| Full name: karyopherin subunit alpha 3 | Alias Symbol: SRP1gamma|SRP4|hSRP1|IPOA4 | ||
| Type: protein-coding gene | Cytoband: 13q14.2 | ||
| Entrez ID: 3839 | HGNC ID: HGNC:6396 | Ensembl Gene: ENSG00000102753 | OMIM ID: 601892 |
| Drug and gene relationship at DGIdb | |||
Expression of KPNA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KPNA3 | 3839 | 221502_at | -0.1652 | 0.5526 | |
| GSE20347 | KPNA3 | 3839 | 221502_at | -0.3845 | 0.0205 | |
| GSE23400 | KPNA3 | 3839 | 221502_at | -0.0614 | 0.4224 | |
| GSE26886 | KPNA3 | 3839 | 221502_at | -0.9176 | 0.0001 | |
| GSE29001 | KPNA3 | 3839 | 221502_at | -0.1055 | 0.7467 | |
| GSE38129 | KPNA3 | 3839 | 221502_at | -0.3063 | 0.0163 | |
| GSE45670 | KPNA3 | 3839 | 221502_at | -0.0317 | 0.8306 | |
| GSE53622 | KPNA3 | 3839 | 80696 | -0.3551 | 0.0000 | |
| GSE53624 | KPNA3 | 3839 | 80696 | -0.2047 | 0.0001 | |
| GSE63941 | KPNA3 | 3839 | 221502_at | -1.0415 | 0.0108 | |
| GSE77861 | KPNA3 | 3839 | 221502_at | 0.0680 | 0.8277 | |
| GSE97050 | KPNA3 | 3839 | A_33_P3214884 | -0.4464 | 0.1682 | |
| SRP007169 | KPNA3 | 3839 | RNAseq | -0.1435 | 0.6883 | |
| SRP008496 | KPNA3 | 3839 | RNAseq | -0.2350 | 0.3401 | |
| SRP064894 | KPNA3 | 3839 | RNAseq | -0.0755 | 0.6600 | |
| SRP133303 | KPNA3 | 3839 | RNAseq | 0.0921 | 0.5137 | |
| SRP159526 | KPNA3 | 3839 | RNAseq | -0.5622 | 0.0462 | |
| SRP193095 | KPNA3 | 3839 | RNAseq | -0.1669 | 0.1883 | |
| SRP219564 | KPNA3 | 3839 | RNAseq | -0.5545 | 0.0821 | |
| TCGA | KPNA3 | 3839 | RNAseq | 0.0116 | 0.7984 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KPNA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KPNA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KPNA3 | 3839 | 1 | 13 | 16 | |
| GSE20123 | KPNA3 | 3839 | 1 | 12 | 17 | |
| GSE43470 | KPNA3 | 3839 | 3 | 13 | 27 | |
| GSE46452 | KPNA3 | 3839 | 0 | 32 | 27 | |
| GSE47630 | KPNA3 | 3839 | 2 | 27 | 11 | |
| GSE54993 | KPNA3 | 3839 | 12 | 2 | 56 | |
| GSE54994 | KPNA3 | 3839 | 2 | 14 | 37 | |
| GSE60625 | KPNA3 | 3839 | 0 | 3 | 8 | |
| GSE74703 | KPNA3 | 3839 | 3 | 10 | 23 | |
| GSE74704 | KPNA3 | 3839 | 0 | 9 | 11 | |
| TCGA | KPNA3 | 3839 | 9 | 37 | 50 |
Total number of gains: 33; Total number of losses: 172; Total Number of normals: 283.
Somatic mutations of KPNA3:
Generating mutation plots.
Highly correlated genes for KPNA3:
Showing top 20/697 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KPNA3 | ARL6 | 0.77583 | 3 | 0 | 3 |
| KPNA3 | UIMC1 | 0.759216 | 3 | 0 | 3 |
| KPNA3 | XKR4 | 0.743486 | 3 | 0 | 3 |
| KPNA3 | RHBDD1 | 0.742285 | 3 | 0 | 3 |
| KPNA3 | BTD | 0.740381 | 4 | 0 | 3 |
| KPNA3 | ZYG11B | 0.730793 | 4 | 0 | 4 |
| KPNA3 | IRAK4 | 0.726969 | 3 | 0 | 3 |
| KPNA3 | RWDD4 | 0.726203 | 4 | 0 | 4 |
| KPNA3 | RPL37A | 0.724771 | 3 | 0 | 3 |
| KPNA3 | CLIP3 | 0.717991 | 4 | 0 | 4 |
| KPNA3 | EPC2 | 0.717507 | 3 | 0 | 3 |
| KPNA3 | SYTL4 | 0.715605 | 3 | 0 | 3 |
| KPNA3 | EPM2AIP1 | 0.710996 | 4 | 0 | 3 |
| KPNA3 | FIBIN | 0.710588 | 3 | 0 | 3 |
| KPNA3 | NKTR | 0.706263 | 3 | 0 | 3 |
| KPNA3 | AZIN1 | 0.70486 | 4 | 0 | 4 |
| KPNA3 | SELENBP1 | 0.704595 | 4 | 0 | 3 |
| KPNA3 | ASB5 | 0.704474 | 4 | 0 | 4 |
| KPNA3 | BVES | 0.703228 | 4 | 0 | 4 |
| KPNA3 | MOXD1 | 0.702162 | 3 | 0 | 3 |
For details and further investigation, click here
