| Full name: kelch domain containing 4 | Alias Symbol: DKFZp434G0522 | ||
| Type: protein-coding gene | Cytoband: 16q24.2 | ||
| Entrez ID: 54758 | HGNC ID: HGNC:25272 | Ensembl Gene: ENSG00000104731 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of KLHDC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHDC4 | 54758 | 221219_s_at | 0.3964 | 0.4120 | |
| GSE20347 | KLHDC4 | 54758 | 221219_s_at | -0.0114 | 0.9422 | |
| GSE23400 | KLHDC4 | 54758 | 221219_s_at | -0.0843 | 0.0623 | |
| GSE26886 | KLHDC4 | 54758 | 221219_s_at | -0.3468 | 0.2225 | |
| GSE29001 | KLHDC4 | 54758 | 221219_s_at | -0.0655 | 0.8408 | |
| GSE38129 | KLHDC4 | 54758 | 221219_s_at | 0.0272 | 0.8379 | |
| GSE45670 | KLHDC4 | 54758 | 221219_s_at | 0.1056 | 0.4385 | |
| GSE53622 | KLHDC4 | 54758 | 6556 | 0.1553 | 0.0414 | |
| GSE53624 | KLHDC4 | 54758 | 6556 | 0.2561 | 0.0332 | |
| GSE63941 | KLHDC4 | 54758 | 221219_s_at | 0.2115 | 0.6418 | |
| GSE77861 | KLHDC4 | 54758 | 229035_s_at | 0.0728 | 0.6162 | |
| GSE97050 | KLHDC4 | 54758 | A_33_P3375476 | 0.3413 | 0.1736 | |
| SRP064894 | KLHDC4 | 54758 | RNAseq | 0.3757 | 0.1242 | |
| SRP133303 | KLHDC4 | 54758 | RNAseq | 0.3953 | 0.1068 | |
| SRP159526 | KLHDC4 | 54758 | RNAseq | 0.2466 | 0.4028 | |
| SRP193095 | KLHDC4 | 54758 | RNAseq | 0.4466 | 0.0017 | |
| TCGA | KLHDC4 | 54758 | RNAseq | -0.0500 | 0.4494 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KLHDC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHDC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHDC4 | 54758 | 4 | 3 | 23 | |
| GSE20123 | KLHDC4 | 54758 | 4 | 3 | 23 | |
| GSE43470 | KLHDC4 | 54758 | 1 | 13 | 29 | |
| GSE46452 | KLHDC4 | 54758 | 38 | 1 | 20 | |
| GSE47630 | KLHDC4 | 54758 | 11 | 9 | 20 | |
| GSE54993 | KLHDC4 | 54758 | 3 | 4 | 63 | |
| GSE54994 | KLHDC4 | 54758 | 9 | 11 | 33 | |
| GSE60625 | KLHDC4 | 54758 | 4 | 0 | 7 | |
| GSE74703 | KLHDC4 | 54758 | 1 | 9 | 26 | |
| GSE74704 | KLHDC4 | 54758 | 3 | 2 | 15 | |
| TCGA | KLHDC4 | 54758 | 28 | 15 | 53 |
Total number of gains: 106; Total number of losses: 70; Total Number of normals: 312.
Somatic mutations of KLHDC4:
Generating mutation plots.
Highly correlated genes for KLHDC4:
Showing top 20/146 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHDC4 | RTN4RL1 | 0.81057 | 3 | 0 | 3 |
| KLHDC4 | TDRD9 | 0.72751 | 3 | 0 | 3 |
| KLHDC4 | CYP11B1 | 0.721715 | 3 | 0 | 3 |
| KLHDC4 | IL1F10 | 0.707364 | 3 | 0 | 3 |
| KLHDC4 | CSH2 | 0.704031 | 3 | 0 | 3 |
| KLHDC4 | PLXNA3 | 0.694187 | 4 | 0 | 3 |
| KLHDC4 | SLC22A31 | 0.684472 | 3 | 0 | 3 |
| KLHDC4 | KIFC2 | 0.680164 | 5 | 0 | 4 |
| KLHDC4 | SHANK1 | 0.67739 | 3 | 0 | 3 |
| KLHDC4 | CEMP1 | 0.675227 | 3 | 0 | 3 |
| KLHDC4 | GCM2 | 0.672668 | 5 | 0 | 5 |
| KLHDC4 | KIF21B | 0.671939 | 4 | 0 | 4 |
| KLHDC4 | CDC42EP2 | 0.666606 | 3 | 0 | 3 |
| KLHDC4 | HAUS5 | 0.66569 | 3 | 0 | 3 |
| KLHDC4 | IPO13 | 0.663116 | 3 | 0 | 3 |
| KLHDC4 | DFFB | 0.661773 | 3 | 0 | 3 |
| KLHDC4 | CC2D1B | 0.656609 | 4 | 0 | 3 |
| KLHDC4 | PPFIA3 | 0.65378 | 3 | 0 | 3 |
| KLHDC4 | WDR64 | 0.650702 | 3 | 0 | 3 |
| KLHDC4 | GFRA4 | 0.649648 | 3 | 0 | 3 |
For details and further investigation, click here
