| Full name: glutamate metabotropic receptor 7 | Alias Symbol: GLUR7|GPRC1G|mGlu7|MGLUR7|PPP1R87 | ||
| Type: protein-coding gene | Cytoband: 3p26.1 | ||
| Entrez ID: 2917 | HGNC ID: HGNC:4599 | Ensembl Gene: ENSG00000196277 | OMIM ID: 604101 |
| Drug and gene relationship at DGIdb | |||
GRM7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04724 | Glutamatergic synapse |
Expression of GRM7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRM7 | 2917 | 217008_s_at | -0.0470 | 0.8656 | |
| GSE20347 | GRM7 | 2917 | 217008_s_at | -0.0052 | 0.9541 | |
| GSE23400 | GRM7 | 2917 | 217008_s_at | -0.1236 | 0.0003 | |
| GSE26886 | GRM7 | 2917 | 217008_s_at | 0.2220 | 0.0349 | |
| GSE29001 | GRM7 | 2917 | 207548_at | 0.0774 | 0.5815 | |
| GSE38129 | GRM7 | 2917 | 217008_s_at | -0.0402 | 0.6076 | |
| GSE53622 | GRM7 | 2917 | 12437 | -0.1217 | 0.3197 | |
| GSE53624 | GRM7 | 2917 | 3753 | 0.1085 | 0.2240 | |
| GSE63941 | GRM7 | 2917 | 217008_s_at | 0.0754 | 0.5513 | |
| GSE77861 | GRM7 | 2917 | 217008_s_at | -0.0920 | 0.3282 | |
| TCGA | GRM7 | 2917 | RNAseq | -1.0277 | 0.2371 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GRM7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRM7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRM7 | 2917 | 1 | 18 | 11 | |
| GSE20123 | GRM7 | 2917 | 1 | 18 | 11 | |
| GSE43470 | GRM7 | 2917 | 0 | 21 | 22 | |
| GSE46452 | GRM7 | 2917 | 2 | 17 | 40 | |
| GSE47630 | GRM7 | 2917 | 1 | 23 | 16 | |
| GSE54993 | GRM7 | 2917 | 6 | 1 | 63 | |
| GSE54994 | GRM7 | 2917 | 2 | 32 | 19 | |
| GSE60625 | GRM7 | 2917 | 5 | 0 | 6 | |
| GSE74703 | GRM7 | 2917 | 0 | 18 | 18 | |
| GSE74704 | GRM7 | 2917 | 1 | 11 | 8 | |
| TCGA | GRM7 | 2917 | 2 | 67 | 27 |
Total number of gains: 21; Total number of losses: 226; Total Number of normals: 241.
Somatic mutations of GRM7:
Generating mutation plots.
Highly correlated genes for GRM7:
Showing top 20/576 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRM7 | DPPA4 | 0.7213 | 3 | 0 | 3 |
| GRM7 | MPZ | 0.71184 | 3 | 0 | 3 |
| GRM7 | SMIM6 | 0.698956 | 3 | 0 | 3 |
| GRM7 | HRG | 0.681953 | 3 | 0 | 3 |
| GRM7 | NRP2 | 0.67902 | 3 | 0 | 3 |
| GRM7 | LINC00028 | 0.67894 | 3 | 0 | 3 |
| GRM7 | KRT38 | 0.674751 | 3 | 0 | 3 |
| GRM7 | NMNAT2 | 0.67088 | 4 | 0 | 4 |
| GRM7 | C9orf131 | 0.666564 | 3 | 0 | 3 |
| GRM7 | LRRC75B | 0.657967 | 3 | 0 | 3 |
| GRM7 | EPX | 0.657891 | 4 | 0 | 4 |
| GRM7 | FBXO24 | 0.656161 | 3 | 0 | 3 |
| GRM7 | SCGB1D1 | 0.653451 | 3 | 0 | 3 |
| GRM7 | FKBP6 | 0.651215 | 4 | 0 | 3 |
| GRM7 | PRODH2 | 0.649767 | 4 | 0 | 4 |
| GRM7 | LGR5 | 0.649681 | 4 | 0 | 4 |
| GRM7 | PPM1E | 0.648912 | 5 | 0 | 4 |
| GRM7 | SARDH | 0.645714 | 4 | 0 | 4 |
| GRM7 | GIP | 0.64365 | 4 | 0 | 4 |
| GRM7 | TAS2R1 | 0.643127 | 5 | 0 | 4 |
For details and further investigation, click here
