| Full name: SH2B adaptor protein 2 | Alias Symbol: APS | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 10603 | HGNC ID: HGNC:17381 | Ensembl Gene: ENSG00000160999 | OMIM ID: 605300 |
| Drug and gene relationship at DGIdb | |||
SH2B2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04722 | Neurotrophin signaling pathway | |
| hsa04910 | Insulin signaling pathway |
Expression of SH2B2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH2B2 | 10603 | 205367_at | 0.6241 | 0.2180 | |
| GSE20347 | SH2B2 | 10603 | 205367_at | 0.7421 | 0.0001 | |
| GSE23400 | SH2B2 | 10603 | 205367_at | 0.3290 | 0.0000 | |
| GSE26886 | SH2B2 | 10603 | 205367_at | 0.9893 | 0.0000 | |
| GSE29001 | SH2B2 | 10603 | 205367_at | 0.5114 | 0.0500 | |
| GSE38129 | SH2B2 | 10603 | 205367_at | 0.4304 | 0.0170 | |
| GSE45670 | SH2B2 | 10603 | 205367_at | 0.2819 | 0.0198 | |
| GSE63941 | SH2B2 | 10603 | 205367_at | 0.5942 | 0.0271 | |
| GSE77861 | SH2B2 | 10603 | 205367_at | 0.4504 | 0.0325 | |
| GSE97050 | SH2B2 | 10603 | A_33_P3414389 | 0.6003 | 0.1506 | |
| SRP064894 | SH2B2 | 10603 | RNAseq | 1.0546 | 0.0018 | |
| SRP133303 | SH2B2 | 10603 | RNAseq | 0.6067 | 0.0170 | |
| SRP159526 | SH2B2 | 10603 | RNAseq | 0.3224 | 0.4366 | |
| SRP193095 | SH2B2 | 10603 | RNAseq | 0.8837 | 0.0003 | |
| SRP219564 | SH2B2 | 10603 | RNAseq | 1.0400 | 0.1252 | |
| TCGA | SH2B2 | 10603 | RNAseq | 0.3860 | 0.0043 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SH2B2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SH2B2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH2B2 | 10603 | 13 | 0 | 17 | |
| GSE20123 | SH2B2 | 10603 | 13 | 0 | 17 | |
| GSE43470 | SH2B2 | 10603 | 6 | 2 | 35 | |
| GSE46452 | SH2B2 | 10603 | 10 | 1 | 48 | |
| GSE47630 | SH2B2 | 10603 | 7 | 3 | 30 | |
| GSE54993 | SH2B2 | 10603 | 1 | 10 | 59 | |
| GSE54994 | SH2B2 | 10603 | 15 | 4 | 34 | |
| GSE60625 | SH2B2 | 10603 | 0 | 0 | 11 | |
| GSE74703 | SH2B2 | 10603 | 6 | 1 | 29 | |
| GSE74704 | SH2B2 | 10603 | 10 | 0 | 10 | |
| TCGA | SH2B2 | 10603 | 53 | 6 | 37 |
Total number of gains: 134; Total number of losses: 27; Total Number of normals: 327.
Somatic mutations of SH2B2:
Generating mutation plots.
Highly correlated genes for SH2B2:
Showing top 20/1062 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH2B2 | UTP23 | 0.815082 | 3 | 0 | 3 |
| SH2B2 | USP34 | 0.808339 | 5 | 0 | 5 |
| SH2B2 | DDX59 | 0.805213 | 5 | 0 | 5 |
| SH2B2 | GNB5 | 0.795877 | 3 | 0 | 3 |
| SH2B2 | TIMM8A | 0.784103 | 3 | 0 | 3 |
| SH2B2 | ZNF721 | 0.779155 | 9 | 0 | 9 |
| SH2B2 | CCDC127 | 0.77833 | 3 | 0 | 3 |
| SH2B2 | GTSE1 | 0.772268 | 9 | 0 | 9 |
| SH2B2 | LTBR | 0.766161 | 3 | 0 | 3 |
| SH2B2 | SLC43A2 | 0.764793 | 3 | 0 | 3 |
| SH2B2 | MZT2B | 0.764223 | 9 | 0 | 9 |
| SH2B2 | IFT140 | 0.762476 | 3 | 0 | 3 |
| SH2B2 | KLHL24 | 0.760346 | 8 | 0 | 8 |
| SH2B2 | PRR11 | 0.753878 | 9 | 0 | 9 |
| SH2B2 | FBXW12 | 0.752694 | 8 | 0 | 8 |
| SH2B2 | FJX1 | 0.738709 | 3 | 0 | 3 |
| SH2B2 | ZNF358 | 0.738618 | 3 | 0 | 3 |
| SH2B2 | ALS2 | 0.737859 | 3 | 0 | 3 |
| SH2B2 | QSOX2 | 0.735696 | 5 | 0 | 4 |
| SH2B2 | CMBL | 0.730622 | 4 | 0 | 4 |
For details and further investigation, click here
