| Full name: RAB18, member RAS oncogene family | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10p12.1 | ||
| Entrez ID: 22931 | HGNC ID: HGNC:14244 | Ensembl Gene: ENSG00000099246 | OMIM ID: 602207 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RAB18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAB18 | 22931 | 223336_s_at | -0.3423 | 0.3815 | |
| GSE26886 | RAB18 | 22931 | 224377_s_at | -0.6386 | 0.0047 | |
| GSE45670 | RAB18 | 22931 | 223336_s_at | -0.0400 | 0.7943 | |
| GSE53622 | RAB18 | 22931 | 9430 | -0.4842 | 0.0000 | |
| GSE53624 | RAB18 | 22931 | 9430 | -0.4723 | 0.0000 | |
| GSE63941 | RAB18 | 22931 | 224787_s_at | -0.2617 | 0.6070 | |
| GSE77861 | RAB18 | 22931 | 224377_s_at | -0.4376 | 0.1393 | |
| GSE97050 | RAB18 | 22931 | A_33_P3299754 | -0.0176 | 0.9597 | |
| SRP007169 | RAB18 | 22931 | RNAseq | -1.3107 | 0.0008 | |
| SRP008496 | RAB18 | 22931 | RNAseq | -0.8032 | 0.0006 | |
| SRP064894 | RAB18 | 22931 | RNAseq | -0.5382 | 0.0128 | |
| SRP133303 | RAB18 | 22931 | RNAseq | -0.2334 | 0.2888 | |
| SRP159526 | RAB18 | 22931 | RNAseq | -0.6038 | 0.1678 | |
| SRP193095 | RAB18 | 22931 | RNAseq | -0.6267 | 0.0001 | |
| SRP219564 | RAB18 | 22931 | RNAseq | -0.7560 | 0.0120 | |
| TCGA | RAB18 | 22931 | RNAseq | 0.0335 | 0.5489 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RAB18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAB18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAB18 | 22931 | 6 | 7 | 17 | |
| GSE20123 | RAB18 | 22931 | 6 | 6 | 18 | |
| GSE43470 | RAB18 | 22931 | 3 | 4 | 36 | |
| GSE46452 | RAB18 | 22931 | 1 | 14 | 44 | |
| GSE47630 | RAB18 | 22931 | 5 | 15 | 20 | |
| GSE54993 | RAB18 | 22931 | 9 | 0 | 61 | |
| GSE54994 | RAB18 | 22931 | 3 | 9 | 41 | |
| GSE60625 | RAB18 | 22931 | 0 | 0 | 11 | |
| GSE74703 | RAB18 | 22931 | 2 | 2 | 32 | |
| GSE74704 | RAB18 | 22931 | 1 | 5 | 14 | |
| TCGA | RAB18 | 22931 | 19 | 23 | 54 |
Total number of gains: 55; Total number of losses: 85; Total Number of normals: 348.
Somatic mutations of RAB18:
Generating mutation plots.
Highly correlated genes for RAB18:
Showing top 20/730 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAB18 | CD59 | 0.840827 | 3 | 0 | 3 |
| RAB18 | COMMD10 | 0.818581 | 3 | 0 | 3 |
| RAB18 | ZCCHC9 | 0.814839 | 4 | 0 | 4 |
| RAB18 | TMEM167A | 0.802123 | 3 | 0 | 3 |
| RAB18 | RNF111 | 0.800613 | 3 | 0 | 3 |
| RAB18 | MAGT1 | 0.780252 | 3 | 0 | 3 |
| RAB18 | IBTK | 0.780214 | 3 | 0 | 3 |
| RAB18 | TRAPPC6B | 0.779534 | 3 | 0 | 3 |
| RAB18 | EPG5 | 0.776479 | 3 | 0 | 3 |
| RAB18 | CCNH | 0.771282 | 3 | 0 | 3 |
| RAB18 | TPRKB | 0.756788 | 3 | 0 | 3 |
| RAB18 | DRAM2 | 0.753279 | 4 | 0 | 4 |
| RAB18 | PALMD | 0.740659 | 4 | 0 | 4 |
| RAB18 | CRBN | 0.73238 | 3 | 0 | 3 |
| RAB18 | PPIP5K2 | 0.728338 | 3 | 0 | 3 |
| RAB18 | IL1R2 | 0.728166 | 3 | 0 | 3 |
| RAB18 | STOML2 | 0.727431 | 3 | 0 | 3 |
| RAB18 | RPAP2 | 0.726412 | 3 | 0 | 3 |
| RAB18 | ALG13 | 0.725241 | 3 | 0 | 3 |
| RAB18 | C1orf56 | 0.722546 | 3 | 0 | 3 |
For details and further investigation, click here
