GNG4

 

Full name: G protein subunit gamma 4 Alias Symbol: 
Type: protein-coding gene Cytoband: 1q42.3
Entrez ID: 2786 HGNC ID: HGNC:4407 Ensembl Gene: ENSG00000168243 OMIM ID: 604388
Drug and gene relationship at DGIdb

 

GNG4 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNG4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNG4 2786 205184_at -0.2413 0.7692
GSE20347 GNG4 2786 205184_at -0.1184 0.6907
GSE23400 GNG4 2786 205184_at -0.2644 0.0001
GSE26886 GNG4 2786 205184_at -1.2114 0.0069
GSE29001 GNG4 2786 205184_at -0.5489 0.3127
GSE38129 GNG4 2786 205184_at 0.0330 0.9242
GSE45670 GNG4 2786 205184_at -0.3144 0.5245
GSE53622 GNG4 2786 44405 -0.2607 0.2931
GSE53624 GNG4 2786 44405 -0.4808 0.0062
GSE63941 GNG4 2786 205184_at 2.7602 0.0142
GSE77861 GNG4 2786 205184_at 0.1238 0.8031
GSE97050 GNG4 2786 A_33_P3301709 -0.0902 0.7683
SRP007169 GNG4 2786 RNAseq -1.2559 0.0879
SRP064894 GNG4 2786 RNAseq -0.8991 0.0575
SRP133303 GNG4 2786 RNAseq -0.8714 0.0000
SRP159526 GNG4 2786 RNAseq 0.1223 0.8581
SRP193095 GNG4 2786 RNAseq -0.3847 0.1275
SRP219564 GNG4 2786 RNAseq -0.2134 0.7831
TCGA GNG4 2786 RNAseq 0.4626 0.0763

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by GNG4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNG4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNG4 2786 10 0 20
GSE20123 GNG4 2786 11 0 19
GSE43470 GNG4 2786 8 1 34
GSE46452 GNG4 2786 4 2 53
GSE47630 GNG4 2786 15 0 25
GSE54993 GNG4 2786 0 6 64
GSE54994 GNG4 2786 16 0 37
GSE60625 GNG4 2786 0 0 11
GSE74703 GNG4 2786 8 1 27
GSE74704 GNG4 2786 5 0 15
TCGA GNG4 2786 43 4 49

Total number of gains: 120; Total number of losses: 14; Total Number of normals: 354.  

 

Somatic mutations of GNG4:

 

Generating mutation plots.

 

Highly correlated genes for GNG4:

 

Showing top 20/106 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNG4FOXN10.702751303
GNG4EML50.683313303
GNG4MAL20.673125303
GNG4FOLR30.653361303
GNG4STX190.64877403
GNG4VSIG10L0.62078403
GNG4CBR30.617214403
GNG4PPFIA30.612077503
GNG4EAF10.611804303
GNG4TMEM1540.607314403
GNG4NBEAL20.605835604
GNG4UCA10.60377403
GNG4KRT6B0.603759403
GNG4PNP0.602409303
GNG4LPAR50.600716403
GNG4TUBA4A0.599638403
GNG4CNFN0.599042505
GNG4ARHGEF370.598254303
GNG4C6orf1320.597722403
GNG4GIPC10.591518503

For details and further investigation, click here