| Full name: integrin subunit alpha 7 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.2 | ||
| Entrez ID: 3679 | HGNC ID: HGNC:6143 | Ensembl Gene: ENSG00000135424 | OMIM ID: 600536 |
| Drug and gene relationship at DGIdb | |||
ITGA7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ITGA7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITGA7 | 3679 | 216331_at | -1.0378 | 0.2250 | |
| GSE20347 | ITGA7 | 3679 | 216331_at | -0.2609 | 0.2019 | |
| GSE23400 | ITGA7 | 3679 | 216331_at | -0.6552 | 0.0000 | |
| GSE26886 | ITGA7 | 3679 | 216331_at | -0.0178 | 0.9356 | |
| GSE29001 | ITGA7 | 3679 | 216331_at | -0.2294 | 0.3011 | |
| GSE38129 | ITGA7 | 3679 | 216331_at | -1.1769 | 0.0036 | |
| GSE45670 | ITGA7 | 3679 | 216331_at | -1.1285 | 0.0000 | |
| GSE53622 | ITGA7 | 3679 | 13579 | -1.6350 | 0.0000 | |
| GSE53624 | ITGA7 | 3679 | 13579 | -1.6173 | 0.0000 | |
| GSE63941 | ITGA7 | 3679 | 216331_at | -0.1617 | 0.5417 | |
| GSE77861 | ITGA7 | 3679 | 216331_at | 0.0597 | 0.6031 | |
| GSE97050 | ITGA7 | 3679 | A_23_P128084 | -0.6499 | 0.2468 | |
| SRP064894 | ITGA7 | 3679 | RNAseq | -0.0869 | 0.8464 | |
| SRP133303 | ITGA7 | 3679 | RNAseq | -2.1759 | 0.0000 | |
| SRP159526 | ITGA7 | 3679 | RNAseq | 0.1441 | 0.8311 | |
| SRP193095 | ITGA7 | 3679 | RNAseq | 0.3676 | 0.2306 | |
| SRP219564 | ITGA7 | 3679 | RNAseq | -0.7860 | 0.4175 | |
| TCGA | ITGA7 | 3679 | RNAseq | -0.7939 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by ITGA7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITGA7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITGA7 | 3679 | 6 | 1 | 23 | |
| GSE20123 | ITGA7 | 3679 | 6 | 1 | 23 | |
| GSE43470 | ITGA7 | 3679 | 4 | 0 | 39 | |
| GSE46452 | ITGA7 | 3679 | 8 | 1 | 50 | |
| GSE47630 | ITGA7 | 3679 | 10 | 2 | 28 | |
| GSE54993 | ITGA7 | 3679 | 0 | 5 | 65 | |
| GSE54994 | ITGA7 | 3679 | 4 | 1 | 48 | |
| GSE60625 | ITGA7 | 3679 | 0 | 0 | 11 | |
| GSE74703 | ITGA7 | 3679 | 4 | 0 | 32 | |
| GSE74704 | ITGA7 | 3679 | 4 | 1 | 15 | |
| TCGA | ITGA7 | 3679 | 15 | 10 | 71 |
Total number of gains: 61; Total number of losses: 22; Total Number of normals: 405.
Somatic mutations of ITGA7:
Generating mutation plots.
Highly correlated genes for ITGA7:
Showing top 20/1299 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITGA7 | PPP1R14A | 0.873654 | 6 | 0 | 6 |
| ITGA7 | ANO5 | 0.850186 | 5 | 0 | 5 |
| ITGA7 | XKR4 | 0.842796 | 5 | 0 | 5 |
| ITGA7 | MYOM1 | 0.83722 | 9 | 0 | 9 |
| ITGA7 | CLEC3B | 0.834097 | 3 | 0 | 3 |
| ITGA7 | KCNMB1 | 0.829785 | 11 | 0 | 11 |
| ITGA7 | SGCA | 0.827232 | 9 | 0 | 9 |
| ITGA7 | MRVI1 | 0.826099 | 7 | 0 | 7 |
| ITGA7 | FXYD1 | 0.825782 | 7 | 0 | 7 |
| ITGA7 | ADAMTS9-AS2 | 0.824453 | 4 | 0 | 4 |
| ITGA7 | PPP1R12B | 0.824363 | 10 | 0 | 10 |
| ITGA7 | TCEAL2 | 0.823501 | 8 | 0 | 8 |
| ITGA7 | RBPMS2 | 0.814465 | 7 | 0 | 7 |
| ITGA7 | RAB9B | 0.814242 | 5 | 0 | 5 |
| ITGA7 | PRKAR2B | 0.813292 | 9 | 0 | 9 |
| ITGA7 | HSPB7 | 0.81015 | 10 | 0 | 10 |
| ITGA7 | FENDRR | 0.809825 | 4 | 0 | 4 |
| ITGA7 | CBX7 | 0.8085 | 9 | 0 | 9 |
| ITGA7 | PGR | 0.808419 | 5 | 0 | 5 |
| ITGA7 | DIXDC1 | 0.806609 | 8 | 0 | 8 |
For details and further investigation, click here
