| Full name: protoporphyrinogen oxidase | Alias Symbol: PPO | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 5498 | HGNC ID: HGNC:9280 | Ensembl Gene: ENSG00000143224 | OMIM ID: 600923 |
| Drug and gene relationship at DGIdb | |||
Expression of PPOX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPOX | 5498 | 204788_s_at | -0.1957 | 0.7059 | |
| GSE20347 | PPOX | 5498 | 204788_s_at | -0.2924 | 0.0054 | |
| GSE23400 | PPOX | 5498 | 204788_s_at | -0.2123 | 0.0001 | |
| GSE26886 | PPOX | 5498 | 204788_s_at | 0.3173 | 0.1800 | |
| GSE29001 | PPOX | 5498 | 204788_s_at | -0.2823 | 0.2780 | |
| GSE38129 | PPOX | 5498 | 204788_s_at | -0.1554 | 0.1650 | |
| GSE45670 | PPOX | 5498 | 204788_s_at | -0.3160 | 0.0140 | |
| GSE53622 | PPOX | 5498 | 13247 | -0.5985 | 0.0000 | |
| GSE53624 | PPOX | 5498 | 13247 | -0.3368 | 0.0000 | |
| GSE63941 | PPOX | 5498 | 204788_s_at | 0.1244 | 0.6897 | |
| GSE77861 | PPOX | 5498 | 204788_s_at | -0.2020 | 0.1371 | |
| GSE97050 | PPOX | 5498 | A_23_P201400 | -0.0231 | 0.9263 | |
| SRP007169 | PPOX | 5498 | RNAseq | -1.7599 | 0.0001 | |
| SRP008496 | PPOX | 5498 | RNAseq | -1.3028 | 0.0001 | |
| SRP064894 | PPOX | 5498 | RNAseq | -0.1718 | 0.4166 | |
| SRP133303 | PPOX | 5498 | RNAseq | -0.8024 | 0.0000 | |
| SRP159526 | PPOX | 5498 | RNAseq | 0.4225 | 0.3323 | |
| SRP193095 | PPOX | 5498 | RNAseq | -0.1677 | 0.2044 | |
| SRP219564 | PPOX | 5498 | RNAseq | 0.1021 | 0.8136 | |
| TCGA | PPOX | 5498 | RNAseq | -0.0172 | 0.8271 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PPOX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPOX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPOX | 5498 | 10 | 0 | 20 | |
| GSE20123 | PPOX | 5498 | 10 | 0 | 20 | |
| GSE43470 | PPOX | 5498 | 7 | 2 | 34 | |
| GSE46452 | PPOX | 5498 | 2 | 1 | 56 | |
| GSE47630 | PPOX | 5498 | 14 | 0 | 26 | |
| GSE54993 | PPOX | 5498 | 0 | 6 | 64 | |
| GSE54994 | PPOX | 5498 | 16 | 0 | 37 | |
| GSE60625 | PPOX | 5498 | 0 | 0 | 11 | |
| GSE74703 | PPOX | 5498 | 7 | 2 | 27 | |
| GSE74704 | PPOX | 5498 | 4 | 0 | 16 | |
| TCGA | PPOX | 5498 | 45 | 3 | 48 |
Total number of gains: 115; Total number of losses: 14; Total Number of normals: 359.
Somatic mutations of PPOX:
Generating mutation plots.
Highly correlated genes for PPOX:
Showing top 20/82 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPOX | TKTL1 | 0.727141 | 4 | 0 | 3 |
| PPOX | CCDC157 | 0.719773 | 3 | 0 | 3 |
| PPOX | SV2B | 0.708158 | 3 | 0 | 3 |
| PPOX | SLC23A3 | 0.686178 | 3 | 0 | 3 |
| PPOX | BTBD9 | 0.675279 | 4 | 0 | 3 |
| PPOX | ZNF568 | 0.67516 | 3 | 0 | 3 |
| PPOX | BTNL9 | 0.674101 | 3 | 0 | 3 |
| PPOX | FAM171A1 | 0.665628 | 4 | 0 | 3 |
| PPOX | BEND7 | 0.65465 | 5 | 0 | 4 |
| PPOX | ZNF569 | 0.652257 | 4 | 0 | 3 |
| PPOX | METTL25 | 0.649721 | 3 | 0 | 3 |
| PPOX | FBXL15 | 0.645739 | 5 | 0 | 4 |
| PPOX | BST1 | 0.638421 | 4 | 0 | 3 |
| PPOX | RPS6KL1 | 0.632661 | 3 | 0 | 3 |
| PPOX | SYDE2 | 0.614866 | 3 | 0 | 3 |
| PPOX | EXOSC1 | 0.611612 | 4 | 0 | 3 |
| PPOX | PAFAH2 | 0.601196 | 3 | 0 | 3 |
| PPOX | SOWAHA | 0.600156 | 3 | 0 | 3 |
| PPOX | NKX2-3 | 0.599886 | 4 | 0 | 3 |
| PPOX | SAMD13 | 0.590475 | 5 | 0 | 3 |
For details and further investigation, click here
