| Full name: protein phosphatase 2 regulatory subunit B''gamma | Alias Symbol: FLJ20644|G4-1|G5PR | ||
| Type: protein-coding gene | Cytoband: 14q13.2 | ||
| Entrez ID: 55012 | HGNC ID: HGNC:17485 | Ensembl Gene: ENSG00000092020 | OMIM ID: 615902 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PPP2R3C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04071 | Sphingolipid signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04261 | Adrenergic signaling in cardiomyocytes | |
| hsa04728 | Dopaminergic synapse |
Expression of PPP2R3C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP2R3C | 55012 | 218852_at | 0.1904 | 0.8648 | |
| GSE20347 | PPP2R3C | 55012 | 218852_at | 0.3603 | 0.1481 | |
| GSE23400 | PPP2R3C | 55012 | 218852_at | 0.3907 | 0.0000 | |
| GSE26886 | PPP2R3C | 55012 | 218852_at | -0.6751 | 0.0173 | |
| GSE29001 | PPP2R3C | 55012 | 218852_at | 0.3582 | 0.5251 | |
| GSE38129 | PPP2R3C | 55012 | 218852_at | 0.0884 | 0.7279 | |
| GSE45670 | PPP2R3C | 55012 | 218852_at | -0.1740 | 0.2836 | |
| GSE53622 | PPP2R3C | 55012 | 15315 | 0.1037 | 0.2909 | |
| GSE53624 | PPP2R3C | 55012 | 15315 | 0.2427 | 0.0032 | |
| GSE63941 | PPP2R3C | 55012 | 218852_at | -0.2787 | 0.6662 | |
| GSE77861 | PPP2R3C | 55012 | 218852_at | 0.8502 | 0.1573 | |
| GSE97050 | PPP2R3C | 55012 | A_23_P88201 | 0.2315 | 0.4161 | |
| SRP007169 | PPP2R3C | 55012 | RNAseq | 0.4220 | 0.3652 | |
| SRP008496 | PPP2R3C | 55012 | RNAseq | 0.2037 | 0.5002 | |
| SRP064894 | PPP2R3C | 55012 | RNAseq | 0.2439 | 0.0821 | |
| SRP133303 | PPP2R3C | 55012 | RNAseq | 0.6866 | 0.0065 | |
| SRP159526 | PPP2R3C | 55012 | RNAseq | -0.0435 | 0.8777 | |
| SRP193095 | PPP2R3C | 55012 | RNAseq | -0.0887 | 0.4604 | |
| SRP219564 | PPP2R3C | 55012 | RNAseq | -0.0396 | 0.9194 | |
| TCGA | PPP2R3C | 55012 | RNAseq | -0.1085 | 0.0695 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPP2R3C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP2R3C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP2R3C | 55012 | 10 | 4 | 16 | |
| GSE20123 | PPP2R3C | 55012 | 11 | 4 | 15 | |
| GSE43470 | PPP2R3C | 55012 | 9 | 2 | 32 | |
| GSE46452 | PPP2R3C | 55012 | 18 | 2 | 39 | |
| GSE47630 | PPP2R3C | 55012 | 11 | 10 | 19 | |
| GSE54993 | PPP2R3C | 55012 | 3 | 10 | 57 | |
| GSE54994 | PPP2R3C | 55012 | 19 | 5 | 29 | |
| GSE60625 | PPP2R3C | 55012 | 0 | 2 | 9 | |
| GSE74703 | PPP2R3C | 55012 | 8 | 2 | 26 | |
| GSE74704 | PPP2R3C | 55012 | 5 | 3 | 12 | |
| TCGA | PPP2R3C | 55012 | 32 | 15 | 49 |
Total number of gains: 126; Total number of losses: 59; Total Number of normals: 303.
Somatic mutations of PPP2R3C:
Generating mutation plots.
Highly correlated genes for PPP2R3C:
Showing top 20/573 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP2R3C | USP37 | 0.789743 | 3 | 0 | 3 |
| PPP2R3C | USP24 | 0.785145 | 3 | 0 | 3 |
| PPP2R3C | BRMS1L | 0.781912 | 6 | 0 | 6 |
| PPP2R3C | LGALS8 | 0.770794 | 3 | 0 | 3 |
| PPP2R3C | ATG4C | 0.757344 | 4 | 0 | 3 |
| PPP2R3C | LRRC58 | 0.756779 | 3 | 0 | 3 |
| PPP2R3C | MED26 | 0.749932 | 3 | 0 | 3 |
| PPP2R3C | NUB1 | 0.7485 | 4 | 0 | 4 |
| PPP2R3C | SON | 0.743005 | 3 | 0 | 3 |
| PPP2R3C | MRPL9 | 0.736218 | 3 | 0 | 3 |
| PPP2R3C | EFCAB7 | 0.734674 | 4 | 0 | 3 |
| PPP2R3C | WSB2 | 0.729173 | 3 | 0 | 3 |
| PPP2R3C | CLEC14A | 0.726529 | 3 | 0 | 3 |
| PPP2R3C | TRIT1 | 0.725927 | 3 | 0 | 3 |
| PPP2R3C | AIDA | 0.722973 | 5 | 0 | 5 |
| PPP2R3C | BCAS2 | 0.722871 | 3 | 0 | 3 |
| PPP2R3C | TRAPPC2 | 0.720936 | 3 | 0 | 3 |
| PPP2R3C | ATG14 | 0.718478 | 3 | 0 | 3 |
| PPP2R3C | HNRNPUL2 | 0.715525 | 3 | 0 | 3 |
| PPP2R3C | VAMP3 | 0.708686 | 4 | 0 | 3 |
For details and further investigation, click here
