| Full name: protein phosphatase 4 regulatory subunit 4 | Alias Symbol: PP4R4|CFAP14 | ||
| Type: protein-coding gene | Cytoband: 14q32.2 | ||
| Entrez ID: 57718 | HGNC ID: HGNC:23788 | Ensembl Gene: ENSG00000119698 | OMIM ID: 616790 |
| Drug and gene relationship at DGIdb | |||
Expression of PPP4R4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP4R4 | 57718 | 233002_at | 2.2397 | 0.1083 | |
| GSE20347 | PPP4R4 | 57718 | 220672_at | 0.3140 | 0.1003 | |
| GSE23400 | PPP4R4 | 57718 | 220673_s_at | 0.0822 | 0.0151 | |
| GSE26886 | PPP4R4 | 57718 | 220672_at | 1.0895 | 0.0009 | |
| GSE29001 | PPP4R4 | 57718 | 220673_s_at | 0.1302 | 0.3087 | |
| GSE38129 | PPP4R4 | 57718 | 220673_s_at | 0.2801 | 0.0409 | |
| GSE45670 | PPP4R4 | 57718 | 233002_at | 1.6142 | 0.0150 | |
| GSE53622 | PPP4R4 | 57718 | 79484 | 2.4071 | 0.0000 | |
| GSE53624 | PPP4R4 | 57718 | 74792 | 1.9647 | 0.0000 | |
| GSE63941 | PPP4R4 | 57718 | 233002_at | -1.2650 | 0.3951 | |
| GSE77861 | PPP4R4 | 57718 | 220672_at | 0.1366 | 0.1920 | |
| GSE97050 | PPP4R4 | 57718 | A_33_P3298206 | 0.7324 | 0.1449 | |
| SRP133303 | PPP4R4 | 57718 | RNAseq | 3.5679 | 0.0000 | |
| SRP193095 | PPP4R4 | 57718 | RNAseq | 3.8370 | 0.0000 | |
| SRP219564 | PPP4R4 | 57718 | RNAseq | 5.1754 | 0.0000 | |
| TCGA | PPP4R4 | 57718 | RNAseq | 0.2881 | 0.4825 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by PPP4R4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP4R4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP4R4 | 57718 | 9 | 4 | 17 | |
| GSE20123 | PPP4R4 | 57718 | 9 | 3 | 18 | |
| GSE43470 | PPP4R4 | 57718 | 7 | 3 | 33 | |
| GSE46452 | PPP4R4 | 57718 | 16 | 3 | 40 | |
| GSE47630 | PPP4R4 | 57718 | 11 | 8 | 21 | |
| GSE54993 | PPP4R4 | 57718 | 3 | 8 | 59 | |
| GSE54994 | PPP4R4 | 57718 | 20 | 4 | 29 | |
| GSE60625 | PPP4R4 | 57718 | 0 | 2 | 9 | |
| GSE74703 | PPP4R4 | 57718 | 6 | 3 | 27 | |
| GSE74704 | PPP4R4 | 57718 | 5 | 3 | 12 | |
| TCGA | PPP4R4 | 57718 | 30 | 21 | 45 |
Total number of gains: 116; Total number of losses: 62; Total Number of normals: 310.
Somatic mutations of PPP4R4:
Generating mutation plots.
Highly correlated genes for PPP4R4:
Showing top 20/1182 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP4R4 | PGM2L1 | 0.784557 | 4 | 0 | 4 |
| PPP4R4 | ZNF114 | 0.777898 | 4 | 0 | 4 |
| PPP4R4 | MAPK1IP1L | 0.725612 | 3 | 0 | 3 |
| PPP4R4 | GSDMB | 0.715128 | 3 | 0 | 3 |
| PPP4R4 | SLC36A4 | 0.714871 | 3 | 0 | 3 |
| PPP4R4 | NOL6 | 0.709498 | 3 | 0 | 3 |
| PPP4R4 | DMXL2 | 0.70818 | 3 | 0 | 3 |
| PPP4R4 | OSGEPL1 | 0.702296 | 4 | 0 | 4 |
| PPP4R4 | SPRED1 | 0.700459 | 3 | 0 | 3 |
| PPP4R4 | CXXC1 | 0.699801 | 3 | 0 | 3 |
| PPP4R4 | BORA | 0.69805 | 4 | 0 | 4 |
| PPP4R4 | SH2B2 | 0.696503 | 4 | 0 | 4 |
| PPP4R4 | SLC39A3 | 0.69443 | 4 | 0 | 4 |
| PPP4R4 | BRD9 | 0.691144 | 5 | 0 | 4 |
| PPP4R4 | DCBLD1 | 0.687049 | 7 | 0 | 7 |
| PPP4R4 | KDELR3 | 0.686973 | 6 | 0 | 6 |
| PPP4R4 | MSTO1 | 0.685687 | 3 | 0 | 3 |
| PPP4R4 | FLVCR1 | 0.683041 | 4 | 0 | 4 |
| PPP4R4 | SLC2A4RG | 0.682733 | 3 | 0 | 3 |
| PPP4R4 | ESM1 | 0.681639 | 6 | 0 | 5 |
For details and further investigation, click here
