| Full name: Zic family member 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q24 | ||
| Entrez ID: 84107 | HGNC ID: HGNC:20393 | Ensembl Gene: ENSG00000174963 | OMIM ID: 608948 |
| Drug and gene relationship at DGIdb | |||
Expression of ZIC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZIC4 | 84107 | 211463_at | 0.0673 | 0.7661 | |
| GSE20347 | ZIC4 | 84107 | 211463_at | -0.0230 | 0.7573 | |
| GSE23400 | ZIC4 | 84107 | 211463_at | -0.0484 | 0.0531 | |
| GSE26886 | ZIC4 | 84107 | 211463_at | 0.3043 | 0.0045 | |
| GSE29001 | ZIC4 | 84107 | 211463_at | -0.0383 | 0.8197 | |
| GSE38129 | ZIC4 | 84107 | 211463_at | -0.0548 | 0.4084 | |
| GSE45670 | ZIC4 | 84107 | 211463_at | 0.0196 | 0.8392 | |
| GSE53622 | ZIC4 | 84107 | 105152 | 0.9743 | 0.0000 | |
| GSE53624 | ZIC4 | 84107 | 158789 | 0.6764 | 0.0000 | |
| GSE63941 | ZIC4 | 84107 | 211463_at | 0.0883 | 0.5650 | |
| GSE77861 | ZIC4 | 84107 | 211463_at | -0.0654 | 0.4728 | |
| TCGA | ZIC4 | 84107 | RNAseq | 2.4263 | 0.0044 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ZIC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZIC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZIC4 | 84107 | 22 | 0 | 8 | |
| GSE20123 | ZIC4 | 84107 | 22 | 0 | 8 | |
| GSE43470 | ZIC4 | 84107 | 23 | 0 | 20 | |
| GSE46452 | ZIC4 | 84107 | 16 | 3 | 40 | |
| GSE47630 | ZIC4 | 84107 | 19 | 3 | 18 | |
| GSE54993 | ZIC4 | 84107 | 1 | 9 | 60 | |
| GSE54994 | ZIC4 | 84107 | 34 | 1 | 18 | |
| GSE60625 | ZIC4 | 84107 | 0 | 6 | 5 | |
| GSE74703 | ZIC4 | 84107 | 20 | 0 | 16 | |
| GSE74704 | ZIC4 | 84107 | 15 | 0 | 5 | |
| TCGA | ZIC4 | 84107 | 68 | 2 | 26 |
Total number of gains: 240; Total number of losses: 24; Total Number of normals: 224.
Somatic mutations of ZIC4:
Generating mutation plots.
Highly correlated genes for ZIC4:
Showing top 20/326 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZIC4 | FOXN3-AS2 | 0.715256 | 4 | 0 | 4 |
| ZIC4 | DMC1 | 0.688722 | 3 | 0 | 3 |
| ZIC4 | IFNA4 | 0.684609 | 4 | 0 | 4 |
| ZIC4 | ZP2 | 0.666569 | 3 | 0 | 3 |
| ZIC4 | PPM1E | 0.665675 | 3 | 0 | 3 |
| ZIC4 | NEU3 | 0.661332 | 6 | 0 | 6 |
| ZIC4 | ZMAT4 | 0.65853 | 4 | 0 | 4 |
| ZIC4 | GPR22 | 0.646001 | 4 | 0 | 4 |
| ZIC4 | KCNB2 | 0.641618 | 3 | 0 | 3 |
| ZIC4 | GML | 0.640802 | 5 | 0 | 4 |
| ZIC4 | GPR21 | 0.640562 | 5 | 0 | 5 |
| ZIC4 | MYL1 | 0.638321 | 5 | 0 | 4 |
| ZIC4 | RALYL | 0.637252 | 4 | 0 | 3 |
| ZIC4 | SPICE1 | 0.637178 | 3 | 0 | 3 |
| ZIC4 | CRISP1 | 0.636001 | 5 | 0 | 4 |
| ZIC4 | HHLA1 | 0.635567 | 4 | 0 | 4 |
| ZIC4 | ADAM22 | 0.63234 | 4 | 0 | 3 |
| ZIC4 | OR2H2 | 0.626237 | 4 | 0 | 3 |
| ZIC4 | C8A | 0.623783 | 5 | 0 | 5 |
| ZIC4 | CD80 | 0.623743 | 4 | 0 | 3 |
For details and further investigation, click here
