| Full name: BCL2 interacting protein 2 | Alias Symbol: Nip2|BNIP-2 | ||
| Type: protein-coding gene | Cytoband: 15q22.2 | ||
| Entrez ID: 663 | HGNC ID: HGNC:1083 | Ensembl Gene: ENSG00000140299 | OMIM ID: 603292 |
| Drug and gene relationship at DGIdb | |||
Expression of BNIP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BNIP2 | 663 | 209308_s_at | 0.0340 | 0.9611 | |
| GSE20347 | BNIP2 | 663 | 209308_s_at | 0.4369 | 0.0027 | |
| GSE23400 | BNIP2 | 663 | 209308_s_at | 0.1868 | 0.0001 | |
| GSE26886 | BNIP2 | 663 | 226280_at | 0.0195 | 0.9380 | |
| GSE29001 | BNIP2 | 663 | 209308_s_at | 0.2954 | 0.1189 | |
| GSE38129 | BNIP2 | 663 | 209308_s_at | 0.3676 | 0.0021 | |
| GSE45670 | BNIP2 | 663 | 226280_at | -0.6372 | 0.0005 | |
| GSE53622 | BNIP2 | 663 | 19452 | -0.1206 | 0.0646 | |
| GSE53624 | BNIP2 | 663 | 19452 | 0.0996 | 0.0791 | |
| GSE63941 | BNIP2 | 663 | 209308_s_at | -0.6104 | 0.1401 | |
| GSE77861 | BNIP2 | 663 | 226280_at | 0.2014 | 0.4626 | |
| GSE97050 | BNIP2 | 663 | A_33_P3227467 | -0.3941 | 0.1392 | |
| SRP007169 | BNIP2 | 663 | RNAseq | -0.0549 | 0.8910 | |
| SRP008496 | BNIP2 | 663 | RNAseq | 0.1650 | 0.4447 | |
| SRP064894 | BNIP2 | 663 | RNAseq | -0.0700 | 0.6918 | |
| SRP133303 | BNIP2 | 663 | RNAseq | 0.1526 | 0.1977 | |
| SRP159526 | BNIP2 | 663 | RNAseq | -0.4400 | 0.2325 | |
| SRP193095 | BNIP2 | 663 | RNAseq | 0.1293 | 0.2450 | |
| SRP219564 | BNIP2 | 663 | RNAseq | -0.3697 | 0.1449 | |
| TCGA | BNIP2 | 663 | RNAseq | 0.1273 | 0.0101 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BNIP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BNIP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BNIP2 | 663 | 6 | 4 | 20 | |
| GSE20123 | BNIP2 | 663 | 6 | 3 | 21 | |
| GSE43470 | BNIP2 | 663 | 4 | 4 | 35 | |
| GSE46452 | BNIP2 | 663 | 3 | 7 | 49 | |
| GSE47630 | BNIP2 | 663 | 8 | 10 | 22 | |
| GSE54993 | BNIP2 | 663 | 5 | 6 | 59 | |
| GSE54994 | BNIP2 | 663 | 6 | 8 | 39 | |
| GSE60625 | BNIP2 | 663 | 4 | 0 | 7 | |
| GSE74703 | BNIP2 | 663 | 4 | 3 | 29 | |
| GSE74704 | BNIP2 | 663 | 2 | 3 | 15 | |
| TCGA | BNIP2 | 663 | 10 | 17 | 69 |
Total number of gains: 58; Total number of losses: 65; Total Number of normals: 365.
Somatic mutations of BNIP2:
Generating mutation plots.
Highly correlated genes for BNIP2:
Showing top 20/600 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BNIP2 | TMEM60 | 0.776075 | 3 | 0 | 3 |
| BNIP2 | PLEKHM3 | 0.764422 | 3 | 0 | 3 |
| BNIP2 | PPP3CB | 0.753591 | 3 | 0 | 3 |
| BNIP2 | CRBN | 0.75062 | 3 | 0 | 3 |
| BNIP2 | MAPK1 | 0.745716 | 3 | 0 | 3 |
| BNIP2 | VPS36 | 0.745054 | 3 | 0 | 3 |
| BNIP2 | ZNF260 | 0.737656 | 3 | 0 | 3 |
| BNIP2 | UNC45A | 0.736266 | 3 | 0 | 3 |
| BNIP2 | ZNF704 | 0.728674 | 3 | 0 | 3 |
| BNIP2 | RHBDD1 | 0.726383 | 3 | 0 | 3 |
| BNIP2 | LUC7L2 | 0.724097 | 3 | 0 | 3 |
| BNIP2 | CTPS2 | 0.715342 | 3 | 0 | 3 |
| BNIP2 | SIN3A | 0.711849 | 4 | 0 | 4 |
| BNIP2 | DHX30 | 0.706408 | 3 | 0 | 3 |
| BNIP2 | ALKBH3 | 0.703616 | 3 | 0 | 3 |
| BNIP2 | ZNF44 | 0.70111 | 3 | 0 | 3 |
| BNIP2 | EIF4G2 | 0.69503 | 4 | 0 | 4 |
| BNIP2 | FBXL3 | 0.691504 | 4 | 0 | 4 |
| BNIP2 | COX5A | 0.683321 | 3 | 0 | 3 |
| BNIP2 | ACBD5 | 0.682111 | 3 | 0 | 3 |
For details and further investigation, click here
