| Full name: PR/SET domain 4 | Alias Symbol: PFM1 | ||
| Type: protein-coding gene | Cytoband: 12q23.3 | ||
| Entrez ID: 11108 | HGNC ID: HGNC:9348 | Ensembl Gene: ENSG00000110851 | OMIM ID: 605780 |
| Drug and gene relationship at DGIdb | |||
PRDM4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04722 | Neurotrophin signaling pathway |
Expression of PRDM4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRDM4 | 11108 | 218329_at | -0.0518 | 0.8012 | |
| GSE20347 | PRDM4 | 11108 | 218329_at | -0.4808 | 0.0001 | |
| GSE23400 | PRDM4 | 11108 | 218329_at | -0.3201 | 0.0000 | |
| GSE26886 | PRDM4 | 11108 | 218329_at | -0.5169 | 0.0444 | |
| GSE29001 | PRDM4 | 11108 | 218329_at | -0.3549 | 0.0809 | |
| GSE38129 | PRDM4 | 11108 | 218329_at | -0.2867 | 0.0150 | |
| GSE45670 | PRDM4 | 11108 | 218329_at | -0.0516 | 0.7647 | |
| GSE53622 | PRDM4 | 11108 | 92417 | -0.3429 | 0.0000 | |
| GSE53624 | PRDM4 | 11108 | 36858 | -0.4622 | 0.0000 | |
| GSE63941 | PRDM4 | 11108 | 218329_at | -0.8809 | 0.0057 | |
| GSE77861 | PRDM4 | 11108 | 218329_at | -0.1827 | 0.2965 | |
| GSE97050 | PRDM4 | 11108 | A_23_P117146 | -0.2117 | 0.4193 | |
| SRP007169 | PRDM4 | 11108 | RNAseq | -1.3895 | 0.0002 | |
| SRP008496 | PRDM4 | 11108 | RNAseq | -1.4481 | 0.0000 | |
| SRP064894 | PRDM4 | 11108 | RNAseq | -0.6608 | 0.0000 | |
| SRP133303 | PRDM4 | 11108 | RNAseq | -0.2308 | 0.2239 | |
| SRP159526 | PRDM4 | 11108 | RNAseq | -0.6061 | 0.0006 | |
| SRP193095 | PRDM4 | 11108 | RNAseq | -0.7594 | 0.0000 | |
| SRP219564 | PRDM4 | 11108 | RNAseq | -0.8033 | 0.0477 | |
| TCGA | PRDM4 | 11108 | RNAseq | -0.0518 | 0.2828 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PRDM4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRDM4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRDM4 | 11108 | 5 | 3 | 22 | |
| GSE20123 | PRDM4 | 11108 | 5 | 3 | 22 | |
| GSE43470 | PRDM4 | 11108 | 2 | 1 | 40 | |
| GSE46452 | PRDM4 | 11108 | 9 | 1 | 49 | |
| GSE47630 | PRDM4 | 11108 | 9 | 1 | 30 | |
| GSE54993 | PRDM4 | 11108 | 0 | 5 | 65 | |
| GSE54994 | PRDM4 | 11108 | 4 | 2 | 47 | |
| GSE60625 | PRDM4 | 11108 | 0 | 0 | 11 | |
| GSE74703 | PRDM4 | 11108 | 2 | 0 | 34 | |
| GSE74704 | PRDM4 | 11108 | 2 | 2 | 16 | |
| TCGA | PRDM4 | 11108 | 21 | 10 | 65 |
Total number of gains: 59; Total number of losses: 28; Total Number of normals: 401.
Somatic mutations of PRDM4:
Generating mutation plots.
Highly correlated genes for PRDM4:
Showing top 20/927 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRDM4 | SWAP70 | 0.765543 | 3 | 0 | 3 |
| PRDM4 | ZNF416 | 0.756025 | 5 | 0 | 5 |
| PRDM4 | CYB5R1 | 0.754337 | 3 | 0 | 3 |
| PRDM4 | GPBP1 | 0.752453 | 3 | 0 | 3 |
| PRDM4 | SETD4 | 0.748195 | 3 | 0 | 3 |
| PRDM4 | ZNF518A | 0.727198 | 3 | 0 | 3 |
| PRDM4 | ZNF92 | 0.719115 | 3 | 0 | 3 |
| PRDM4 | FUT11 | 0.71113 | 3 | 0 | 3 |
| PRDM4 | KDM3A | 0.708316 | 3 | 0 | 3 |
| PRDM4 | EVI5 | 0.707798 | 3 | 0 | 3 |
| PRDM4 | GBF1 | 0.707183 | 3 | 0 | 3 |
| PRDM4 | LYSMD3 | 0.688058 | 4 | 0 | 4 |
| PRDM4 | ZNF382 | 0.683086 | 3 | 0 | 3 |
| PRDM4 | ZFP82 | 0.682941 | 3 | 0 | 3 |
| PRDM4 | ARHGEF6 | 0.678855 | 3 | 0 | 3 |
| PRDM4 | KPNA3 | 0.678406 | 4 | 0 | 4 |
| PRDM4 | ZMYM2 | 0.676881 | 4 | 0 | 3 |
| PRDM4 | RAB18 | 0.675918 | 4 | 0 | 3 |
| PRDM4 | CCNYL1 | 0.67176 | 5 | 0 | 5 |
| PRDM4 | TRERF1 | 0.669454 | 4 | 0 | 3 |
For details and further investigation, click here
