ZMYM2

 

Full name: zinc finger MYM-type containing 2 Alias Symbol: RAMP|FIM|MYM
Type: protein-coding gene Cytoband: 13q12.11
Entrez ID: 7750 HGNC ID: HGNC:12989 Ensembl Gene: ENSG00000121741 OMIM ID: 602221
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ZMYM2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZMYM2 7750 202778_s_at -0.1163 0.8253
GSE20347 ZMYM2 7750 202778_s_at -0.3485 0.0422
GSE23400 ZMYM2 7750 202778_s_at -0.0759 0.4998
GSE26886 ZMYM2 7750 202778_s_at -0.0409 0.9060
GSE29001 ZMYM2 7750 202778_s_at -0.2093 0.2368
GSE38129 ZMYM2 7750 202778_s_at -0.1189 0.4803
GSE45670 ZMYM2 7750 202778_s_at -0.2052 0.1351
GSE53622 ZMYM2 7750 23859 0.1358 0.0422
GSE53624 ZMYM2 7750 23859 -0.1709 0.0074
GSE63941 ZMYM2 7750 202778_s_at -0.2242 0.7559
GSE77861 ZMYM2 7750 202778_s_at -0.3065 0.2302
GSE97050 ZMYM2 7750 A_23_P99405 -0.0846 0.6594
SRP007169 ZMYM2 7750 RNAseq -0.6526 0.0520
SRP008496 ZMYM2 7750 RNAseq -0.5154 0.0022
SRP064894 ZMYM2 7750 RNAseq -0.4542 0.0908
SRP133303 ZMYM2 7750 RNAseq -0.0970 0.5500
SRP159526 ZMYM2 7750 RNAseq -0.8339 0.0000
SRP193095 ZMYM2 7750 RNAseq -0.4238 0.0000
SRP219564 ZMYM2 7750 RNAseq -0.8119 0.0287
TCGA ZMYM2 7750 RNAseq -0.0898 0.0691

Upregulated datasets: 0; Downregulated datasets: 0.  


 

Survival by ZMYM2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of ZMYM2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZMYM2 7750 1 16 13
GSE20123 ZMYM2 7750 1 15 14
GSE43470 ZMYM2 7750 1 13 29
GSE46452 ZMYM2 7750 0 33 26
GSE47630 ZMYM2 7750 3 26 11
GSE54993 ZMYM2 7750 11 2 57
GSE54994 ZMYM2 7750 1 13 39
GSE60625 ZMYM2 7750 0 3 8
GSE74703 ZMYM2 7750 1 10 25
GSE74704 ZMYM2 7750 0 13 7
TCGA ZMYM2 7750 7 43 46

Total number of gains: 26; Total number of losses: 187; Total Number of normals: 275.  


 

Somatic mutations of ZMYM2:

 

Generating mutation plots.

 

Highly correlated genes for ZMYM2:

 

Showing top 20/453 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZMYM2TTC39B0.801207303
ZMYM2USP320.793776303
ZMYM2CRLF30.771048404
ZMYM2CST60.770533303
ZMYM2C9orf850.765394303
ZMYM2ITCH0.748894404
ZMYM2VCPIP10.737663303
ZMYM2TNIP10.736678303
ZMYM2FAM174A0.732395303
ZMYM2ATG4A0.727345404
ZMYM2IPMK0.722998403
ZMYM2ELK30.721943404
ZMYM2SPTY2D10.717939303
ZMYM2FBXL30.716864404
ZMYM2WDFY20.713562404
ZMYM2UCHL50.713225404
ZMYM2PLEKHA70.696293303
ZMYM2ERP440.694535303
ZMYM2ZFP300.693393303
ZMYM2SLC22A150.692588303

For details and further investigation, click here