Full name: BORA aurora kinase A activator	Alias Symbol: FLJ22624
Type: protein-coding gene	Cytoband: 13q21.33
Entrez ID: 79866	HGNC ID: HGNC:24724	Ensembl Gene: ENSG00000136122	OMIM ID: 610510
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 137/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of BORA:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	BORA	79866	219544_at	1.4617	0.1152	Show
GSE20347	BORA	79866	219544_at	1.2355	0.0000	Show
GSE23400	BORA	79866	219544_at	0.4507	0.0000	Show
GSE26886	BORA	79866	219544_at	0.6870	0.0249	Show
GSE29001	BORA	79866	219544_at	1.3154	0.0015	Show
GSE38129	BORA	79866	219544_at	1.4015	0.0000	Show
GSE45670	BORA	79866	219544_at	1.3788	0.0000	Show
GSE63941	BORA	79866	219544_at	2.3550	0.0006	Show
GSE77861	BORA	79866	219544_at	0.7320	0.0242	Show
GSE97050	BORA	79866	A_23_P25626	0.4342	0.1131	Show
SRP007169	BORA	79866	RNAseq	1.3810	0.0014	Show
SRP008496	BORA	79866	RNAseq	1.5499	0.0005	Show
SRP064894	BORA	79866	RNAseq	1.2496	0.0000	Show
SRP133303	BORA	79866	RNAseq	1.4978	0.0000	Show
SRP159526	BORA	79866	RNAseq	1.2194	0.0104	Show
SRP193095	BORA	79866	RNAseq	0.3483	0.0139	Show
SRP219564	BORA	79866	RNAseq	1.2467	0.0693	Show

Upregulated datasets: 10; Downregulated datasets: 0.  Download Data

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Copy number change of BORA:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	BORA	79866	3	10	17	Show
GSE20123	BORA	79866	3	9	18	Show
GSE43470	BORA	79866	6	10	27	Show
GSE46452	BORA	79866	2	31	26	Show
GSE47630	BORA	79866	3	26	11	Show
GSE54993	BORA	79866	11	3	56	Show
GSE54994	BORA	79866	4	13	36	Show
GSE60625	BORA	79866	0	3	8	Show
GSE74703	BORA	79866	4	8	24	Show
GSE74704	BORA	79866	1	8	11	Show
TCGA	BORA	79866	13	33	50	Show

Total number of gains: 50; Total number of losses: 154; Total Number of normals: 284.  Download Data

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Somatic mutations of BORA:

 

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Highly correlated genes for BORA:

 

Showing top 20/1911 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
BORA	CDCA2	0.842081	6	0	6
BORA	BUB1	0.832698	8	0	8
BORA	ANLN	0.825764	6	0	6
BORA	NUF2	0.822024	6	0	6
BORA	TTK	0.81125	10	0	10
BORA	DEPDC1B	0.80982	5	0	5
BORA	CCNB2	0.806237	9	0	9
BORA	TMEM138	0.805575	4	0	4
BORA	ASPM	0.805533	10	0	10
BORA	TPX2	0.805229	10	0	10
BORA	RAD51AP1	0.804969	9	0	9
BORA	YWHAG	0.801027	4	0	4
BORA	NUSAP1	0.800042	10	0	10
BORA	CDCA3	0.799799	10	0	10
BORA	UBE2C	0.79755	10	0	10
BORA	FOXM1	0.794631	9	0	9
BORA	KIF14	0.792259	10	0	10
BORA	NEK2	0.791868	10	0	10
BORA	NEK3	0.791645	3	0	3
BORA	DLGAP5	0.789852	9	0	9

For details and further investigation, click here