| Full name: feline leukemia virus subgroup C cellular receptor 1 | Alias Symbol: FLVCR|MFSD7B|PCA|SLC49A1 | ||
| Type: protein-coding gene | Cytoband: 1q32.3 | ||
| Entrez ID: 28982 | HGNC ID: HGNC:24682 | Ensembl Gene: ENSG00000162769 | OMIM ID: 609144 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FLVCR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FLVCR1 | 28982 | 228191_at | 1.5022 | 0.0111 | |
| GSE26886 | FLVCR1 | 28982 | 222906_at | 1.2457 | 0.0001 | |
| GSE45670 | FLVCR1 | 28982 | 228191_at | 0.6863 | 0.0134 | |
| GSE53622 | FLVCR1 | 28982 | 63671 | 1.0735 | 0.0000 | |
| GSE53624 | FLVCR1 | 28982 | 63671 | 1.3729 | 0.0000 | |
| GSE63941 | FLVCR1 | 28982 | 228191_at | 1.0576 | 0.1016 | |
| GSE77861 | FLVCR1 | 28982 | 228191_at | 1.6552 | 0.0139 | |
| GSE97050 | FLVCR1 | 28982 | A_23_P12113 | 0.5214 | 0.1538 | |
| SRP007169 | FLVCR1 | 28982 | RNAseq | 1.3629 | 0.0039 | |
| SRP008496 | FLVCR1 | 28982 | RNAseq | 2.0579 | 0.0000 | |
| SRP064894 | FLVCR1 | 28982 | RNAseq | 0.3146 | 0.1453 | |
| SRP133303 | FLVCR1 | 28982 | RNAseq | 0.6443 | 0.0006 | |
| SRP159526 | FLVCR1 | 28982 | RNAseq | 1.2846 | 0.0000 | |
| SRP193095 | FLVCR1 | 28982 | RNAseq | 0.1021 | 0.5520 | |
| SRP219564 | FLVCR1 | 28982 | RNAseq | 0.7713 | 0.0613 | |
| TCGA | FLVCR1 | 28982 | RNAseq | 0.2417 | 0.0144 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by FLVCR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FLVCR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FLVCR1 | 28982 | 10 | 0 | 20 | |
| GSE20123 | FLVCR1 | 28982 | 10 | 0 | 20 | |
| GSE43470 | FLVCR1 | 28982 | 7 | 0 | 36 | |
| GSE46452 | FLVCR1 | 28982 | 3 | 1 | 55 | |
| GSE47630 | FLVCR1 | 28982 | 15 | 0 | 25 | |
| GSE54993 | FLVCR1 | 28982 | 0 | 6 | 64 | |
| GSE54994 | FLVCR1 | 28982 | 13 | 0 | 40 | |
| GSE60625 | FLVCR1 | 28982 | 0 | 0 | 11 | |
| GSE74703 | FLVCR1 | 28982 | 7 | 0 | 29 | |
| GSE74704 | FLVCR1 | 28982 | 4 | 0 | 16 | |
| TCGA | FLVCR1 | 28982 | 45 | 3 | 48 |
Total number of gains: 114; Total number of losses: 10; Total Number of normals: 364.
Somatic mutations of FLVCR1:
Generating mutation plots.
Highly correlated genes for FLVCR1:
Showing top 20/1890 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FLVCR1 | LRRC58 | 0.830542 | 4 | 0 | 4 |
| FLVCR1 | MTERF3 | 0.815292 | 4 | 0 | 4 |
| FLVCR1 | PPP1R16A | 0.800942 | 3 | 0 | 3 |
| FLVCR1 | ARHGEF11 | 0.791711 | 3 | 0 | 3 |
| FLVCR1 | UCK2 | 0.788763 | 3 | 0 | 3 |
| FLVCR1 | PYCR2 | 0.784451 | 3 | 0 | 3 |
| FLVCR1 | URB2 | 0.783345 | 7 | 0 | 7 |
| FLVCR1 | TFRC | 0.773908 | 6 | 0 | 6 |
| FLVCR1 | COG2 | 0.773089 | 7 | 0 | 7 |
| FLVCR1 | DNAJC2 | 0.77179 | 7 | 0 | 7 |
| FLVCR1 | RPN1 | 0.769779 | 5 | 0 | 5 |
| FLVCR1 | TMEM97 | 0.767937 | 8 | 0 | 7 |
| FLVCR1 | U2SURP | 0.762925 | 5 | 0 | 5 |
| FLVCR1 | LIN9 | 0.762115 | 7 | 0 | 7 |
| FLVCR1 | AURKAIP1 | 0.759473 | 3 | 0 | 3 |
| FLVCR1 | NAP1L1 | 0.758035 | 3 | 0 | 3 |
| FLVCR1 | SGTB | 0.757185 | 3 | 0 | 3 |
| FLVCR1 | ZXDB | 0.754054 | 3 | 0 | 3 |
| FLVCR1 | ERVW-1 | 0.750623 | 3 | 0 | 3 |
| FLVCR1 | HEATR1 | 0.749804 | 9 | 0 | 8 |
For details and further investigation, click here
