| Full name: makorin ring finger protein 3 | Alias Symbol: RNF63|ZFP127|MGC88288 | ||
| Type: protein-coding gene | Cytoband: 15q11.2 | ||
| Entrez ID: 7681 | HGNC ID: HGNC:7114 | Ensembl Gene: ENSG00000179455 | OMIM ID: 603856 |
| Drug and gene relationship at DGIdb | |||
Expression of MKRN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MKRN3 | 7681 | 206585_at | 0.0551 | 0.8132 | |
| GSE20347 | MKRN3 | 7681 | 206585_at | -0.0025 | 0.9700 | |
| GSE23400 | MKRN3 | 7681 | 206585_at | -0.0306 | 0.1498 | |
| GSE26886 | MKRN3 | 7681 | 206585_at | 0.0920 | 0.3049 | |
| GSE29001 | MKRN3 | 7681 | 206585_at | 0.1176 | 0.5545 | |
| GSE38129 | MKRN3 | 7681 | 206585_at | 0.0813 | 0.1568 | |
| GSE45670 | MKRN3 | 7681 | 206585_at | 0.0537 | 0.5766 | |
| GSE53622 | MKRN3 | 7681 | 17233 | 0.9545 | 0.0002 | |
| GSE53624 | MKRN3 | 7681 | 17233 | 0.6455 | 0.0007 | |
| GSE63941 | MKRN3 | 7681 | 206585_at | 0.1619 | 0.3066 | |
| GSE77861 | MKRN3 | 7681 | 206585_at | -0.1144 | 0.3975 | |
| SRP007169 | MKRN3 | 7681 | RNAseq | 1.1667 | 0.0672 | |
| SRP064894 | MKRN3 | 7681 | RNAseq | 0.6005 | 0.1958 | |
| SRP133303 | MKRN3 | 7681 | RNAseq | 0.3067 | 0.5821 | |
| SRP159526 | MKRN3 | 7681 | RNAseq | 0.9842 | 0.0386 | |
| SRP219564 | MKRN3 | 7681 | RNAseq | 0.6138 | 0.4579 | |
| TCGA | MKRN3 | 7681 | RNAseq | 1.9577 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MKRN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MKRN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MKRN3 | 7681 | 3 | 5 | 22 | |
| GSE20123 | MKRN3 | 7681 | 2 | 5 | 23 | |
| GSE43470 | MKRN3 | 7681 | 3 | 5 | 35 | |
| GSE46452 | MKRN3 | 7681 | 3 | 7 | 49 | |
| GSE47630 | MKRN3 | 7681 | 8 | 11 | 21 | |
| GSE54993 | MKRN3 | 7681 | 4 | 6 | 60 | |
| GSE54994 | MKRN3 | 7681 | 7 | 6 | 40 | |
| GSE60625 | MKRN3 | 7681 | 4 | 3 | 4 | |
| GSE74703 | MKRN3 | 7681 | 3 | 3 | 30 | |
| GSE74704 | MKRN3 | 7681 | 1 | 5 | 14 | |
| TCGA | MKRN3 | 7681 | 17 | 20 | 59 |
Total number of gains: 55; Total number of losses: 76; Total Number of normals: 357.
Somatic mutations of MKRN3:
Generating mutation plots.
Highly correlated genes for MKRN3:
Showing top 20/84 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MKRN3 | SLC30A3 | 0.694849 | 3 | 0 | 3 |
| MKRN3 | PKLR | 0.685845 | 3 | 0 | 3 |
| MKRN3 | PPM1E | 0.65627 | 3 | 0 | 3 |
| MKRN3 | ADAM21 | 0.654041 | 3 | 0 | 3 |
| MKRN3 | TAS2R13 | 0.649252 | 3 | 0 | 3 |
| MKRN3 | CACNB1 | 0.636117 | 3 | 0 | 3 |
| MKRN3 | BRDT | 0.634241 | 4 | 0 | 3 |
| MKRN3 | C9orf116 | 0.619284 | 3 | 0 | 3 |
| MKRN3 | ZNF8 | 0.615216 | 3 | 0 | 3 |
| MKRN3 | GRIN1 | 0.612764 | 3 | 0 | 3 |
| MKRN3 | IFNA16 | 0.611138 | 3 | 0 | 3 |
| MKRN3 | ENTPD2 | 0.610204 | 3 | 0 | 3 |
| MKRN3 | FANCA | 0.604802 | 4 | 0 | 4 |
| MKRN3 | BIRC7 | 0.603547 | 3 | 0 | 3 |
| MKRN3 | TOP3A | 0.602389 | 6 | 0 | 4 |
| MKRN3 | HEXA-AS1 | 0.598208 | 3 | 0 | 3 |
| MKRN3 | MSI1 | 0.591197 | 3 | 0 | 3 |
| MKRN3 | GPLD1 | 0.587431 | 4 | 0 | 3 |
| MKRN3 | CDH18 | 0.583055 | 3 | 0 | 3 |
| MKRN3 | GPR45 | 0.580383 | 3 | 0 | 3 |
For details and further investigation, click here
