| Full name: aquaporin 1 (Colton blood group) | Alias Symbol: CHIP28 | ||
| Type: protein-coding gene | Cytoband: 7p14.3 | ||
| Entrez ID: 358 | HGNC ID: HGNC:633 | Ensembl Gene: ENSG00000240583 | OMIM ID: 107776 |
| Drug and gene relationship at DGIdb | |||
AQP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04924 | Renin secretion |
Expression of AQP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AQP1 | 358 | 209047_at | -1.7114 | 0.1218 | |
| GSE20347 | AQP1 | 358 | 209047_at | -1.0588 | 0.0058 | |
| GSE23400 | AQP1 | 358 | 209047_at | -1.1043 | 0.0000 | |
| GSE26886 | AQP1 | 358 | 209047_at | -0.8585 | 0.0088 | |
| GSE29001 | AQP1 | 358 | 209047_at | -0.6978 | 0.0603 | |
| GSE38129 | AQP1 | 358 | 209047_at | -1.4622 | 0.0009 | |
| GSE45670 | AQP1 | 358 | 209047_at | -2.0992 | 0.0000 | |
| GSE53622 | AQP1 | 358 | 18410 | -1.6137 | 0.0000 | |
| GSE53624 | AQP1 | 358 | 18410 | -1.2700 | 0.0000 | |
| GSE63941 | AQP1 | 358 | 207542_s_at | 0.4289 | 0.1122 | |
| GSE77861 | AQP1 | 358 | 207542_s_at | -0.1006 | 0.7097 | |
| GSE97050 | AQP1 | 358 | A_33_P3253723 | -1.0053 | 0.1616 | |
| SRP007169 | AQP1 | 358 | RNAseq | -0.6989 | 0.1218 | |
| SRP008496 | AQP1 | 358 | RNAseq | -0.2237 | 0.5424 | |
| SRP064894 | AQP1 | 358 | RNAseq | -0.0475 | 0.9191 | |
| SRP133303 | AQP1 | 358 | RNAseq | -1.1328 | 0.0393 | |
| SRP159526 | AQP1 | 358 | RNAseq | -0.7102 | 0.1234 | |
| SRP193095 | AQP1 | 358 | RNAseq | 0.0844 | 0.7744 | |
| SRP219564 | AQP1 | 358 | RNAseq | -0.0579 | 0.9542 | |
| TCGA | AQP1 | 358 | RNAseq | -0.4969 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by AQP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AQP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AQP1 | 358 | 15 | 0 | 15 | |
| GSE20123 | AQP1 | 358 | 15 | 0 | 15 | |
| GSE43470 | AQP1 | 358 | 4 | 0 | 39 | |
| GSE46452 | AQP1 | 358 | 11 | 1 | 47 | |
| GSE47630 | AQP1 | 358 | 8 | 1 | 31 | |
| GSE54993 | AQP1 | 358 | 0 | 6 | 64 | |
| GSE54994 | AQP1 | 358 | 19 | 3 | 31 | |
| GSE60625 | AQP1 | 358 | 0 | 0 | 11 | |
| GSE74703 | AQP1 | 358 | 4 | 0 | 32 | |
| GSE74704 | AQP1 | 358 | 9 | 0 | 11 | |
| TCGA | AQP1 | 358 | 55 | 6 | 35 |
Total number of gains: 140; Total number of losses: 17; Total Number of normals: 331.
Somatic mutations of AQP1:
Generating mutation plots.
Highly correlated genes for AQP1:
Showing top 20/977 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AQP1 | CYP21A2 | 0.870974 | 3 | 0 | 3 |
| AQP1 | SORCS1 | 0.853767 | 4 | 0 | 4 |
| AQP1 | TNS1 | 0.825946 | 9 | 0 | 9 |
| AQP1 | SMOC2 | 0.823177 | 6 | 0 | 6 |
| AQP1 | XKR4 | 0.815198 | 5 | 0 | 5 |
| AQP1 | CLEC3B | 0.814305 | 3 | 0 | 3 |
| AQP1 | CDH19 | 0.803224 | 8 | 0 | 8 |
| AQP1 | PPP1R14A | 0.800518 | 6 | 0 | 6 |
| AQP1 | PYGM | 0.79111 | 9 | 0 | 9 |
| AQP1 | CHRDL1 | 0.787411 | 10 | 0 | 9 |
| AQP1 | BCHE | 0.786798 | 8 | 0 | 8 |
| AQP1 | PGM5 | 0.781059 | 9 | 0 | 8 |
| AQP1 | ATP1A2 | 0.780117 | 11 | 0 | 10 |
| AQP1 | PPP1R12B | 0.776126 | 11 | 0 | 10 |
| AQP1 | ITGA7 | 0.773199 | 11 | 0 | 10 |
| AQP1 | SYNM | 0.772423 | 10 | 0 | 9 |
| AQP1 | RAB9B | 0.766036 | 6 | 0 | 5 |
| AQP1 | FBLN1 | 0.765003 | 8 | 0 | 8 |
| AQP1 | PREX2 | 0.764966 | 4 | 0 | 4 |
| AQP1 | RGS5 | 0.76482 | 12 | 0 | 12 |
For details and further investigation, click here
