SLIT2

 

Full name: slit guidance ligand 2 Alias Symbol: Slit-2
Type: protein-coding gene Cytoband: 4p15.31
Entrez ID: 9353 HGNC ID: HGNC:11086 Ensembl Gene: ENSG00000145147 OMIM ID: 603746
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

SLIT2 involved pathways:

KEGG pathway Description View
hsa04360Axon guidance

 

Expression of SLIT2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SLIT2 9353 209897_s_at -1.7013 0.1938
GSE20347 SLIT2 9353 209897_s_at -0.2778 0.1603
GSE23400 SLIT2 9353 209897_s_at -0.4356 0.0052
GSE26886 SLIT2 9353 209897_s_at 0.7111 0.0171
GSE29001 SLIT2 9353 209897_s_at 0.2306 0.5001
GSE38129 SLIT2 9353 209897_s_at -0.8068 0.0374
GSE45670 SLIT2 9353 209897_s_at -1.9510 0.0000
GSE53622 SLIT2 9353 40486 -0.8646 0.0001
GSE53624 SLIT2 9353 40486 -0.7024 0.0002
GSE63941 SLIT2 9353 209897_s_at -1.6921 0.2098
GSE77861 SLIT2 9353 209897_s_at 0.3190 0.0703
GSE97050 SLIT2 9353 A_23_P144348 -1.0649 0.1186
SRP007169 SLIT2 9353 RNAseq 3.6234 0.0000
SRP008496 SLIT2 9353 RNAseq 4.0037 0.0000
SRP064894 SLIT2 9353 RNAseq -0.0074 0.9863
SRP133303 SLIT2 9353 RNAseq -0.8178 0.0663
SRP159526 SLIT2 9353 RNAseq 0.6605 0.2188
SRP193095 SLIT2 9353 RNAseq 0.1403 0.6060
SRP219564 SLIT2 9353 RNAseq 0.4158 0.7268
TCGA SLIT2 9353 RNAseq -0.7991 0.0039

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by SLIT2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SLIT2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SLIT2 9353 0 18 12
GSE20123 SLIT2 9353 0 18 12
GSE43470 SLIT2 9353 0 15 28
GSE46452 SLIT2 9353 1 36 22
GSE47630 SLIT2 9353 1 19 20
GSE54993 SLIT2 9353 9 0 61
GSE54994 SLIT2 9353 4 12 37
GSE60625 SLIT2 9353 0 0 11
GSE74703 SLIT2 9353 0 13 23
GSE74704 SLIT2 9353 0 11 9
TCGA SLIT2 9353 9 48 39

Total number of gains: 24; Total number of losses: 190; Total Number of normals: 274.  

 

Somatic mutations of SLIT2:

 

Generating mutation plots.

 

Highly correlated genes for SLIT2:

 

Showing top 20/1093 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SLIT2PGR0.832409505
SLIT2MEOX20.828274808
SLIT2RNASE40.817791505
SLIT2OGN0.815115808
SLIT2DIXDC10.810016908
SLIT2PLP10.80594707
SLIT2PEG30.802296606
SLIT2CD340.800236606
SLIT2MYOC0.799076808
SLIT2PPP1R12B0.79635808
SLIT2ADARB10.790912707
SLIT2DMPK0.790255606
SLIT2CASQ20.789397808
SLIT2LRFN50.785435404
SLIT2DPT0.780743808
SLIT2ANGPTL10.779714505
SLIT2LMO30.778707908
SLIT2XKR40.77663505
SLIT2FLNC0.775314807
SLIT2TMOD10.773229706

For details and further investigation, click here