 | 4 |
| FASN | GPATCH4 | 0.707452 | 3 | 0 | 3 |
| FASN | ZBTB37 | 0.704913 | 3 | 0 | 3 |
| FASN | BRIX1 | 0.704102 | 4 | 0 | 3 |
| FASN | SLC39A7 | 0.69958 | 3 | 0 | 3 |
| FASN | CDK18 | 0.695838 | 5 | 0 | 4 |
| FASN | AAK1 | 0.694641 | 4 | 0 | 3 |
| FASN | CD22 | 0.687324 | 3 | 0 | 3 |
| FASN | AGPAT3 | 0.685594 | 3 | 0 | 3 |
For details and further investigation, click here
