| Full name: gasdermin B | Alias Symbol: PRO2521 | ||
| Type: protein-coding gene | Cytoband: 17q21.1 | ||
| Entrez ID: 55876 | HGNC ID: HGNC:23690 | Ensembl Gene: ENSG00000073605 | OMIM ID: 611221 |
| Drug and gene relationship at DGIdb | |||
Expression of GSDMB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GSDMB | 55876 | 219233_s_at | 0.2751 | 0.5518 | |
| GSE20347 | GSDMB | 55876 | 219233_s_at | 0.5150 | 0.0220 | |
| GSE23400 | GSDMB | 55876 | 219233_s_at | 0.4791 | 0.0000 | |
| GSE26886 | GSDMB | 55876 | 219233_s_at | 0.7201 | 0.0240 | |
| GSE29001 | GSDMB | 55876 | 219233_s_at | 0.6667 | 0.0717 | |
| GSE38129 | GSDMB | 55876 | 219233_s_at | 0.5318 | 0.0159 | |
| GSE45670 | GSDMB | 55876 | 219233_s_at | 0.6651 | 0.0291 | |
| GSE53622 | GSDMB | 55876 | 56491 | 0.7476 | 0.0003 | |
| GSE53624 | GSDMB | 55876 | 15911 | 0.5469 | 0.0001 | |
| GSE63941 | GSDMB | 55876 | 219233_s_at | 1.1818 | 0.0388 | |
| GSE77861 | GSDMB | 55876 | 219233_s_at | 0.4699 | 0.1053 | |
| GSE97050 | GSDMB | 55876 | A_33_P3221999 | 0.3778 | 0.2876 | |
| SRP007169 | GSDMB | 55876 | RNAseq | 1.0592 | 0.1657 | |
| SRP064894 | GSDMB | 55876 | RNAseq | 1.0385 | 0.0000 | |
| SRP133303 | GSDMB | 55876 | RNAseq | 0.7035 | 0.0058 | |
| SRP159526 | GSDMB | 55876 | RNAseq | 1.4197 | 0.0108 | |
| SRP193095 | GSDMB | 55876 | RNAseq | -0.4096 | 0.3267 | |
| SRP219564 | GSDMB | 55876 | RNAseq | 0.7230 | 0.0898 | |
| TCGA | GSDMB | 55876 | RNAseq | -0.3448 | 0.0583 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by GSDMB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GSDMB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GSDMB | 55876 | 9 | 1 | 20 | |
| GSE20123 | GSDMB | 55876 | 9 | 1 | 20 | |
| GSE43470 | GSDMB | 55876 | 1 | 2 | 40 | |
| GSE46452 | GSDMB | 55876 | 34 | 0 | 25 | |
| GSE47630 | GSDMB | 55876 | 8 | 1 | 31 | |
| GSE54993 | GSDMB | 55876 | 3 | 4 | 63 | |
| GSE54994 | GSDMB | 55876 | 9 | 5 | 39 | |
| GSE60625 | GSDMB | 55876 | 4 | 0 | 7 | |
| GSE74703 | GSDMB | 55876 | 1 | 1 | 34 | |
| GSE74704 | GSDMB | 55876 | 5 | 1 | 14 | |
| TCGA | GSDMB | 55876 | 23 | 8 | 65 |
Total number of gains: 106; Total number of losses: 24; Total Number of normals: 358.
Somatic mutations of GSDMB:
Generating mutation plots.
Highly correlated genes for GSDMB:
Showing top 20/441 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GSDMB | KMT2B | 0.84423 | 3 | 0 | 3 |
| GSDMB | DUSP23 | 0.763011 | 3 | 0 | 3 |
| GSDMB | TAF4B | 0.750463 | 3 | 0 | 3 |
| GSDMB | RICTOR | 0.733874 | 3 | 0 | 3 |
| GSDMB | PPP4R4 | 0.715128 | 3 | 0 | 3 |
| GSDMB | ARF1 | 0.702297 | 4 | 0 | 3 |
| GSDMB | UCKL1 | 0.701744 | 3 | 0 | 3 |
| GSDMB | PGAP1 | 0.695053 | 4 | 0 | 3 |
| GSDMB | INPP4A | 0.692314 | 3 | 0 | 3 |
| GSDMB | TFAP2A | 0.691854 | 3 | 0 | 3 |
| GSDMB | WDR81 | 0.690579 | 5 | 0 | 5 |
| GSDMB | FASTKD3 | 0.689686 | 3 | 0 | 3 |
| GSDMB | CDCA7 | 0.687488 | 4 | 0 | 4 |
| GSDMB | MIA3 | 0.683852 | 5 | 0 | 5 |
| GSDMB | CHML | 0.681036 | 3 | 0 | 3 |
| GSDMB | RBM12B | 0.670787 | 4 | 0 | 3 |
| GSDMB | TRAPPC1 | 0.668436 | 3 | 0 | 3 |
| GSDMB | SAMD4B | 0.667943 | 3 | 0 | 3 |
| GSDMB | ACACA | 0.665947 | 4 | 0 | 4 |
| GSDMB | RNASEH2B | 0.664641 | 3 | 0 | 3 |
For details and further investigation, click here
