| Full name: prolyl endopeptidase like | Alias Symbol: KIAA0436 | ||
| Type: protein-coding gene | Cytoband: 2p21 | ||
| Entrez ID: 9581 | HGNC ID: HGNC:30228 | Ensembl Gene: ENSG00000138078 | OMIM ID: 609557 |
| Drug and gene relationship at DGIdb | |||
Expression of PREPL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PREPL | 9581 | 212215_at | -0.0596 | 0.9106 | |
| GSE20347 | PREPL | 9581 | 212215_at | 0.0823 | 0.6693 | |
| GSE23400 | PREPL | 9581 | 212215_at | -0.0644 | 0.5498 | |
| GSE26886 | PREPL | 9581 | 212215_at | -0.6336 | 0.0036 | |
| GSE29001 | PREPL | 9581 | 212215_at | 0.2622 | 0.1321 | |
| GSE38129 | PREPL | 9581 | 212215_at | -0.2020 | 0.2269 | |
| GSE45670 | PREPL | 9581 | 212215_at | -0.4903 | 0.0066 | |
| GSE53622 | PREPL | 9581 | 10719 | -0.4255 | 0.0000 | |
| GSE53624 | PREPL | 9581 | 10719 | -0.2185 | 0.0053 | |
| GSE63941 | PREPL | 9581 | 212215_at | -0.8747 | 0.1194 | |
| GSE77861 | PREPL | 9581 | 212215_at | -0.1716 | 0.5533 | |
| GSE97050 | PREPL | 9581 | A_24_P943193 | -0.9458 | 0.1057 | |
| SRP007169 | PREPL | 9581 | RNAseq | 0.3086 | 0.3983 | |
| SRP008496 | PREPL | 9581 | RNAseq | 0.4383 | 0.0313 | |
| SRP064894 | PREPL | 9581 | RNAseq | -0.3256 | 0.0796 | |
| SRP133303 | PREPL | 9581 | RNAseq | -0.1525 | 0.3081 | |
| SRP159526 | PREPL | 9581 | RNAseq | 0.2871 | 0.1016 | |
| SRP193095 | PREPL | 9581 | RNAseq | -0.1551 | 0.1051 | |
| SRP219564 | PREPL | 9581 | RNAseq | 0.0295 | 0.9193 | |
| TCGA | PREPL | 9581 | RNAseq | -0.1923 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PREPL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PREPL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PREPL | 9581 | 10 | 1 | 19 | |
| GSE20123 | PREPL | 9581 | 9 | 1 | 20 | |
| GSE43470 | PREPL | 9581 | 4 | 0 | 39 | |
| GSE46452 | PREPL | 9581 | 1 | 4 | 54 | |
| GSE47630 | PREPL | 9581 | 7 | 0 | 33 | |
| GSE54993 | PREPL | 9581 | 0 | 5 | 65 | |
| GSE54994 | PREPL | 9581 | 10 | 0 | 43 | |
| GSE60625 | PREPL | 9581 | 0 | 3 | 8 | |
| GSE74703 | PREPL | 9581 | 4 | 0 | 32 | |
| GSE74704 | PREPL | 9581 | 9 | 1 | 10 | |
| TCGA | PREPL | 9581 | 35 | 3 | 58 |
Total number of gains: 89; Total number of losses: 18; Total Number of normals: 381.
Somatic mutations of PREPL:
Generating mutation plots.
Highly correlated genes for PREPL:
Showing top 20/620 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PREPL | KIF13B | 0.776198 | 3 | 0 | 3 |
| PREPL | ZNF514 | 0.750978 | 3 | 0 | 3 |
| PREPL | ZNF564 | 0.742278 | 3 | 0 | 3 |
| PREPL | ZBTB26 | 0.728916 | 3 | 0 | 3 |
| PREPL | NEK3 | 0.727411 | 3 | 0 | 3 |
| PREPL | C1QTNF7 | 0.710366 | 4 | 0 | 4 |
| PREPL | DCTN4 | 0.709437 | 3 | 0 | 3 |
| PREPL | ATP9B | 0.708845 | 3 | 0 | 3 |
| PREPL | SLC2A12 | 0.701861 | 3 | 0 | 3 |
| PREPL | SCOC | 0.699894 | 4 | 0 | 3 |
| PREPL | SALL2 | 0.698364 | 3 | 0 | 3 |
| PREPL | BTD | 0.696319 | 4 | 0 | 4 |
| PREPL | DSEL | 0.686165 | 3 | 0 | 3 |
| PREPL | METTL14 | 0.684895 | 4 | 0 | 3 |
| PREPL | HCFC2 | 0.681349 | 3 | 0 | 3 |
| PREPL | SLC35E2B | 0.678253 | 3 | 0 | 3 |
| PREPL | GUF1 | 0.675223 | 3 | 0 | 3 |
| PREPL | PCMTD1 | 0.672267 | 6 | 0 | 6 |
| PREPL | TMEM143 | 0.671041 | 3 | 0 | 3 |
| PREPL | FAM122A | 0.670367 | 4 | 0 | 3 |
For details and further investigation, click here
