| Full name: TIMP metallopeptidase inhibitor 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q12.3 | ||
| Entrez ID: 7078 | HGNC ID: HGNC:11822 | Ensembl Gene: ENSG00000100234 | OMIM ID: 188826 |
| Drug and gene relationship at DGIdb | |||
TIMP3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of TIMP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TIMP3 | 7078 | 201150_s_at | -0.9552 | 0.1347 | |
| GSE20347 | TIMP3 | 7078 | 201150_s_at | 0.3792 | 0.3682 | |
| GSE23400 | TIMP3 | 7078 | 201148_s_at | -0.0537 | 0.6286 | |
| GSE26886 | TIMP3 | 7078 | 201148_s_at | 0.2219 | 0.4417 | |
| GSE29001 | TIMP3 | 7078 | 201148_s_at | 0.5287 | 0.1590 | |
| GSE38129 | TIMP3 | 7078 | 201150_s_at | -0.2859 | 0.6210 | |
| GSE45670 | TIMP3 | 7078 | 201150_s_at | -2.8056 | 0.0000 | |
| GSE63941 | TIMP3 | 7078 | 201148_s_at | -2.6828 | 0.0020 | |
| GSE77861 | TIMP3 | 7078 | 201148_s_at | 0.1246 | 0.6124 | |
| GSE97050 | TIMP3 | 7078 | A_23_P399078 | -0.6817 | 0.3458 | |
| SRP007169 | TIMP3 | 7078 | RNAseq | 2.7864 | 0.0000 | |
| SRP008496 | TIMP3 | 7078 | RNAseq | 3.5536 | 0.0000 | |
| SRP064894 | TIMP3 | 7078 | RNAseq | -0.3137 | 0.4108 | |
| SRP133303 | TIMP3 | 7078 | RNAseq | 0.3483 | 0.3977 | |
| SRP159526 | TIMP3 | 7078 | RNAseq | -0.3434 | 0.5066 | |
| SRP193095 | TIMP3 | 7078 | RNAseq | 1.6023 | 0.0000 | |
| SRP219564 | TIMP3 | 7078 | RNAseq | -0.3406 | 0.5756 | |
| TCGA | TIMP3 | 7078 | RNAseq | -0.3220 | 0.0024 |
Upregulated datasets: 3; Downregulated datasets: 2.
Survival by TIMP3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TIMP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TIMP3 | 7078 | 4 | 5 | 21 | |
| GSE20123 | TIMP3 | 7078 | 3 | 4 | 23 | |
| GSE43470 | TIMP3 | 7078 | 5 | 5 | 33 | |
| GSE46452 | TIMP3 | 7078 | 31 | 1 | 27 | |
| GSE47630 | TIMP3 | 7078 | 8 | 5 | 27 | |
| GSE54993 | TIMP3 | 7078 | 3 | 6 | 61 | |
| GSE54994 | TIMP3 | 7078 | 9 | 10 | 34 | |
| GSE60625 | TIMP3 | 7078 | 5 | 0 | 6 | |
| GSE74703 | TIMP3 | 7078 | 4 | 5 | 27 | |
| GSE74704 | TIMP3 | 7078 | 1 | 1 | 18 | |
| TCGA | TIMP3 | 7078 | 27 | 15 | 54 |
Total number of gains: 100; Total number of losses: 57; Total Number of normals: 331.
Somatic mutations of TIMP3:
Generating mutation plots.
Highly correlated genes for TIMP3:
Showing top 20/1017 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TIMP3 | XKR4 | 0.827529 | 3 | 0 | 3 |
| TIMP3 | MRVI1 | 0.821599 | 4 | 0 | 4 |
| TIMP3 | PPP1R14A | 0.814191 | 3 | 0 | 3 |
| TIMP3 | ITGA9 | 0.81308 | 3 | 0 | 3 |
| TIMP3 | GFRA1 | 0.810135 | 4 | 0 | 4 |
| TIMP3 | CPQ | 0.805346 | 5 | 0 | 5 |
| TIMP3 | TBX5-AS1 | 0.804535 | 3 | 0 | 3 |
| TIMP3 | PABPC5 | 0.801572 | 3 | 0 | 3 |
| TIMP3 | NEGR1 | 0.794593 | 5 | 0 | 5 |
| TIMP3 | FIBIN | 0.791576 | 5 | 0 | 5 |
| TIMP3 | SYNC | 0.786331 | 7 | 0 | 7 |
| TIMP3 | TCEAL3 | 0.784205 | 3 | 0 | 3 |
| TIMP3 | INMT | 0.784199 | 4 | 0 | 4 |
| TIMP3 | NTN4 | 0.783306 | 3 | 0 | 3 |
| TIMP3 | RBM24 | 0.783271 | 4 | 0 | 4 |
| TIMP3 | SMIM10 | 0.779348 | 3 | 0 | 3 |
| TIMP3 | RGMB | 0.779105 | 3 | 0 | 3 |
| TIMP3 | BEND5 | 0.77707 | 4 | 0 | 4 |
| TIMP3 | IL17D | 0.775557 | 4 | 0 | 4 |
| TIMP3 | C14orf28 | 0.772582 | 3 | 0 | 3 |
For details and further investigation, click here
